DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and GABRG2

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_944493.2	Gene:	GABRG2 / 2566	HGNCID:	4087	Length:	515	Species:	Homo sapiens

Alignment Length:	535	Identity:	163/535 - (30%)
Similarity:	246/535 - (45%)	Gaps:	130/535 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 NISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSF 171
            ::::||.|||:.|:....|..|. .||::.|::.:.|:|||:.::|:|::|.:|.|.|.|:||.|
Human    65 DVTVILNNLLEGYDNKLRPDIGV-KPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKF 128

  Fly   172 KGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPME 236
            ...||.|.|:..|:.|||.|||:|.|.|.:..|.||.||::||:..:|.:||::||||.|.|.::
Human   129 NSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQ 193

  Fly   237 LQNFPMDRQSCPLVIGSY----------------------------------------GYINQQL 261
            |.|||||..||||...|:                                        ||..:::
Human   194 LHNFPMDEHSCPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPREEI 258

  Fly   262 IYEWKNQDDAVSFVPGMTLNQFDLISMMHRNFTTVRR--EGDFSVLHVAFNLKRHTGYFLIQVYV 324
            :|:||.....|.......|.||..:.:  ||.|.|.:  .||:.|:.|.|:|.|..|||.||.|:
Human   259 VYQWKRSSVEVGDTRSWRLYQFSFVGL--RNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYI 321

  Fly   325 PCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYC 389
            ||.||||||||||||:::|...|.||.:|:|||::|:|..:|..||||.|.||:|.|:.:.|::.
Human   322 PCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFV 386

  Fly   390 IATLLEFAGVHYFTKLGSGESPQLE-DQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGS 453
            .:.|:|:..:|||.   |...|..: |:.:...:....|..|            |..|....:.:
Human   387 FSALVEYGTLHYFV---SNRKPSKDKDKKKKNPLLRMFSFKA------------PTIDIRPRSAT 436

  Fly   454 ENDDNEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPN 518
            ...:|.....|..|.....|:..|:.|                      :.|| .:.|
Human   437 IQMNNATHLQERDEEYGYECLDGKDCA----------------------SFFC-CFED------- 471

  Fly   519 TMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAF 583
                 .:|......|:|                                  ..::.:|..|||.|
Human   472 -----CRTGAWRHGRIH----------------------------------IRIAKMDSYARIFF 497

  Fly   584 PMSFAFLNLLYWWAY 598
            |.:|...||:||.:|
Human   498 PTAFCLFNLVYWVSY 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	162/533 (30%)
		Neur_chan_LBD	111..315	CDD:280998	86/245 (35%)
		Neur_chan_memb	322..>403	CDD:280999	40/80 (50%)
GABRG2	NP_944493.2	LIC	69..512	CDD:273305	162/529 (31%)
		Neur_chan_LBD	69..312	CDD:280998	86/245 (35%)
		Neur_chan_memb	319..509	CDD:280999	69/273 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41856
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3154
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.950