Protein Alignment CG8916 and Grd

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 691
• Identity: 231/691 - (33%)
• Similarity: 311/691 - (45%)
• Gaps: 238/691 - (34%)

  Fly    63 PSSKP--------KTNGSLKR-SQNATNLSYS--SSEISNQRRVRRKAAADMLSRNISMILENLL 116
            |.|.|        |..|...| .:..|:||.|  ||.::....          ..|||.:|:|||
  Fly    63 PGSGPFSVSADSIKGRGDTHRLGEMGTSLSSSLPSSWLTQSNN----------HANISELLDNLL 117

  Fly   117 KRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLS 181
            :.|:.|..|..| |.|..::.:|::|||||:||:||.|||||||||.|.||||:|:|...:|:||
  Fly   118 RGYDNSIRPDFG-GPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFEGAQDTLALS 181

  Fly   182 IKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQS 246
            :.||.:||:|||||||||.|.:|.||.|||.:|:.|||.:|||.||||||.|||.|.:||||.|.
  Fly   182 VSMLARIWKPDTYFYNGKQSYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPMNLADFPMDIQK 246

  Fly   247 CPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDLISMMHRNFTTV----------RR--- 298
            |||..||:||....:||.|..:...|:....|.|:||||:.....|.|.:          ||
  Fly   247 CPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKAAAPRPQRRPFN 311

  Fly   299 ---------------------------------------------------------------EG 300
                                                                           ..
  Fly   312 NKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLSGTITLETNHPS 376

  Fly   301 DFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDS 365
            ::|:|.|.|:|:||.|.||||||.||.|:|||||||||::||||:|||||.:|:|||::.:.|::
  Fly   377 EYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITTVLTMTFLGLEA 441

  Fly   366 RTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLSDHA 430
            |||||||.|.||||:|:.:||.:..||:|:||.|||:||.||||...:.:
  Fly   442 RTDLPKVSYPTALDFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIE--------------- 491

  Fly   431 GEVDGD-GEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLA 494
             |:|.: ||::.:|...:...              |.|||.              |||
  Fly   492 -ELDSESGESETEPLTSDFRG--------------STESKI--------------YEV------- 520

  Fly   495 GAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPA------------VSRLHQMW-MCLKSDNS 546
                                 :|.:|...:...||.            .:|.|.:| |.|.....
  Fly   521 ---------------------IPLSMCAISMPPPPTRLGMLTSRNRRPRNRRHGLWSMKLLGLFD 564

  Fly   547 FRKQRE---------------------------RNAAAQKSEQ---------------------- 562
            :|::|:                           ..||||.:.|
  Fly   565 WRRRRKPPRADSDEDEDDEQTQLRANEAPTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEM 629

  Fly   563 -----GGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
                 |......||||.|||.:||.||:.|..:|:.||:.|
  Fly   630 EARRKGKRTPQYNSVSKIDRASRIVFPLLFILINVFYWYGY 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	218/649 (34%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	98/257 (38%)
		Cys-loop	233..247	CDD:349808	9/13 (69%)
Grd	NP_524131.1	LIC	111..670	CDD:455710	215/631 (34%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	91/167 (54%)
		Cys-loop	233..247	CDD:349808	9/13 (69%)