DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8916 and Gabra4

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_542154.3	Gene:	Gabra4 / 140675	RGDID:	621670	Length:	552	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	189/560 - (33%)
Similarity:	279/560 - (49%)	Gaps:	87/560 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 ATNLSYSSSEISNQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRS 143
            ||.|:.|..:.|...:        :...|.:.||::||..|:....|..| |..|.|:|:|.:.|
  Rat    27 ATCLNESPGQNSKDEK--------LCPENFTRILDSLLDGYDNRLRPGFG-GPVTEVKTDIYVTS 82

  Fly   144 MGPVSELDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITV 208
            .||||:::|:|:||.:|||.|.||||.:.|||:.|.|:..|:.|:|.|||:|.|||.|..|.:|.
  Rat    83 FGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTA 147

  Fly   209 PNKLLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVS 273
            ||||.|:.:||.|||:|||||.|.|||.|.:||||..:|||..|||.|...::||.|....:...
  Rat   148 PNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSV 212

  Fly   274 FVP--GMTLNQFDLISMMHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVS 336
            .||  ..:|.|:|||.....:.|.....|::.|:.|.|:|:|..|||:||.|:|||:.|:||.||
  Rat   213 EVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVS 277

  Fly   337 FWIHREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHY 401
            |||::|:...|....:|:|||::|:|:.:|..||||.||||:|||:.:.|.:..:.|:|||.|:|
  Rat   278 FWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNY 342

  Fly   402 FTKLGSGE--------------SPQLEDQWEDICIAN----------------SLSDHAGEVDGD 436
            ||.:...:              :|.|:::..:..:.|                |.||.....:..
  Rat   343 FTNIQMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVNSRTEVG 407

  Fly   437 GEADADPFADEDSSN-------GSENDDNEAGASESVESKS-GVCVCNKNDALGLEYEVSLQNSL 493
            ..:.....|.|.|..       .|.|..:.|.|:|::.:.: |:.........|......|:::.
  Rat   408 NHSSKTTAAQESSETTPKAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSAS 472

  Fly   494 AGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLKSDNSFRKQRERNAAAQ 558
            |...|..|......|.|...  :|..:   :.|.||                         :|..
  Rat   473 ARPAFGARLGRIKTTVNTTG--VPGNV---SATPPP-------------------------SAPP 507

  Fly   559 KSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
            .|..|        .|.||:.|||.||::|...|::||..|
  Rat   508 PSGSG--------TSKIDKYARILFPVTFGAFNMVYWVVY 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	183/545 (34%)
		Neur_chan_LBD	111..315	CDD:280998	95/205 (46%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
Gabra4	NP_542154.3	LIC	13..539	CDD:273305	188/558 (34%)
		Neur_chan_LBD	49..256	CDD:280998	95/207 (46%)
		Neur_chan_memb	263..536	CDD:280999	80/310 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..436		11/82 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..470		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..513		9/64 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I2964
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm45994
orthoMCL	1	0.900	-	-		OOG6_105663
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.820