DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and Gabre

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_075579.1	Gene:	Gabre / 65191	RGDID:	68320	Length:	989	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	156/544 - (28%)
Similarity:	251/544 - (46%)	Gaps:	84/544 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PSSKPKTNGSLKRSQNATNLSYSSSEISNQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTH 127
            |..:.:....|:...:...|....:|::......|...  .|:| .|.||..:|..|:....|:.
  Rat   513 PELELEPQSQLEPQPSGKKLPARETELTADHTTERPRG--KLTR-ASQILNTILSNYDHKLRPSI 574

  Fly   128 GQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPD 192
            |: .||||...:.:.|:||:|.|||:||:|..|.|.|.|:||.:....::|.|...::.::|.||
  Rat   575 GE-KPTVVTVKVFVNSLGPISILDMEYSIDIIFYQTWYDERLRYNDTFETLILHGNVVSQLWIPD 638

  Fly   193 TYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYI 257
            |:|.|.|.:|.:.||:||::..:.::|.:||::|:||.|.|.:.:.|||||..||||...|:.|.
  Rat   639 TFFRNSKRTQEYDITIPNQMALIHKDGKVLYTVRMTIDARCSLHMLNFPMDSHSCPLSFSSFSYD 703

  Fly   258 NQQLIYEWKNQDDAVSFVPGMTLNQFDLISMMHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQV 322
            ..::||:|:|....:.......|.:||...:.::........|||.|:...||:.|..|:.:.|.
  Rat   704 EHEMIYKWENFKLKIDAKNTWKLLEFDFTGVNNKTEIISTPVGDFMVMTFFFNVSRRFGFIVFQN 768

  Fly   323 YVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFL 387
            |:|..:..:||||||||..||.:.|.|:.|:||||::|:...||.:.|:|.|.||||:::.:.|:
  Rat   769 YIPSSVTTMLSWVSFWIKIEAAAARASVGVSSVLTMATLGTFSRKNFPRVSYLTALDFYIAICFV 833

  Fly   388 YCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNG 452
            .|..|||||..:::.|                   .|::           |..|.|...:..:|.
  Rat   834 LCFCTLLEFTVLNFLT-------------------YNNI-----------ERQASPKFYQFPTNS 868

  Fly   453 SENDDNEAGASESVESKS------GVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYND 511
            ..|....|.|.....:::      .|.||..     :.||.:.:.....:...:|..  ||
  Rat   869 RANARTRARARTRARARARARQQQEVFVCEI-----VTYEENAEEGYQWSPRSRRPQ--CP---- 922

  Fly   512 PSYILPNTMERTTQTEPPAVSRLHQMW-MCLKSDNSFRKQRERNAAAQKSE----QGGANCYVNS 571
                                      | .|.:|...||..|:........|    |.|..|.  .
  Rat   923 --------------------------WRRCGRSYVCFRVLRKYFCMVPGCEGNSWQRGRICI--H 959

  Fly   572 VSLIDRVARIAFPMSFAFLNLLYW 595
            |..:|..:|:.||::|.|.|::||
  Rat   960 VYRLDNYSRVLFPITFFFFNVVYW 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	152/515 (30%)
		Neur_chan_LBD	111..315	CDD:280998	73/203 (36%)
		Neur_chan_memb	322..>403	CDD:280999	36/80 (45%)
Gabre	NP_075579.1	Neur_chan_LBD	555..760	CDD:280998	73/205 (36%)
		LIC	557..983	CDD:273305	146/495 (29%)
		Neur_chan_memb	769..983	CDD:280999	71/282 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020