DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and Glra1

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001277750.1	Gene:	Glra1 / 14654	MGIID:	95747	Length:	457	Species:	Mus musculus

Alignment Length:	537	Identity:	166/537 - (30%)
Similarity:	249/537 - (46%)	Gaps:	117/537 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 YSSSEISNQRRVRRKAAADMLSRNISMILENLLKR---YEQSQLPTHGQGVPTVVQTNILIRSMG 145
            :.|...|.:....|.|...|   :.|..|:.|:.|   |: :::..:.:|.|..|..||.|.|.|
Mouse    17 FFSLAASKEAEAARSAPKPM---SPSDFLDKLMGRTSGYD-ARIRPNFKGPPVNVSCNIFINSFG 77

  Fly   146 PVSELDMDYSMDCYFRQYWRDKRLSF-KGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVP 209
            .::|..|||.::.:.||.|.|.||:: :.|..||.|...|||.||:||.:|.|.|.:..|.||..
Mouse    78 SIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTD 142

  Fly   210 NKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSF 274
            |||||:.:||.:|||:|:|:...|||:|:|||||.|:|.:.:.|:||....||:||:.| .||..
Mouse   143 NKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQ-GAVQV 206

  Fly   275 VPGMTLNQFDLISMMHRNFTTVR-REGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFW 338
            ..|:||.||.|.......:.|.. ..|.|:.:...|:|:|..||:|||:|:|.:|||:|||:|||
Mouse   207 ADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFW 271

  Fly   339 IHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFT 403
            |:.:|...||.|.:|:|||::|.|..||..||||.|..|:|.::.:..|:..:.|||:|.|::.:
Mouse   272 INMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVS 336

  Fly   404 -----------KLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDD 457
                       |....:||.|                            :.|.|::...|..|..
Mouse   337 RQHKELLRFRRKRRHHKSPML----------------------------NLFQDDEGGEGRFNFS 373

  Fly   458 NEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMER 522
            ........:::|.|:.|...|:                                          .
Mouse   374 AYGMGPACLQAKDGISVKGANN------------------------------------------N 396

  Fly   523 TTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSF 587
            .|...|||.|         ||....||                 .::.....||:::||.|||:|
Mouse   397 NTTNPPPAPS---------KSPEEMRK-----------------LFIQRAKKIDKISRIGFPMAF 435

  Fly   588 AFLNLLYWWAYGMYKKE 604
            ...|:.||..|.:.::|
Mouse   436 LIFNMFYWIIYKIVRRE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	162/521 (31%)
		Neur_chan_LBD	111..315	CDD:280998	84/208 (40%)
		Neur_chan_memb	322..>403	CDD:280999	37/80 (46%)
Glra1	NP_001277750.1	LIC	7..446	CDD:273305	164/529 (31%)
		Strychnine-binding. /evidence=ECO:0000250\|UniProtKB:O93430	230..235		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..410		8/69 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810