DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8916 and Gabrb1

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_032095.1	Gene:	Gabrb1 / 14400	MGIID:	95619	Length:	474	Species:	Mus musculus

Alignment Length:	524	Identity:	170/524 - (32%)
Similarity:	263/524 - (50%)	Gaps:	84/524 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 SYSSSEISNQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPV 147
            ::||:|.||...|:.             .::.|||.|:....|..| |.|..|...|.:.|:..|
Mouse    25 AHSSNEPSNMSYVKE-------------TVDRLLKGYDIRLRPDFG-GPPVDVGMRIDVASIDMV 75

  Fly   148 SELDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKL 212
            ||::|||::..||:|.|:|||||:.|...:|:|..::.|::|.|||||.|.|.|.:|.:||.|::
Mouse    76 SEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRM 140

  Fly   213 LRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPG 277
            :||..:|.:||.:|:|..|.|.|:|:.:|:|.|:|.|.|.||||....:.:.|...:.||:.|..
Mouse   141 IRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNK 205

  Fly   278 MTLNQFDLI--SMMHR--NFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFW 338
            :.|.||.::  .|:.:  .|||    |.:..|.::|.|||:.|||::|.|:|..||.:|||||||
Mouse   206 IELPQFSIVDYKMVSKKVEFTT----GAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFW 266

  Fly   339 IHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFT 403
            |:.:|::.||:|.:|:|||::|||...|..|||:.|..|:|.:|:..|::....|||:|.|:|
Mouse   267 INYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNY-- 329

  Fly   404 KLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVES 468
             :..|:.||                                     ..|:...|..|.....:|
Mouse   330 -IFFGKGPQ-------------------------------------KKGASKQDQSANEKNRLE- 355

  Fly   469 KSGVCVCNK--NDALG--LEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPP 529
                  .||  .||.|  |...:.::|..:|:..|       ...:||...:.:....:.|...|
Mouse   356 ------MNKVQVDAHGNILLSTLEIRNETSGSEVL-------TGVSDPKATMYSYDSASIQYRKP 407

  Fly   530 AVSRLHQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLY 594
            ..|| ......|.......|.|.|..|:|...:......|||   ||:.:|:.||::|:..|::|
Mouse   408 LSSR-EGFGRGLDRHGVPGKGRIRRRASQLKVKIPDLTDVNS---IDKWSRMFFPITFSLFNVVY 468

  Fly   595 WWAY 598
            |..|
Mouse   469 WLYY 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	164/513 (32%)
		Neur_chan_LBD	111..315	CDD:280998	81/207 (39%)
		Neur_chan_memb	322..>403	CDD:280999	38/80 (48%)
Gabrb1	NP_032095.1	LIC	9..472	CDD:273305	169/522 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810