Protein Alignment CG8916 and GABRE

DIOPT Version :9

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_004952.2
• Gene: GABRE / 2564
• HGNCID: 4085
• Length: 506
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 170/574 - (29%)
• Similarity: 263/574 - (45%)
• Gaps: 95/574 - (16%)

  Fly    29 LLYIKTMGPSAILTKMPNITNEFSSR--IFSSFRILPSSKPKTNGSLKRSQNATNLSYSSSEISN 91
            :|..:..||..      ...||.|||  ::.     |..:|..|..|.....:|       |...
Human    15 ILQSRVEGPQT------ESKNEASSRDVVYG-----PQPQPLENQLLSEETKST-------ETET 61

  Fly    92 QRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSM 156
            ..||.:...|       |.||..:|..|:....|..|: .||||...|.:.|:||:|.|||:|::
Human    62 GSRVGKLPEA-------SRILNTILSNYDHKLRPGIGE-KPTVVTVEISVNSLGPLSILDMEYTI 118

  Fly   157 DCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGI 221
            |..|.|.|.|:||.:....:||.|:..::.::|.|||:|.|.|.:..|.||:||:::|:.::|.:
Human   119 DIIFSQTWYDERLCYNDTFESLVLNGNVVSQLWIPDTFFRNSKRTHEHEITMPNQMVRIYKDGKV 183

  Fly   222 LYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDLI 286
            ||::|:||.|.|.:.:..||||..||||...|:.|...::||:|:|....::......|.|||..
Human   184 LYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWENFKLEINEKNSWKLFQFDFT 248

  Fly   287 SMMHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLC 351
            .:.::........|||.|:.:.||:.|..||...|.|||..:..:||||||||..|:...|.||.
Human   249 GVSNKTEIITTPVGDFMVMTIFFNVSRRFGYVAFQNYVPSSVTTMLSWVSFWIKTESAPARTSLG 313

  Fly   352 VTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHY--FTKLGSGESPQL- 413
            :|||||::|:...||.:.|:|.|.||||:::.:.|::|...|||||.:::  :.:..:..||:|
Human   314 ITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVFCFCALLEFAVLNFLIYNQTKAHASPKLR 378

  Fly   414 EDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGV-CVCNK 477
            ..:......|.:.:..........||........:.|:|.|.....|....|..|..|. .:|:|
Human   379 HPRINSRAHARTRARSRACARQHQEAFVCQIVTTEGSDGEERPSCSAQQPPSPGSPEGPRSLCSK 443

  Fly   478 NDALGLEYEVSLQNSLAGAGFLKR-NAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCL 541
                           ||...:.|| ...||        ::|:....|.|          |..:|:
Human   444 ---------------LACCEWCKRFKKYFC--------MVPDCEGSTWQ----------QGRLCI 475

  Fly   542 KSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYW 595
                                         .|..:|..:|:.||::|.|.|:|||
Human   476 -----------------------------HVYRLDNYSRVVFPVTFFFFNVLYW 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	156/509 (31%)
		Neur_chan_LBD	111..315	CDD:280998	75/203 (37%)
		Neur_chan_memb	322..>403	CDD:280999	37/82 (45%)
GABRE	NP_004952.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..66		13/60 (22%)
		Neur_chan_LBD	71..276	CDD:280998	76/212 (36%)
		Neur_chan_memb	285..>408	CDD:280999	43/122 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..438		7/24 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920