DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and GABRG3

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_011519732.1	Gene:	GABRG3 / 2567	HGNCID:	4088	Length:	473	Species:	Homo sapiens

Alignment Length:	538	Identity:	170/538 - (31%)
Similarity:	259/538 - (48%)	Gaps:	89/538 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 NGSLKRSQNATNLSYSSSEISNQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTV 134
            :|...||:......|..|. |||:.|....:.|   .::::||..||:.|::...|..|. .|||
Human    13 SGLHARSRKVEEDEYEDSS-SNQKWVLAPKSQD---TDVTLILNKLLREYDKKLRPDIGI-KPTV 72

  Fly   135 VQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGK 199
            :..:|.:.|:||||.::|:|.:|.:|.|.|.|.||.|...:|.|:|:..|:..||.|||.|.|.|
Human    73 IDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSK 137

  Fly   200 HSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYE 264
            .::.|.||.||:|||:..:|.|||::||||.|.|.::|.|||||..||||:..||||..:::||.
Human   138 TAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPKEEMIYR 202

  Fly   265 WKNQDDAVSFVPGMTLNQFDLISMMHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILI 329
            |:......:......|.|||.:.:.:.........||:.|:.:.|.|.|..|||.||.|:||||.
Human   203 WRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDYVVMTIYFELSRRMGYFTIQTYIPCILT 267

  Fly   330 VVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLL 394
            ||||||||||.::||..|.:|.:|:|||::|:|..:|..||:|.|.||:|.|:.:.||:..|.|:
Human   268 VVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALM 332

  Fly   395 EFAGVHYFTKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNE 459
            |:|.::|::   |...|....:...:.                                 :.|:.
Human   333 EYATLNYYS---SCRKPTTTKKTTSLL---------------------------------HPDSS 361

  Fly   460 AGASESVESKSGVCVCNKNDALGLEYEVSLQN-SLAG------AGFLKRNAIFCPTYNDPSYILP 517
            ....|.:..::.            ...::||| ||..      |.....|:::...:.|
Human   362 RWIPERISLQAP------------SVRIALQNYSLLDMRPPPTAMITLNNSVYWQEFED------ 408

  Fly   518 NTMERTTQTEPPAVSRLHQMWMCLK--SDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVAR 580
                 |...|..........:.|.:  ...|:||.|               .:::.:.| |..:|
Human   409 -----TCVYECLDGKDCQSFFCCYEECKSGSWRKGR---------------IHIDILEL-DSYSR 452

  Fly   581 IAFPMSFAFLNLLYWWAY 598
            :.||.||...||:||..|
Human   453 VFFPTSFLLFNLVYWVGY 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	162/514 (32%)
		Neur_chan_LBD	111..315	CDD:280998	83/203 (41%)
		Neur_chan_memb	322..>403	CDD:280999	41/80 (51%)
GABRG3	XP_011519732.1	Neur_chan_LBD	48..253	CDD:280998	83/205 (40%)
		LIC	50..470	CDD:273305	159/495 (32%)
		Neur_chan_memb	260..467	CDD:280999	69/281 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41856
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.920