Protein Alignment CG8916 and GABRA5

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_000801.1
• Gene: GABRA5 / 2558
• HGNCID: 4079
• Length: 462
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 177/504 - (35%)
• Similarity: 266/504 - (52%)
• Gaps: 102/504 - (20%)

  Fly   102 DMLSRNISM---ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQY 163
            |..:.||::   ||:.||..|:....|..|:.: |.|:|:|.:.|.||||:.:|:|::|.:|||.
Human    40 DETNDNITIFTRILDGLLDGYDNRLRPGLGERI-TQVRTDIYVTSFGPVSDTEMEYTIDVFFRQS 103

  Fly   164 WRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLT 228
            |:|:||.||||::.|.|:..:..|||.|||:|:|||.|..|.:|.|||||||:.:|.:||:||||
Human   104 WKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLT 168

  Fly   229 IKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKN--QDDAVSFVPGMTLNQFDLI--SMM 289
            |.|.|||:|::||||..:|||..|||.|.|.:::|.|.|  ....|....|..|||:.|:  ::.
Human   169 ISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVG 233

  Fly   290 HRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTS 354
            ..|.:|  ..|:::::...|:|||..|||:||.|:|||:.|:||.||||::||:...|....||:
Human   234 TENIST--STGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTT 296

  Fly   355 VLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWED 419
            |||::|:|:.:|..||||.||||:|||:.:.:.:..:.|:|||.|:||||.|..        |
Human   297 VLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWA--------W-- 351

  Fly   420 ICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLE 484
                                                |..:|..:..::.|..| :.||:
Human   352 ------------------------------------DGKKALEAAKIKKKREV-ILNKS------ 373

  Fly   485 YEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRK 549
                            .||......:.|    ||..:..|   |...|....:        |.:.
Human   374 ----------------TNAFTTGKMSHP----PNIPKEQT---PAGTSNTTSV--------SVKP 407

  Fly   550 QRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
            ..|:.:.::|:        .||:|.||:::||.||:.|...||:||..|
Human   408 SEEKTSESKKT--------YNSISKIDKMSRIVFPVLFGTFNLVYWATY 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	176/502 (35%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	85/185 (46%)
		Cys-loop	233..247	CDD:349808	8/13 (62%)
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	88/200 (44%)
		Cys-loop	173..187	CDD:349839	8/13 (62%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	77/277 (28%)
		TM1 helix	259..282	CDD:349854	15/22 (68%)
		TM2 helix	286..310	CDD:349854	9/23 (39%)
		TM3 helix	318..344	CDD:349854	10/25 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		8/49 (16%)
		TM4 helix	421..445	CDD:349854	11/23 (48%)