Protein Alignment CG8916 and Gabra3

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_058765.3
• Gene: Gabra3 / 24947
• RGDID: 2648
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 613
• Identity: 200/613 - (32%)
• Similarity: 296/613 - (48%)
• Gaps: 148/613 - (24%)

  Fly    15 MAHFCACEDVTSSDLLYIKTMGPSAILTKMPNITNEFSSRIFSSFRILPSSKPKTN-GSLKRSQN 78
            |.||            |:..:|...:::.:|..|.:..||     |..|....|.: |.|. .::
  Rat     6 MWHF------------YVTRVGLLLLISILPGTTGQGESR-----RQEPGDFVKQDIGGLS-PKH 52

  Fly    79 ATNLSYSSSEISNQRRVRRKAAADMLSRNISM---ILENLLKRYEQSQLPTHGQGVPTVVQTNIL 140
            |.::...|::                  ||::   ||:.||..|:....|..|..| |.|:|:|.
  Rat    53 APDIPDDSTD------------------NITIFTRILDRLLDGYDNRLRPGLGDAV-TEVKTDIY 98

  Fly   141 IRSMGPVSELDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHM 205
            :.|.||||:.||:|::|.:|||.|.|:||.|.||:|.|.|:..:..|||.|||:|:|||.|..|.
  Rat    99 VTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHN 163

  Fly   206 ITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEW---KN 267
            :|.|||||||..||.:||:|||||.|.|||.|::||||..:|||..|||.|...::||.|   ||
  Rat   164 MTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKN 228

  Fly   268 QDDAVSFVPGMTLNQFDLISMMHRNFTTVRRE--GDFSVLHVAFNLKRHTGYFLIQVYVPCILIV 330
            :...|: ..|..|||:||:.  |...|.:.|.  |::.|:...|:|||..|||:||.|:|||:.|
  Rat   229 KSVEVA-QDGSRLNQYDLLG--HVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTV 290

  Fly   331 VLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLE 395
            :||.||||::||:...|....||:|||::|:|:.:|..||||.||||:|||:.:.:.:..:.|:|
  Rat   291 ILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIE 355

  Fly   396 FAGVHYFTKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEA 460
            ||.|:||||....        ||...:..:|
  Rat   356 FATVNYFTKRSWA--------WEGKKVPEAL---------------------------------- 378

  Fly   461 GASESVESKSGVCVCNKN----DALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYIL--PNT 519
                .::.|:......|.    :.:|..|.::|......:...|  |...|:.:....::  |.|
  Rat   379 ----EMKKKTPAAPTKKTSTTFNIVGTTYPINLAKDTEFSTISK--AAAAPSASSTPTVIASPKT 437

  Fly   520 MERTTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFP 584
               |...:.||.::.:                                  ||||.:|:::||.||
  Rat   438 ---TYVQDSPAETKTY----------------------------------NSVSKVDKISRIIFP 465

  Fly   585 MSFAFLNLLYWWAY--------GMYKKE 604
            :.||..||:||..|        ||.:|:
  Rat   466 VLFAIFNLVYWATYVNRESAIKGMIRKQ 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	180/519 (35%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	91/186 (49%)
		Cys-loop	233..247	CDD:349808	8/13 (62%)
Gabra3	NP_058765.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..54		8/32 (25%)
		LIC	69..479	CDD:455710	178/498 (36%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	96/202 (48%)
		Cys-loop	191..205	CDD:349837	8/13 (62%)