DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8916 and gabra6b

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_002667403.3	Gene:	gabra6b / 559693	ZFINID:	ZDB-GENE-080815-1	Length:	444	Species:	Danio rerio

Alignment Length:	500	Identity:	181/500 - (36%)
Similarity:	255/500 - (51%)	Gaps:	104/500 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 NISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSF 171
            ||:.||:.||..|:....|..| |..|.|:|:|.:.|.||||:::|:|:||.:|||.|.|.||.|
Zfish    30 NITRILDRLLDGYDNRLRPGFG-GPVTEVKTDIFVTSFGPVSDVEMEYTMDVFFRQTWIDDRLKF 93

  Fly   172 KGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPME 236
            :|||:.|.|:..|:.|||.|||:|.|||.|..|.:|.||||.|:.|||.|||:|||||.|.|||.
Zfish    94 EGPIEILRLNNLMVSKIWTPDTFFRNGKRSISHNMTTPNKLFRIMQNGTILYTMRLTINAECPMR 158

  Fly   237 LQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVP--GMTLNQFDLISMMHRNFTTVRRE 299
            |.|||||..||||..|||.|...:::|.||........||  ..:|.|:|||.....:.......
Zfish   159 LINFPMDGHSCPLKFGSYAYPMSEIVYTWKKGPLFSVEVPQESSSLLQYDLIGQTVSSERLKSNT 223

  Fly   300 GDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLD 364
            |::.|:.|.|:|:|..|:||||.|:|||:.|:|:.|||||.:|:...|....:|:|||::|:|:.
Zfish   224 GEYIVMTVYFHLQRKMGFFLIQTYIPCIMTVILAQVSFWIDKESVPARTVFGITTVLTMTTLSIS 288

  Fly   365 SRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLSDH 429
            :|..||||.||||:|||:.:.|.:..:.|:|||.|:||:.|.:.:    |.:..:|..| :.:..
Zfish   289 ARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFSTLQANK----ELRRANIARA-AAAAA 348

  Fly   430 AGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLA 494
            |...||:|                                                   :.|.|.
Zfish   349 AARSDGEG---------------------------------------------------VLNPLD 362

  Fly   495 GAGFLKRNAIFCPTYNDPSYILPNTMERTTQTE---PPAVSRLHQMWMCLKSDNSFRKQRERNAA 556
            ..|.||:..              |::.:.:.|:   .|:.|..||
Zfish   363 PGGVLKKRM--------------NSLSQRSATDRFSRPSQSDFHQ-------------------- 393

  Fly   557 AQKSEQGG---ANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
                 ||.   ||..:...|:||:.:||.||:||...||:||..|
Zfish   394 -----QGSAVPANNMLIGTSIIDKYSRILFPLSFGAFNLVYWIVY 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	180/498 (36%)
		Neur_chan_LBD	111..315	CDD:280998	98/205 (48%)
		Neur_chan_memb	322..>403	CDD:280999	38/80 (48%)
gabra6b	XP_002667403.3	Neur_chan_LBD	32..239	CDD:280998	98/207 (47%)
		LIC	33..433	CDD:273305	178/495 (36%)
		Neur_chan_memb	246..430	CDD:280999	73/278 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3005
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20220
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2100
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm24219
orthoMCL	1	0.900	-	-		OOG6_105663
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3154
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900