Protein Alignment CG8916 and gabra4

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001017822.1
• Gene: gabra4 / 550520
• ZFINID: ZDB-GENE-050417-360
• Length: 557
• Species: Danio rerio
• Alignment Length: 540
• Identity: 194/540 - (35%)
• Similarity: 281/540 - (52%)
• Gaps: 56/540 - (10%)

  Fly    89 ISNQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMD 153
            ||.|.|...|    :...|.:.||:.||..|:....|..| |..|.|:|:|.:.|.||||:::|:
Zfish    33 ISGQIRKDEK----LYPENFTRILDRLLDGYDNRLRPGFG-GPVTEVKTDIYVTSFGPVSDVEME 92

  Fly   154 YSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQN 218
            |:||.:|||.|.|:||.::||::.|.|:..|:.|:|.|||:|.|||.|..|.:|.||:|.|:.:|
Zfish    93 YTMDVFFRQTWVDRRLRYEGPVEILRLNNLMVTKVWTPDTFFRNGKRSVAHNMTAPNRLFRIMKN 157

  Fly   219 GGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEW-KNQDDAVSFVP-GMTLN 281
            |.|||:|||||.|.|||.|.|||||..||||..|||.|...::||.| |....:|...| ..:|.
Zfish   158 GTILYTMRLTISAECPMRLVNFPMDGHSCPLKFGSYAYPKTEMIYTWTKGPQHSVEVPPESSSLV 222

  Fly   282 QFDLISMMHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSD 346
            |:|||.....:.|.....|::.|:.|.|:|||..|||:||.|:|||:.|:||.|||||::|:...
Zfish   223 QYDLIGQTVSSETVKSITGEYVVMTVYFHLKRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPA 287

  Fly   347 RVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFT-------- 403
            |....:|:|||::|:|:.:|..||||.||||:|||:.:.|.:..:.|:|||.|:|||
Zfish   288 RTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNAQAERAK 352

  Fly   404 ------------KLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFAD-------EDS 449
                        |..:|::...|:      :....||..|.:.....::..|.|:       |.|
Zfish   353 RKQAKAAAAASVKSSTGKNKDTEE------VLQQNSDTNGNLRKRVNSNIQPQAESKKTQRTEAS 411

  Fly   450 SNGSENDDNEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSY 514
            |....:.......|:|..:..|....:....|. ....|..|:.|.:....:.....|    ||
Zfish   412 SKSGASSSKPTLTSQSSSTSEGTSSFSSQSRLS-PSSASQSNAAASSSSASKTTPPAP----PS- 470

  Fly   515 ILPNTMERTTQ-TEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRV 578
             .|...::.:. |.|...:.||.: :..|.:|..:|:.:..........|||       |.||..
Zfish   471 -TPTVPDKPSPGTTPAGSAPLHHL-LGPKLENIKKKEAKAQPQPAAPATGGA-------SKIDEY 526

  Fly   579 ARIAFPMSFAFLNLLYWWAY 598
            |||.||:||...|::||..|
Zfish   527 ARILFPVSFGAFNMVYWVVY 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	191/535 (36%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	87/183 (48%)
		Cys-loop	233..247	CDD:349808	9/13 (69%)
gabra4	NP_001017822.1	LGIC_ECD_GABAAR_A4	57..255	CDD:349838	91/198 (46%)
		Cys-loop	172..186	CDD:349838	9/13 (69%)
		LGIC_TM_GABAAR_alpha	258..347	CDD:349854	45/88 (51%)
		TM1 helix	258..281	CDD:349854	15/22 (68%)
		Neur_chan_memb	263..543	CDD:460753	84/300 (28%)
		TM2 helix	285..309	CDD:349854	8/23 (35%)
		TM3 helix	317..343	CDD:349854	11/25 (44%)