Protein Alignment CG8916 and lgc-46

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_497338.2
• Gene: lgc-46 / 175279
• WormBaseID: WBGene00022106
• Length: 508
• Species: Caenorhabditis elegans
• Alignment Length: 574
• Identity: 132/574 - (22%)
• Similarity: 232/574 - (40%)
• Gaps: 137/574 - (23%)

  Fly    68 KTNGSLKRSQNATNLSYSSSEISNQRRVRRKAAADMLSRNI---SMILENLLKRYEQSQLPTHGQ 129
            :.:.||:|.  ..|..:...|....:.:...|..:..::|.   |.||..::..|.:.::|
 Worm    25 RNSPSLRRL--TRNYDWEVDEHGGLKPIINPAKVERATKNCANDSFILGTIMSNYNRHKIP---- 83

  Fly   130 GVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRL--SFKGPIK-SLSLSIKMLDKIWRP 191
            |....|:..:.::.:..:|::..|:.:|.|..:.|.|..|  :|..|.| :|||:..:|:|:|.|
 Worm    84 GGQVDVEVEVWVQEITTISDITSDFQLDIYIYETWYDPALNYAFMNPCKYNLSLNSVLLEKLWTP 148

  Fly   192 DTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGY 256
            ::.|.|.|.:.||....||..|.:..||.:..:.||.::..|.|:|..||.|..:|.|...|:.|
 Worm   149 NSCFINSKTADIHKSPFPNIFLMIYANGTVWTNYRLKLQGPCIMDLTKFPFDNVTCSLTFESFNY 213

  Fly   257 INQQLIYEW------KNQDDAVSFVPGMTLNQFDLISMMHRNFTTVRREGDFSVLHVAFNLKRHT 315
            ...::..:|      |.:|.       |.|..::|:.:.....|.....|.:..|.::|..||..
 Worm   214 NTDEVKMDWSVNGVQKMRDK-------MELADYELVDIHKIRTTEEYPAGYWHELTMSFEFKRRA 271

  Fly   316 GYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALD- 379
            |::::|.|:|..|.:.:||:||.:..:|...|..|.|.|:|.::....:...:||:|.|..|:|
 Worm   272 GWYILQAYLPTYLTICISWISFALGSKAIPARTMLGVNSLLAMTFQFGNIIRNLPRVSYVKAIDV 336

  Fly   380 WFL-LMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICI-------------------AN 424
            |.| .|:|::|  :|||.|.|.|.::        .|:.....|:                   ||
 Worm   337 WMLSCMTFVFC--SLLELAWVGYLSR--------EEEPTSAKCLQPSAQVAPKPCHPPPVQQNAN 391

  Fly   425 SLSDHAGEVDGDGEADADPFADEDSSNGSENDDN----------EAGASESVESKSGVCVCNKND 479
            :.|.|        .....|..:|:|:..|..|::          ....:.:::|.|..|.|
 Worm   392 NSSVH--------RRQKQPKNEEESALLSLRDNDYGYIPPGFGLNGNVANAMKSFSSSCSC---- 444

  Fly   480 ALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSD 544
                                           :|:.:: |.|....:|.|.:.|
 Worm   445 -------------------------------EPTNVV-NLMLDEAETIPTSTS------------ 465

  Fly   545 NSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
            :|..:::.|...|.|               ||.|:...||..|...|:.||..|
 Worm   466 SSLSRKQRREILAHK---------------IDSVSVFMFPFLFVLFNIAYWQHY 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	126/548 (23%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	51/190 (27%)
		Cys-loop	233..247	CDD:349808	6/13 (46%)
lgc-46	NP_497338.2	LIC	73..504	CDD:455710	121/522 (23%)
		LGIC_ECD_GABAAR	87..270	CDD:349791	51/189 (27%)
		Cys-loop	190..204	CDD:349791	6/13 (46%)