Protein Alignment CG8916 and GABRA6

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 181/501 - (36%)
• Similarity: 260/501 - (51%)
• Gaps: 96/501 - (19%)

  Fly   105 SRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRL 169
            |.|:|.||:|||:.|:....|..| |..|.|:|:|.:.|.||||:::|:|:||.:|||.|.|:||
Human    29 SENVSRILDNLLEGYDNRLRPGFG-GAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERL 92

  Fly   170 SFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCP 234
            .|.||.:.|||:..|:.|||.|||:|.|||.|..|.:|.||||.|:.|||.|||:|||||.|.||
Human    93 KFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCP 157

  Fly   235 MELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVP--GMTLNQFDLISMMHRNFTTVR 297
            |.|.|||||..:|||..|||.|...::||.||........||  ..:|.|:|||.....:.|...
Human   158 MRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKS 222

  Fly   298 REGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTIS 362
            ..|::.::.|.|:|:|..|||:||:|.|||:.|:||.|||||::|:...|....:|:|||::|:|
Human   223 NTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLS 287

  Fly   363 LDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLS 427
            :.:|..||||.||||:|||:.:.|.:..:.|:|||.|:|||.|.:.::.:...
Human   288 ISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQ------------ 340

  Fly   428 DHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEYEVS---- 488
                            ||...:...|:       |:|.:|::   .|.:.:....|:..::
Human   341 ----------------FAAPPTVTISK-------ATEPLEAE---IVLHPDSKYHLKKRITSLSL 379

  Fly   489 -LQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQRE 552
             :.:|......|.|..|.                ::|...||.:|...
Human   380 PIVSSSEANKVLTRAPIL----------------QSTPVTPPPLSPAF----------------- 411

  Fly   553 RNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
                      ||       .|.||:.:||.||::||..||:||..|
Human   412 ----------GG-------TSKIDQYSRILFPVAFAGFNLVYWVVY 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	180/499 (36%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	89/183 (49%)
		Cys-loop	233..247	CDD:349808	9/13 (69%)
GABRA6	NP_000802.2	LIC	5..440	CDD:455710	180/499 (36%)
		LGIC_ECD_GABAAR_A6	42..239	CDD:349840	93/197 (47%)
		Cys-loop	156..170	CDD:349840	9/13 (69%)