DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8916 and Gabra2

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_032092.1	Gene:	Gabra2 / 14395	MGIID:	95614	Length:	451	Species:	Mus musculus

Alignment Length:	512	Identity:	188/512 - (36%)
Similarity:	263/512 - (51%)	Gaps:	101/512 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 RRVRRKAAADMLSRNISM---ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDY 154
            |.|......|....||::   ||:.||..|:....|..|..: |.|.|||.:.|.||||:.||:|
Mouse    24 RLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSI-TEVFTNIYVTSFGPVSDTDMEY 87

  Fly   155 SMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNG 219
            ::|.:|||.|:|:||.||||:..|.|:..|..|||.|||:|:|||.|..|.:|:||||||:..:|
Mouse    88 TIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDG 152

  Fly   220 GILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWK-NQDDAVSFVP-GMTLNQ 282
            .:||:||||::|.|||.|::||||..||||..|||.|...::.|.|. |..|:|...| |..|||
Mouse   153 TLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQ 217

  Fly   283 FDLISMMHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDR 347
            :||:.......|.....|:::|:...|:|||..|||:||.|:|||:.|:||.||||::||:...|
Mouse   218 YDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 282

  Fly   348 VSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQ 412
            ....||:|||::|:|:.:|..||||.||||:|||:.:.:.:..:.|:|||.|:||||.|..
Mouse   283 TVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWA---- 343

  Fly   413 LEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNK 477
                |:...:.|                     |:....||....|.|
Mouse   344 ----WDGKSVVN---------------------DKKKEKGSVMIQNNA----------------- 366

  Fly   478 NDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYN-DPSYILPNTMERTTQTEPPAVSRLHQMWMCL 541
                   |.|::.|             :.|..: ||  :|....:..|..||.
Mouse   367 -------YAVAVAN-------------YAPNLSKDP--VLSTISKSATTPEPN------------ 397

  Fly   542 KSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
                  :|...:.|.|:|:        .||||.|||::||.||:.|...||:||..|
Mouse   398 ------KKPENKPAEAKKT--------FNSVSKIDRMSRIVFPVLFGTFNLVYWATY 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	187/510 (37%)
		Neur_chan_LBD	111..315	CDD:280998	97/205 (47%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
Gabra2	NP_032092.1	LIC	25..440	CDD:273305	186/509 (37%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	94/202 (47%)
		Cys-loop	166..180	CDD:349836	8/13 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..408		5/36 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4379
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm43906
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3154
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.000