Protein Alignment CG8916 and GABRR2

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_002034.3
• Gene: GABRR2 / 2570
• HGNCID: 4091
• Length: 465
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 160/538 - (29%)
• Similarity: 249/538 - (46%)
• Gaps: 120/538 - (22%)

  Fly    67 PKTNGSLKRSQNATNLSYSSSEISNQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGV 131
            ||.:...|::.:.|.:              ||.....|.|         :..::.|..|..| |.
Human    35 PKPSHLYKKNLDVTKI--------------RKGKPQQLLR---------VDEHDFSMRPAFG-GP 75

  Fly   132 PTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFKGPI-KSLSLSIKMLDKIWRPDTYF 195
            ...|..::.:.|:..:||:|||::|..|.|.||:|:||:|.... ||::...:::.|||.||.:|
Human    76 AIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDVFF 140

  Fly   196 YNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQ 260
            .:.|.|..|..|..|.:||:..:|.:|||||:|:.|.|.|:..:||:|.|:|.|.:.||.|.::.
Human   141 VHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYAYTDED 205

  Fly   261 LIYEWKNQDDAVSFVPGMTLNQFDLISMMHRNFTTVR-----REGDFSVLHVAFNLKRHTGYFLI 320
            |:..|||.|:::.....::|:|| ||...|   ||.|     ..|.::.|::.|.|:||..:||:
Human   206 LMLYWKNGDESLKTDEKISLSQF-LIQKFH---TTSRLAFYSSTGWYNRLYINFTLRRHIFFFLL 266

  Fly   321 QVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMS 385
            |.|.|..|:|:||||||||.|.|...||||.:|:|||::||.......:|:|.|..|:|.:|.:|
Human   267 QTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSYVKAVDIYLWVS 331

  Fly   386 FLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSS 450
            |::...::||:|.|:|.|.:...:..:|.:::.  |:...|......:||
Human   332 FVFVFLSVLEYAAVNYLTTVQERKERKLREKFP--CMCGMLHSKTMMLDG--------------- 379

  Fly   451 NGSENDDNEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYI 515
                                             .|..|..|||||              ...|:|
Human   380 ---------------------------------SYSESEANSLAG--------------YPRSHI 397

  Fly   516 LPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQK---SEQGGANCYVNSVSLIDR 577
            |       |:.|......:|           .....|.|||.:|   ..|.|...:.|: ..||:
Human   398 L-------TEEERQDKIVVH-----------LGLSGEANAARKKGLLKGQTGFRIFQNT-HAIDK 443

  Fly   578 VARIAFPMSFAFLNLLYW 595
            .:|:.||.|:.|.||:||
Human   444 YSRLIFPASYIFFNLIYW 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	156/513 (30%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	68/187 (36%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
GABRR2	NP_002034.3	LIC	51..464	CDD:455710	156/508 (31%)
		LGIC_ECD_GABAAR_rho	76..261	CDD:349806	69/188 (37%)
		Cys-loop	178..192	CDD:349806	6/13 (46%)