Protein Alignment CG8916 and Gabra1

DIOPT Version :9

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: XP_006532258.1
• Gene: Gabra1 / 14394
• MGIID: 95613
• Length: 553
• Species: Mus musculus
• Alignment Length: 574
• Identity: 194/574 - (33%)
• Similarity: 286/574 - (49%)
• Gaps: 126/574 - (21%)

  Fly    47 ITNEFSSRIFSSFRILPSSKPKTNGSL-----KRSQNATNLSYSSSEISN--QRRVRRKAAADML 104
            :|...|..:||  |:.....|:....|     |:|:..::..::.:.|.:  ..|...:.:.|.|
Mouse    70 LTAILSPTLFS--RVWSDPVPRGGPELCKPVMKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDEL 132

  Fly   105 SRNISM---ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRD 166
            ..|.::   ||:.||..|:....|..|:.| |.|:|:|.:.|.||||:.||:|::|.:|||.|:|
Mouse   133 KDNTTVFTRILDRLLDGYDNRLRPGLGERV-TEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKD 196

  Fly   167 KRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKA 231
            :||.||||:..|.|:..|..|||.|||:|:|||.|..|.:|:||||||:.::|.:||:||||::|
Mouse   197 ERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRA 261

  Fly   232 TCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFV---PGMTLNQFDLISMMHRNF 293
            .|||.|::||||..:|||..|||.|...:::||| .::.|.|.|   .|..|||:||:.....:.
Mouse   262 ECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEW-TREPARSVVVAEDGSRLNQYDLLGQTVDSG 325

  Fly   294 TTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTL 358
            ......|::.|:...|:|||..|||:||.|:|||:.|:||.||||::||:...|....||:|||:
Mouse   326 IVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTM 390

  Fly   359 STISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIA 423
            :|:|:.:|..||||.||||:|||:.:.:.:..:.|:|||.|:||||.|..        |
Mouse   391 TTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYA--------W------ 441

  Fly   424 NSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEYEVS 488
                      ||.......|...:|.
Mouse   442 ----------DGKSVVPEKPKKVKDP--------------------------------------- 457

  Fly   489 LQNSLAGAGFLKRNAIFCPTYNDPSYILPN---------TMERTTQTEPPAVSRLHQMWMCLKSD 544
                     .:|:|..:.||..  || .||         |:.::...||..|
Mouse   458 ---------LIKKNNTYAPTAT--SY-TPNLARGDPGLATIAKSATIEPKEV------------- 497

  Fly   545 NSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
                |...:....:|:        .||||.|||::|||||:.|...||:||..|
Mouse   498 ----KPETKPPEPKKT--------FNSVSKIDRLSRIAFPLLFGIFNLVYWATY 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	183/520 (35%)
		Neur_chan_LBD	111..315	CDD:280998	95/206 (46%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
Gabra1	XP_006532258.1	LIC	105..539	CDD:273305	184/535 (34%)
		LGIC_ECD_GABAAR_A1	153..346	CDD:349835	89/194 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3055
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm43906
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3154
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.950