DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8916 and Gabrd

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_006538609.2	Gene:	Gabrd / 14403	MGIID:	95622	Length:	483	Species:	Mus musculus

Alignment Length:	550	Identity:	149/550 - (27%)
Similarity:	246/550 - (44%)	Gaps:	113/550 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 RSQNATNLSYSSSEISN---------QRRVRRKAAA-----DMLSRNISMI----LENLLKRYEQ 121
            ||::..:||.::..:|.         .|...|:|.|     |.:..|:.:.    |:.|::.|.:
Mouse    23 RSKDPADLSPAARVLSAVLGAERCAVGRDWSRQARAMNDIGDYVGSNLEISWLPNLDGLMEGYAR 87

  Fly   122 SQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLD 186
            :..|..| |.|..|...:.:.|:..:||.:|:|:|..:..|.|||.|||:....::|.|..:.:|
Mouse    88 NFRPGIG-GAPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVD 151

  Fly   187 KIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVI 251
            |:|.|||:..|.|.:..|.:||.|||:||..:|.||||:|:|....|.|:|..:|:|.|.|.|.:
Mouse   152 KLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPLDEQECMLDL 216

  Fly   252 GSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDLISMMHRNFTT----VRREGDFSVLHVAFNLK 312
            .||||.::.::|.|....:.:..:..:.|.||.:.|.   .|||    .:..|.|..|.:.|.|:
Mouse   217 ESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITSY---RFTTELMNFKSAGQFPRLSLHFQLR 278

  Fly   313 RHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATA 377
            |:.|.::||.|:|.:|:|.:|||||||.:.|...||||.:|:|||::|:.:.:|:.||:.....|
Mouse   279 RNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKA 343

  Fly   378 LDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADAD 442
            ||.:..:.:::..|.|:|:|..|:
Mouse   344 LDVYFWICYVFVFAALVEYAFAHF----------------------------------------- 367

  Fly   443 PFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCP 507
                              .|....:.|:.|.|......:.:...:.| .||:.||..:..||...
Mouse   368 ------------------NADYRKKRKAKVKVTKPRAEMDVRNAIVL-FSLSAAGVSQELAISRR 413

  Fly   508 TYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSV 572
            ....|..:                         :.|..|...:.::...::....||....:..:
Mouse   414 QGRVPGNL-------------------------MGSYRSVEVEAKKEGGSRPGGPGGIRSRLKPI 453

  Fly   573 --SLIDRVARIAFPMSFAFLNLLYWWAYGM 600
              ..||..||..||.:||.:|::||.||.|
Mouse   454 DADTIDIYARAVFPAAFAAVNIIYWAAYTM 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	141/520 (27%)
		Neur_chan_LBD	111..315	CDD:280998	73/211 (35%)
		Neur_chan_memb	322..>403	CDD:280999	32/80 (40%)
Gabrd	XP_006538609.2	LGIC_ECD	97..280	CDD:355788	66/185 (36%)
		Cys-loop	198..212	CDD:349787	6/13 (46%)
		LGIC_TM_GABAAR_delta	283..>371	CDD:349857	35/146 (24%)
		TM1 helix	286..306	CDD:349857	12/19 (63%)
		TM2 helix	315..336	CDD:349857	8/20 (40%)
		TM3 helix	346..368	CDD:349857	5/80 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770