DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and GABRA2

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001317619.1	Gene:	GABRA2 / 2555	HGNCID:	4076	Length:	511	Species:	Homo sapiens

Alignment Length:	548	Identity:	196/548 - (35%)
Similarity:	275/548 - (50%)	Gaps:	113/548 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 RRVRRKAAADMLSRNISM---ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDY 154
            |.|......|....||::   ||:.||..|:....|..|..: |.|.|||.:.|.||||:.||:|
Human    24 RLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSI-TEVFTNIYVTSFGPVSDTDMEY 87

  Fly   155 SMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNG 219
            ::|.:|||.|:|:||.||||:..|.|:..|..|||.|||:|:|||.|..|.:|:||||||:..:|
Human    88 TIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDG 152

  Fly   220 GILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWK-NQDDAVSFVP-GMTLNQ 282
            .:||:||||::|.|||.|::||||..||||..|||.|...::.|.|. |..|:|...| |..|||
Human   153 TLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQ 217

  Fly   283 FDLISMMHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDR 347
            :||:.......|.....|:::|:...|:|||..|||:||.|:|||:.|:||.||||::||:...|
Human   218 YDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 282

  Fly   348 VSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQ 412
            ....||:|||::|:|:.:|..||||.||||:|||:.:.:.:..:.|:|||.|:||||.|..
Human   283 TVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWA---- 343

  Fly   413 LEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNK 477
                |:...:.|               |..|                     |:          |
Human   344 ----WDGKSVVN---------------DKSP---------------------SI----------K 358

  Fly   478 NDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWM-CL 541
            .:.:.|.|. |::..|.||..:....|   .::.||.....|:|..            :.|| ||
Human   359 AEGITLTYN-SVKAILQGAKLIWSKYI---AFSWPSLFQEKTLEYL------------EKWMDCL 407

  Fly   542 KSDNSFRKQR-----ERNAAA-----------------------------QKSEQGGANC--YVN 570
            ....|.:|::     :.||.|                             :|.|...|..  ..|
Human   408 TFKQSSKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFN 472

  Fly   571 SVSLIDRVARIAFPMSFAFLNLLYWWAY 598
            |||.|||::||.||:.|...||:||..|
Human   473 SVSKIDRMSRIVFPVLFGTFNLVYWATY 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	195/546 (36%)
		Neur_chan_LBD	111..315	CDD:280998	97/205 (47%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
GABRA2	NP_001317619.1	LIC	25..500	CDD:273305	194/545 (36%)
GABRA2	NP_001317619.1	LGIC_ECD_GABAAR_A2	47..249	CDD:349836	94/202 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2115
Isobase	1	0.950	-	0	Normalized mean entropy	S4379
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm41856
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3154
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.050