DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and gabra1

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_009293960.1	Gene:	gabra1 / 768183	ZFINID:	ZDB-GENE-061013-194	Length:	470	Species:	Danio rerio

Alignment Length:	534	Identity:	184/534 - (34%)
Similarity:	271/534 - (50%)	Gaps:	116/534 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 SNQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDY 154
            |:|....:|....:.:|    ||::||..|:....|..|:.| |.|:|:|.:.|:||||:.||:|
Zfish    39 SSQNADEQKDNTTVFTR----ILDSLLDGYDNRLRPGLGERV-TEVKTDIFVTSIGPVSDHDMEY 98

  Fly   155 SMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNG 219
            ::|.:|||.|:|:||.||||:..|.|:..|..|||.|||:|:|||.|..|.:|:||||||:.:.|
Zfish    99 TIDVFFRQSWKDERLKFKGPMAVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEEG 163

  Fly   220 GILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFV---PGMTLN 281
            .:||:||||::|.|||.|::||||..:|||..|||.|...:::|.| .:..|.|.|   .|..||
Zfish   164 TLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYVW-TRGAAQSVVVADDGSRLN 227

  Fly   282 QFDLISMMHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSD 346
            |:||:.....:.......|::.|:...|:|||..|||:||.|:|||:.|:||.||||::||:...
Zfish   228 QYDLMGQSVDSGVVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPA 292

  Fly   347 RVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESP 411
            |....||:|||::|:|:.:|..||||.||||:|||:.:.:.:..:.|:|||.|:||||.|..
Zfish   293 RTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYA--- 354

  Fly   412 QLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCN 476
                 |:                                          |.|...|.:.     .
Zfish   355 -----WD------------------------------------------GKSVVPEKQK-----K 367

  Fly   477 KNDALGLEYEVSLQNSLAGAGFLKRN--------AIFCPTY-NDPSYILPNTMERTTQTEPPAVS 532
            |.::|                 ||:|        ..|.|.. .||.      :....::.||..:
Zfish   368 KKESL-----------------LKKNNTYTAATATAFAPNIARDPG------LATIAKSAPPPPT 409

  Fly   533 RLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWA 597
            ...:            :.:.:...|:|:        .||||.|||:||||||:.|...||:||..
Zfish   410 EPKE------------EPKPKPPEAKKT--------FNSVSKIDRIARIAFPLLFGTFNLVYWAT 454

  Fly   598 YGMYKKEFSWSNMK 611
            |...|.:....|::
Zfish   455 YLNKKPKLQGMNLQ 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	180/517 (35%)
		Neur_chan_LBD	111..315	CDD:280998	94/206 (46%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
gabra1	XP_009293960.1	LIC	17..455	CDD:273305	181/519 (35%)
		Neur_chan_LBD	54..261	CDD:280998	95/212 (45%)
		Neur_chan_memb	268..452	CDD:280999	76/281 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3005
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2100
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3154
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	8.100