Protein Alignment CG8916 and GABRA3

DIOPT Version :9

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_000799.1
• Gene: GABRA3 / 2556
• HGNCID: 4077
• Length: 492
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 195/602 - (32%)
• Similarity: 290/602 - (48%)
• Gaps: 133/602 - (22%)

  Fly    24 VTSSDLLYIKTMGPSAILTKMPNITNEFSSRIFSSFRILPSSKPKTN-GSLKRSQNATNLSYSSS 87
            :|.:...|:.::|...::..:|..|.:..||     |..|....|.: |.|. .::|.::...|:
Human     3 ITQTSHCYMTSLGILFLINILPGTTGQGESR-----RQEPGDFVKQDIGGLS-PKHAPDIPDDST 61

  Fly    88 EISNQRRVRRKAAADMLSRNISM---ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSE 149
            :                  ||::   ||:.||..|:....|..|..| |.|:|:|.:.|.||||:
Human    62 D------------------NITIFTRILDRLLDGYDNRLRPGLGDAV-TEVKTDIYVTSFGPVSD 107

  Fly   150 LDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLR 214
            .||:|::|.:|||.|.|:||.|.||:|.|.|:..:..|||.|||:|:|||.|..|.:|.||||||
Human   108 TDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLR 172

  Fly   215 LDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEW---KNQDDAVSFVP 276
            |..||.:||:|||||.|.|||.|::||||..:|||..|||.|...:::|.|   ||:...|: ..
Human   173 LVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVA-QD 236

  Fly   277 GMTLNQFDLISMMHRNFTTVRRE--GDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWI 339
            |..|||:||:.  |...|.:.|.  |::.|:...|:|||..|||:||.|:|||:.|:||.||||:
Human   237 GSRLNQYDLLG--HVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWL 299

  Fly   340 HREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTK 404
            :||:...|....||:|||::|:|:.:|..||||.||||:|||:.:.:.:..:.|:|||.|:||||
Human   300 NRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTK 364

  Fly   405 LGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESK 469
            ....        ||...:..:|                                      .::.|
Human   365 RSWA--------WEGKKVPEAL--------------------------------------EMKKK 383

  Fly   470 SGVCVCNKN----DALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPA 530
            :......|.    :.:|..|.::|......:...|..|   |:.:....|:.:......|..|..
Human   384 TPAAPAKKTSTTFNIVGTTYPINLAKDTEFSTISKGAA---PSASSTPTIIASPKATYVQDSPTE 445

  Fly   531 VSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYW 595
            ...                                   .||||.:|:::||.||:.||..||:||
Human   446 TKT-----------------------------------YNSVSKVDKISRIIFPVLFAIFNLVYW 475

  Fly   596 WAY--------GMYKKE 604
            ..|        ||.:|:
Human   476 ATYVNRESAIKGMIRKQ 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	177/517 (34%)
		Neur_chan_LBD	111..315	CDD:280998	99/208 (48%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
GABRA3	NP_000799.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..54		7/31 (23%)
		LIC	69..478	CDD:273305	175/496 (35%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	95/202 (47%)
		Cys-loop	191..205	CDD:349837	8/13 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2115
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm41856
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.970