DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8916 and GLRB

DIOPT Version :9

Sequence 1:NP_573090.3 Gene:CG8916 / 32553 FlyBaseID:FBgn0030707 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_000815.1 Gene:GLRB / 2743 HGNCID:4329 Length:497 Species:Homo sapiens


Alignment Length:538 Identity:155/538 - (28%)
Similarity:252/538 - (46%) Gaps:83/538 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 SYSSSEISNQRRVRRK-------AAADMLSR----NISMILENLLKRYEQSQLPTHGQGVPTVVQ 136
            :||..:.|.:.:.::|       .:|:.|:|    :.|.||..||..|:....|.. :|:|..|.
Human    20 AYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNF-KGIPVDVV 83

  Fly   137 TNILIRSMGPVSELDMDYSMDCYFRQYWRDKRL----SFKGPIKSLSLSIKMLDKIWRPDTYFYN 197
            .||.|.|.|.:.|..|||.::.:.||.|.|.||    .|:|. .:|::...|...:|:||.:|.|
Human    84 VNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGS-DALTVDPTMYKCLWKPDLFFAN 147

  Fly   198 GKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLI 262
            .|.:..|.:|..|.||.:.::|.:|.||||:|..:||::|..||||.|.|.:.:.|:||....|.
Human   148 EKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLR 212

  Fly   263 YEWKNQDDAVSFVPGMTLNQFDL--ISMMHRNFTT-VRREGDFSVLHVAFNLKRHTGYFLIQVYV 324
            :.|::.|...  :..:.|.|||:  ..:.:.|.|. .:..|.::.:.|.|.|:|..|::::.||.
Human   213 FIWQSGDPVQ--LEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYA 275

  Fly   325 PCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYC 389
            |.:|||||||:||||:.:|::.||.|.:.|||:|::.......:||||.|..|||.:|:...|:.
Human   276 PTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFG 340

  Fly   390 IATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSE 454
            .|:|:|:|.|....     .:|:..:. |...||.     |.:.||.|    ...|.:::.||:.
Human   341 FASLVEYAVVQVML-----NNPKRVEA-EKARIAK-----AEQADGKG----GNVAKKNTVNGTG 390

  Fly   455 NDDNEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNT 519
            ...:.:...........||. :|:|....::      |:.|:                   ||..
Human   391 TPVHISTLQVGETRCKKVCT-SKSDLRSNDF------SIVGS-------------------LPRD 429

  Fly   520 MERTTQTEPPAVSRLHQMWMC----LKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVAR 580
            .|.:.             :.|    ::.:|...|.:.:|   .|...........:...||..||
Human   430 FELSN-------------YDCYGKPIEVNNGLGKSQAKN---NKKPPPAKPVIPTAAKRIDLYAR 478

  Fly   581 IAFPMSFAFLNLLYWWAY 598
            ..||..|.|.|::||..|
Human   479 ALFPFCFLFFNVIYWSIY 496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8916NP_573090.3 LIC 92..598 CDD:273305 151/527 (29%)
Neur_chan_LBD 111..315 CDD:280998 72/210 (34%)
Neur_chan_memb 322..>403 CDD:280999 37/80 (46%)
GLRBNP_000815.1 LIC 43..496 CDD:273305 150/513 (29%)
LGIC_ECD_GlyR_beta 79..265 CDD:349811 64/188 (34%)
Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430 247..253 1/5 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.770

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