Protein Alignment CG8916 and lgc-41

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001360683.1
• Gene: lgc-41 / 183331
• WormBaseID: WBGene00008022
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 563
• Identity: 151/563 - (26%)
• Similarity: 245/563 - (43%)
• Gaps: 106/563 - (18%)

  Fly   114 NLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFKGPIKSL 178
            |||:: ..::.||....||..|:..:.:.|:|.....:|.:.:|.|....|:|.||:.......|
 Worm    33 NLLQQ-SNTRPPTANASVPLGVKLGMYLESLGNFRSSEMSFDVDLYVYMSWQDPRLAHNFSDYVL 96

  Fly   179 SLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMD 243
            ..:.::..:||.||.||.|.:.:....:||||..|.:..:|.:.||.|.|:...|.:.|:.:|||
 Worm    97 INNDEIRKQIWLPDLYFANARQASFQEVTVPNFNLFVAPDGTVAYSCRCTLTVACSLNLRYYPMD 161

  Fly   244 RQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDL--ISMMHRNFT-------TVRRE 299
            :|.|.:.:.||.||.:|:...|.:: :.|.|...:.|.:|.:  :|..:.|.:       ...:.
 Worm   162 QQLCSIRVLSYAYIAKQVNVTWFDK-NPVRFNEEIGLPEFQIEHVSNAYCNGSYQYALTENSYKS 225

  Fly   300 GDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLD 364
            .|||.|.....|.|..||.|:|.|:|..|||::|||||||.|.|...||:|..|::::|:|:...
 Worm   226 DDFSCLSGNLFLSRSIGYNLVQSYIPTGLIVMISWVSFWIDRRAVPARVTLSFTTLVSLTTLGNG 290

  Fly   365 SRTDLPKVKYATALD-WF-LLMSFLYCIATLLEFAGVH-YFTKLGSGESPQLEDQWEDICIANSL 426
            .|..||:|.||.|:| |: ..|.|::|  .|||||.:: |..|  |.:...:..:.:.:.:....
 Worm   291 LRFGLPQVSYAKAIDLWYGACMFFVFC--ALLEFATINSYMRK--SEKFDSMAKKMQSVVLTGRT 351

  Fly   427 SDH-----------AGEVDGDGEADA--DPFADEDSSNGSENDDNEAGASESVESKSGVCVC-NK 477
            .|:           ||...|: ..||  |.:....:.||.::.....|   .:..::|..:. .:
 Worm   352 RDYLVRGIKESMRIAGGAAGN-VVDALNDDWCTYSTENGRKSFSAMVG---DIFERAGNAISPRR 412

  Fly   478 NDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYI----------LPNTMERTTQ--TEPPA 530
            |...||:.|.|.:.                 |..|..:          :.|..:..|:  .|.|.
 Worm   413 NRYRGLKTEKSPRG-----------------YGKPDTVQDILSERIKFIDNEFDFDTKEDDEIPG 460

  Fly   531 VSRLHQMWMCLKSDNSFRKQR-----ERNAAAQKSEQGGAN---CYVNSVSL------------- 574
                 .|.|.:..:.|.||..     |....:.|.::.|.|   .|::. ||
 Worm   461 -----NMAMSIYDNVSCRKDEADSSSEETKFSTKPKRNGTNGTRKYIDK-SLNQSGQNDSLIVAT 519

  Fly   575 --------------IDRVARIAFPMSFAFLNLLYWWAYGMYKK 603
                          ||:..|..||.:|...|:.|||.|.:|.|
 Worm   520 YFQISANHSRHALKIDKSCRYLFPAAFLLWNVFYWWYYLVYTK 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	148/556 (27%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	53/190 (28%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
lgc-41	NP_001360683.1	LIC	41..>332	CDD:455710	100/295 (34%)
		LGIC_TM	<527..557	CDD:476813	10/29 (34%)
		TM4 helix	533..554	CDD:349850	7/20 (35%)