Protein Alignment CG8916 and GLRA1

DIOPT Version :9

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001139512.1
• Gene: GLRA1 / 2741
• HGNCID: 4326
• Length: 457
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 165/537 - (30%)
• Similarity: 251/537 - (46%)
• Gaps: 117/537 - (21%)

  Fly    84 YSSSEISNQRRVRRKAAADMLSRNISMILENLLKR---YEQSQLPTHGQGVPTVVQTNILIRSMG 145
            :.|...|.:....|.|...|   :.|..|:.|:.|   |: :::..:.:|.|..|..||.|.|.|
Human    17 FFSLAASKEAEAARSAPKPM---SPSDFLDKLMGRTSGYD-ARIRPNFKGPPVNVSCNIFINSFG 77

  Fly   146 PVSELDMDYSMDCYFRQYWRDKRLSF-KGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVP 209
            .::|..|||.::.:.||.|.|.||:: :.|..||.|...|||.||:||.:|.|.|.:..|.||..
Human    78 SIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTD 142

  Fly   210 NKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSF 274
            |||||:.:||.:|||:|:|:...|||:|:|||||.|:|.:.:.|:||....||:||:.| .||..
Human   143 NKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQ-GAVQV 206

  Fly   275 VPGMTLNQFDLISMMHRNFTTVR-REGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFW 338
            ..|:||.||.|.......:.|.. ..|.|:.:...|:|:|..||:|||:|:|.:|||:|||:|||
Human   207 ADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFW 271

  Fly   339 IHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFT 403
            |:.:|...||.|.:|:|||::|.|..||..||||.|..|:|.::.:..|:..:.|||:|.|::.:
Human   272 INMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVS 336

  Fly   404 -----------KLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDD 457
                       |....:||.|                            :.|.::::..|..|..
Human   337 RQHKELLRFRRKRRHHKSPML----------------------------NLFQEDEAGEGRFNFS 373

  Fly   458 NEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMER 522
            ........:::|.|:.|...|::
Human   374 AYGMGPACLQAKDGISVKGANNS------------------------------------------ 396

  Fly   523 TTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSF 587
            .|...|||.|         ||....||                 .::.....||:::||.|||:|
Human   397 NTTNPPPAPS---------KSPEEMRK-----------------LFIQRAKKIDKISRIGFPMAF 435

  Fly   588 AFLNLLYWWAYGMYKKE 604
            ...|:.||..|.:.::|
Human   436 LIFNMFYWIIYKIVRRE 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	161/521 (31%)
		Neur_chan_LBD	111..315	CDD:280998	84/208 (40%)
		Neur_chan_memb	322..>403	CDD:280999	37/80 (46%)
GLRA1	NP_001139512.1	LIC	7..446	CDD:273305	163/529 (31%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	230..235		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..410		8/69 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810