DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and gab-1

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_499661.2	Gene:	gab-1 / 176691	WormBaseID:	WBGene00001512	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	581	Identity:	190/581 - (32%)
Similarity:	288/581 - (49%)	Gaps:	75/581 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RIF--SSFRILPSSKPKTNGSLKRSQNATNLSYSSSEISNQRRVRRKAAADMLSRNISMILENLL 116
            |||  |...:|.|:....||: |...|:|:...||| .||:        :..:..|.|.:|.:||
Worm     8 RIFHVSITLLLVSTIFCQNGT-KPHNNSTSDQMSSS-WSNR--------SQTMYSNASSLLSDLL 62

  Fly   117 KRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFKG--PIKSLS 179
            ..|:....|..| |...::..:|:|.|...:||:||||::..|..|||.|:||.:..  ||..::
Worm    63 LDYDIRLRPGFG-GDALLLTMDIIIASFDSISEVDMDYTLTMYLHQYWTDERLRWSNEIPIDEMT 126

  Fly   180 LSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDR 244
            ||.:....||.|||:..|.|||.:|.:|..||:||::.:|.:.|.||||...:|.|.|:|||:|.
Worm   127 LSGEFSQNIWVPDTFLANDKHSYLHEVTERNKMLRINVDGKVAYGMRLTSTLSCSMNLRNFPLDS 191

  Fly   245 QSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDLISMMHRNFTTVRREGDFSVLHVAF 309
            |:|.:.|.||||...:::.:| |...||..|....:.||.:......:.......|.:..|.:.|
Worm   192 QNCTVEIESYGYTTSEVLMKW-NYPLAVHGVEQADVPQFTITGFHTEDSIVSTATGSYQRLSLVF 255

  Fly   310 NLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKY 374
            .|:|..|||:.|.|:||:|||:||||||||:.||||.||:|.:|:|||::|||...|..||::.|
Worm   256 QLRRSVGYFIFQTYLPCVLIVMLSWVSFWINHEATSARVALGITTVLTMTTISTGVRQSLPRISY 320

  Fly   375 ATALDWFLLMSFLYCIATLLEFAGVHYF------TKLGSG-ESP----QLEDQWEDICIANSLSD 428
            ..::|.:|:|.|::..|.|||:|.|:|.      .|.|.| |.|    ..||:...:.:...:.
Worm   321 VKSIDIYLVMCFVFVFAALLEYAAVNYSYWGRERGKGGGGNEWPVNGANKEDRESAVNVQKWVP- 384

  Fly   429 HAGEVDG-----DGEADADPFADEDSSNGSENDDNEAGASESVESKSGV-CVCNKNDALGLEYEV 487
             :|.:||     |...:|...|...|:..::|::.|:.:.....|.|.: .:|...:.:..|.|
Worm   385 -SGLMDGVPQPQDRRVEALEEAMSTSNTAAQNNNFESTSKPKKRSSSPIPPLCRAGNTISEESE- 447

  Fly   488 SLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQR- 551
                                   .|.|  |.....:.:...|..|..|:... ||..:|.|.:|
Worm   448 -----------------------SPDY--PRYSTTSLKGARPHASLNHKTHH-LKGRSSARAKRR 486

  Fly   552 ----ERNAAAQKSEQG-GANC-------YVNSVSLIDRVARIAFPMSFAFLNLLYWWAYGM 600
                ..|.:.::|..| |...       .|..|:|||:.:|:.||:.|...||.||..|.|
Worm   487 MTLARMNVSMKQSISGIGRRARKVIPTIRVRDVNLIDKYSRVVFPVCFIVFNLFYWSYYMM 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	172/537 (32%)
		Neur_chan_LBD	111..315	CDD:280998	74/205 (36%)
		Neur_chan_memb	322..>403	CDD:280999	43/86 (50%)
gab-1	NP_499661.2	LIC	67..545	CDD:273305	166/508 (33%)
		Neur_chan_LBD	68..259	CDD:280998	69/192 (36%)
		Neur_chan_memb	268..542	CDD:280999	90/302 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810