Protein Alignment CG8916 and GABRA1

DIOPT Version :9

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_000797.2
• Gene: GABRA1 / 2554
• HGNCID: 4075
• Length: 456
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 183/512 - (35%)
• Similarity: 261/512 - (50%)
• Gaps: 117/512 - (22%)

  Fly   102 DMLSRNISM---ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQY 163
            |.|..|.::   ||:.||..|:....|..|:.| |.|:|:|.:.|.||||:.||:|::|.:|||.
Human    33 DELKDNTTVFTRILDRLLDGYDNRLRPGLGERV-TEVKTDIFVTSFGPVSDHDMEYTIDVFFRQS 96

  Fly   164 WRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLT 228
            |:|:||.||||:..|.|:..|..|||.|||:|:|||.|..|.:|:||||||:.::|.:||:||||
Human    97 WKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLT 161

  Fly   229 IKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFV---PGMTLNQFDLISMMH 290
            ::|.|||.|::||||..:|||..|||.|...:::||| .::.|.|.|   .|..|||:||:....
Human   162 VRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEW-TREPARSVVVAEDGSRLNQYDLLGQTV 225

  Fly   291 RNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSV 355
            .:.......|::.|:...|:|||..|||:||.|:|||:.|:||.||||::||:...|....||:|
Human   226 DSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTV 290

  Fly   356 LTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDI 420
            ||::|:|:.:|..||||.||||:|||:.:.:.:..:.|:|||.|:||||.|..        |
Human   291 LTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYA--------W--- 344

  Fly   421 CIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEY 485
                         ||.......|...:|.
Human   345 -------------DGKSVVPEKPKKVKDP------------------------------------ 360

  Fly   486 EVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPN---------TMERTTQTEPPAVSRLHQMWMCL 541
                        .:|:|..:.||..  || .||         |:.::...||..|
Human   361 ------------LIKKNNTYAPTAT--SY-TPNLARGDPGLATIAKSATIEPKEV---------- 400

  Fly   542 KSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
                   |...:....:|:        .||||.|||::|||||:.|...||:||..|
Human   401 -------KPETKPPEPKKT--------FNSVSKIDRLSRIAFPLLFGIFNLVYWATY 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	182/510 (36%)
		Neur_chan_LBD	111..315	CDD:280998	95/206 (46%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
GABRA1	NP_000797.2	LIC	14..442	CDD:273305	182/510 (36%)
		LGIC_ECD_GABAAR_A1	56..249	CDD:349835	89/194 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2115
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm41856
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3154
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	10.000