DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and GABRA5

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_000801.1	Gene:	GABRA5 / 2558	HGNCID:	4079	Length:	462	Species:	Homo sapiens

Alignment Length:	504	Identity:	177/504 - (35%)
Similarity:	266/504 - (52%)	Gaps:	102/504 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DMLSRNISM---ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQY 163
            |..:.||::   ||:.||..|:....|..|:.: |.|:|:|.:.|.||||:.:|:|::|.:|||.
Human    40 DETNDNITIFTRILDGLLDGYDNRLRPGLGERI-TQVRTDIYVTSFGPVSDTEMEYTIDVFFRQS 103

  Fly   164 WRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLT 228
            |:|:||.||||::.|.|:..:..|||.|||:|:|||.|..|.:|.|||||||:.:|.:||:||||
Human   104 WKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLT 168

  Fly   229 IKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKN--QDDAVSFVPGMTLNQFDLI--SMM 289
            |.|.|||:|::||||..:|||..|||.|.|.:::|.|.|  ....|....|..|||:.|:  ::.
Human   169 ISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVG 233

  Fly   290 HRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTS 354
            ..|.:|  ..|:::::...|:|||..|||:||.|:|||:.|:||.||||::||:...|....||:
Human   234 TENIST--STGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTT 296

  Fly   355 VLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWED 419
            |||::|:|:.:|..||||.||||:|||:.:.:.:..:.|:|||.|:||||.|..        |
Human   297 VLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWA--------W-- 351

  Fly   420 ICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLE 484
                                                |..:|..:..::.|..| :.||:
Human   352 ------------------------------------DGKKALEAAKIKKKREV-ILNKS------ 373

  Fly   485 YEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRK 549
                            .||......:.|    ||..:..|   |...|....:        |.:.
Human   374 ----------------TNAFTTGKMSHP----PNIPKEQT---PAGTSNTTSV--------SVKP 407

  Fly   550 QRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
            ..|:.:.::|:        .||:|.||:::||.||:.|...||:||..|
Human   408 SEEKTSESKKT--------YNSISKIDKMSRIVFPVLFGTFNLVYWATY 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	176/502 (35%)
		Neur_chan_LBD	111..315	CDD:280998	93/207 (45%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	88/200 (44%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	77/277 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..412		8/49 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2115
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm41856
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.970