Protein Alignment CG8916 and GABRQ

DIOPT Version :9

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_061028.3
• Gene: GABRQ / 55879
• HGNCID: 14454
• Length: 632
• Species: Homo sapiens
• Alignment Length: 678
• Identity: 162/678 - (23%)
• Similarity: 285/678 - (42%)
• Gaps: 163/678 - (24%)

  Fly    29 LLYIKTM-----GPSAILTKMPNITNEFSSRIFSSFRILPSSKPKTNGSLKRSQNATNLSYSSSE 88
            ||.|:|.     .||.|    |....||||.:           |:...:|...:|..|.:.
Human    13 LLLIRTWLAEGNYPSPI----PKFHFEFSSAV-----------PEVVLNLFNCKNCANEAV---- 58

  Fly    89 ISNQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMD 153
                               :..||:.:|.||:....|..| |.|..|:.:|.:.|:..:||::||
Human    59 -------------------VQKILDRVLSRYDVRLRPNFG-GAPVPVRISIYVTSIEQISEMNMD 103

  Fly   154 YSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQN 218
            |::..:|.|.|:|.||::.....:|:|..:|.:|:|.||.||.|.|.:.:|.:||.|::.:|..:
Human   104 YTITMFFHQTWKDSRLAYYETTLNLTLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPD 168

  Fly   219 GGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQF 283
            |.:.|.:|||..|.|.::|..||||:|:|.||:.||||..:.:|..|.:..:|:.....:.:.||
Human   169 GTVRYGIRLTTTAACSLDLHKFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQF 233

  Fly   284 DLISMMHRNFTTVRRE-----GDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREA 343
            ..:..     |...:|     |.:..|.:.|.::|....:|:|||.|.:|..:.||:|||::.::
Human   234 TFLGR-----TITSKEVYFYTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDS 293

  Fly   344 TSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHY-FTKLGS 407
            ::.||::.:||:|.|:||....|..||.:....|:|.::|:...:...:|||:..::| |...|.
Human   294 SAARVTIGLTSMLILTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGP 358

  Fly   408 GESPQ---------LEDQWEDICIANSLSDHAGEVDGDGEADAD------PFADEDS--SNGSEN 455
            ...|:         ...:::.:.:.| :.|....|: ||.:...      |.|..:|  |..|.:
Human   359 RRQPRRHRRPRRVIARYRYQQVVVGN-VQDGLINVE-DGVSSLPITPAQAPLASPESLGSLTSTS 421

  Fly   456 DDNEAGASESVE---SKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYN----DPS 513
            :..:...|||:.   |.||.......::|         :.|.......|:: :...:|    |.|
Human   422 EQAQLATSESLSPLTSLSGQAPLATGESL---------SDLPSTSEQARHS-YGVRFNGFQADDS 476

  Fly   514 YILPNTMERTTQTEPPAVSRLHQ--------------------------------MW-------- 538
             |:|..:....:.....|:..|:                                .|
Human   477 -IIPTEIRNRVEAHGHGVTHDHEDSNESLSSDERHGHGPSGKPMLHHGEKGVQEAGWDLDDNNDK 540

  Fly   539 -MCLKSDNSFR------------------KQRERNAAAQKSEQGGANCYVNS-----------VS 573
             .||.....|:                  ::::.::.::.|......|....           |.
Human   541 SDCLAIKEQFKCDTNSTWGLNDDELMAHGQEKDSSSESEDSCPPSPGCSFTEGFSFDLFNPDYVP 605

  Fly   574 LIDRVARIAFPMSFAFLNLLYWWAYGMY 601
            .:|:.:|..||::|...|::| |.|.||
Human   606 KVDKWSRFLFPLAFGLFNIVY-WVYHMY 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	143/605 (24%)
		Neur_chan_LBD	111..315	CDD:280998	70/208 (34%)
		Neur_chan_memb	322..>403	CDD:280999	27/81 (33%)
GABRQ	NP_061028.3	Neur_chan_LBD	60..>353	CDD:332142	99/298 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..458		11/56 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	491..523		2/31 (6%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810