Protein Alignment CG8916 and GABRB1

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_000803.2
• Gene: GABRB1 / 2560
• HGNCID: 4081
• Length: 474
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 166/526 - (31%)
• Similarity: 266/526 - (50%)
• Gaps: 88/526 - (16%)

  Fly    83 SYSSSEISNQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPV 147
            ::|::|.||...|:.             .::.|||.|:....|..| |.|..|...|.:.|:..|
Human    25 AHSTNEPSNMSYVKE-------------TVDRLLKGYDIRLRPDFG-GPPVDVGMRIDVASIDMV 75

  Fly   148 SELDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKL 212
            ||::|||::..||:|.|:|||||:.|...:|:|..::.|::|.|||||.|.|.|.:|.:||.|::
Human    76 SEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 140

  Fly   213 LRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPG 277
            :||..:|.:||.:|:|..|.|.|:|:.:|:|.|:|.|.|.||||....:.:.|...:.||:.|..
Human   141 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNK 205

  Fly   278 MTLNQFDLI--SMMHR--NFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFW 338
            :.|.||.::  .|:.:  .|||    |.:..|.::|.|||:.|||::|.|:|..||.:|||||||
Human   206 IELPQFSIVDYKMVSKKVEFTT----GAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFW 266

  Fly   339 IHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYF- 402
            |:.:|::.||:|.:|:|||::|||...|..|||:.|..|:|.:|:..|::....|||:|.|:|.
Human   267 INYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIF 331

  Fly   403 -----TKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGA 462
                 .|.|:.:..|..::      .|.|..:..:||..|..........:.::|||...:.:..
Human   332 FGKGPQKKGASKQDQSANE------KNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDP 390

  Fly   463 SESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTE 527
            ..::.|         .|:..::|...|.:..|....|.|:.:       ||
Human   391 KATMYS---------YDSASIQYRKPLSSREAYGRALDRHGV-------PS-------------- 425

  Fly   528 PPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNL 592
                                 |.|.|..|:|...:......|||   ||:.:|:.||::|:..|:
Human   426 ---------------------KGRIRRRASQLKVKIPDLTDVNS---IDKWSRMFFPITFSLFNV 466

  Fly   593 LYWWAY 598
            :||..|
Human   467 VYWLYY 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	161/515 (31%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	73/185 (39%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
GABRB1	NP_000803.2	LIC	9..472	CDD:273305	165/524 (31%)