Protein Alignment CG8916 and Gabrr3

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_620252.1
• Gene: Gabrr3 / 192258
• RGDID: 621564
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 532
• Identity: 148/532 - (27%)
• Similarity: 236/532 - (44%)
• Gaps: 130/532 - (24%)

  Fly    92 QRRVRR-KAAADMLSRNISMILENLL--KRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMD 153
            |.|:|. :...|.|::...:..|.||  :.::.|..|..| |.|..|..::.:.|:..:||::||
  Rat    37 QTRIRETRMRKDDLTKVWPLKREQLLHIEDHDFSTRPGFG-GSPVPVGIDVQVESIDSISEVNMD 100

  Fly   154 YSMDCYFRQYWRDKRLSFKGPI-KSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQ 217
            ::|..|.|.||:|:||||.... ||::...:::.|||.||.:|.:.|.|.||..||.|.:||:..
  Rat   101 FTMTFYLRHYWKDERLSFPSTTNKSMTFDRRLIQKIWVPDIFFVHSKRSFIHDTTVENIMLRVHP 165

  Fly   218 NGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQ 282
            :|.:|:|:|:|:.|.|.|:...||:|.|:|.|.:.||.|..:.|:..||:.:.:::....::|:|
  Rat   166 DGNVLFSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEEDLMLYWKHGNKSLNTEEHISLSQ 230

  Fly   283 FDLISMMHRNFTT------VRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHR 341
            |.:     ..|:.      ....|.:..|.:.|.|:||..:|::|.|.|.:|:|:||||||||.|
  Rat   231 FFI-----EEFSASSGLAFYSSTGWYYRLFINFVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDR 290

  Fly   342 EATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLG 406
            .|...||||.:|:|||:|||.......:|:|.|..|:|.::.:|.|:...:::|:|.|:|.|.:
  Rat   291 RAVPARVSLGITTVLTMSTIVTGVSASMPQVSYVKAVDVYMWVSSLFVFLSVIEYAAVNYLTTV- 354

  Fly   407 SGESPQLEDQWEDICIANSLSD-------HAGEVDG---DGEADADP-----FADEDSSNGSEND 456
                    ::|:.:.....:|.       .|...||   |||.|.|.     .::|||.
  Rat   355 --------EEWKQLNRRGKISGMYNIDAVQAMAFDGCYHDGETDVDQTSFFLHSEEDSM------ 405

  Fly   457 DNEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTME 521
                                                                             
  Rat   406 ----------------------------------------------------------------- 405

  Fly   522 RTTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMS 586
            ||..|..|          |..|....||....|.         ....:.:..:||..:||.||:.
  Rat   406 RTKFTGSP----------CADSSQIKRKSLGGNV---------GRIILENNHVIDTYSRIVFPVV 451

  Fly   587 FAFLNLLYWWAY 598
            :...||.||..|
  Rat   452 YIIFNLFYWGIY 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	147/530 (28%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	62/188 (33%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
Gabrr3	NP_620252.1	LIC	58..463	CDD:455710	142/509 (28%)
		LGIC_ECD	79..264	CDD:475126	63/189 (33%)
		Interaction with SQSTM1. /evidence=ECO:0000269|PubMed:12431995	344..445		29/199 (15%)