DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and acc-2

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_501567.1	Gene:	acc-2 / 183758	WormBaseID:	WBGene00008280	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	136/553 - (24%)
Similarity:	231/553 - (41%)	Gaps:	151/553 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 TNLSYS----SSE-ISNQRRVRRKA--AADMLSRNISMILENLLK--RYEQSQLPTHGQGVPTVV 135
            |.|.||    |:| :|:...:..|.  ..|..:|:.. |::.||.  .|.:.::|.. :|:..||
Worm    16 TELDYSELVHSAELVSSSSYIHHKTNKKPDNCTRDTD-IIDRLLNGTGYNKFRIPQE-EGMTVVV 78

  Fly   136 QTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFK--GPIK-SLSLSIKMLDKIWRPDTYFYN 197
            :  |.|:::..:.||..|:.||.|..:.|.|..|:|:  .|.| :|||:.::||::|.|::.|.|
Worm    79 E--IWIQAITSIDELTNDFDMDIYITETWLDPALNFQTMTPCKGNLSLNHQVLDRLWTPNSCFIN 141

  Fly   198 GKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLI 262
            .|.:|||.....:..|.|..||.::.:.|:.:|..|.::|.|||:|.|.|.|:..|:.|..|::.
Worm   142 SKVAQIHNSPFRSVFLMLFPNGTVMVNYRVRVKGPCSLDLSNFPLDLQKCSLIYESFNYNRQEVE 206

  Fly   263 YEWKNQDDAVSFVPGMTLNQFDLISMMHRNFTTVRRE-----GDFSVLHVAFNLKRHTGYFLIQV 322
            ..|.:.:..|..:..:.|..|||..:.     |.||:     |.:..|||....:|...::.:|.
Worm   207 MRWSDAEHPVFNLSKIMLPDFDLFEIQ-----TERRQEPYPAGMWDELHVTIIFERRFIWYFMQA 266

  Fly   323 YVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALD-WFLL-MS 385
            |:|..|.:.:||:||.:...|...|..|.|.|:|.:.....:...:||:|.|...:| |.|: |:
Worm   267 YLPTYLTIFISWISFSLGSRAIPARTMLGVNSLLAIVFSFGNIMRNLPRVSYIKGIDVWMLVSMT 331

  Fly   386 FLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSS 450
            |::|  :|||.|.|.:..:              |..:|......  ::.|:       .:.|:|.
Worm   332 FIFC--SLLELAIVGFMVR--------------DETVAKKKQQK--KISGN-------ISREESP 371

  Fly   451 NGSENDDN---EAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDP 512
            :|..::..   ..|.|||.:|.|.   |.                   :|:
Worm   372 HGIISERRFMFPPGCSESSKSLSS---CT-------------------SGW-------------- 400

  Fly   513 SYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDR 577
                  |.||                                                    ||.
Worm   401 ------TPER----------------------------------------------------IDS 407

  Fly   578 VARIAFPMSFAFLNLLYWWAYGMYKKEFSWSNM 610
            ::.:.||.||...|::||:.| :::||....|:
Worm   408 ISSVMFPFSFFVFNIIYWFYY-IHRKEIIKQNL 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	125/522 (24%)
		Neur_chan_LBD	111..315	CDD:280998	67/213 (31%)
		Neur_chan_memb	322..>403	CDD:280999	28/82 (34%)
acc-2	NP_501567.1	Neur_chan_LBD	51..258	CDD:308532	66/215 (31%)
acc-2	NP_501567.1	Neur_chan_memb	267..>347	CDD:308533	28/81 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810