Protein Alignment CG8916 and GABRA6

DIOPT Version :9

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_000802.2
• Gene: GABRA6 / 2559
• HGNCID: 4080
• Length: 453
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 181/501 - (36%)
• Similarity: 260/501 - (51%)
• Gaps: 96/501 - (19%)

  Fly   105 SRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRL 169
            |.|:|.||:|||:.|:....|..| |..|.|:|:|.:.|.||||:::|:|:||.:|||.|.|:||
Human    29 SENVSRILDNLLEGYDNRLRPGFG-GAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERL 92

  Fly   170 SFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCP 234
            .|.||.:.|||:..|:.|||.|||:|.|||.|..|.:|.||||.|:.|||.|||:|||||.|.||
Human    93 KFGGPTEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCP 157

  Fly   235 MELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVP--GMTLNQFDLISMMHRNFTTVR 297
            |.|.|||||..:|||..|||.|...::||.||........||  ..:|.|:|||.....:.|...
Human   158 MRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKS 222

  Fly   298 REGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTIS 362
            ..|::.::.|.|:|:|..|||:||:|.|||:.|:||.|||||::|:...|....:|:|||::|:|
Human   223 NTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLS 287

  Fly   363 LDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLS 427
            :.:|..||||.||||:|||:.:.|.:..:.|:|||.|:|||.|.:.::.:...
Human   288 ISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAKRKAQ------------ 340

  Fly   428 DHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEYEVS---- 488
                            ||...:...|:       |:|.:|::   .|.:.:....|:..::
Human   341 ----------------FAAPPTVTISK-------ATEPLEAE---IVLHPDSKYHLKKRITSLSL 379

  Fly   489 -LQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQRE 552
             :.:|......|.|..|.                ::|...||.:|...
Human   380 PIVSSSEANKVLTRAPIL----------------QSTPVTPPPLSPAF----------------- 411

  Fly   553 RNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
                      ||       .|.||:.:||.||::||..||:||..|
Human   412 ----------GG-------TSKIDQYSRILFPVAFAGFNLVYWVVY 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	180/499 (36%)
		Neur_chan_LBD	111..315	CDD:280998	99/205 (48%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
GABRA6	NP_000802.2	Neur_chan_LBD	5..440	CDD:332142	180/499 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20220
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2115
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm41856
orthoMCL	1	0.900	-	-		OOG6_105663
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3154
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900