Protein Alignment CG8916 and CHRNB3

DIOPT Version :10

• Sequence 1: NP_573090.3
• Gene: CG8916 / 32553
• FlyBaseID: FBgn0030707
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 392
• Identity: 80/392 - (20%)
• Similarity: 156/392 - (39%)
• Gaps: 102/392 - (26%)

  Fly   104 LSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKR 168
            ::.|...:|.:|.:.|::...|.........|...:.|..:..|.|.:...:.:.:.:|.|.|.:
Human    25 IAENEDALLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDHK 89

  Fly   169 LSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRL------------------ 215
            |.                  |.||.|      ..||.|.||::.|.|
Human    90 LR------------------WNPDDY------GGIHSIKVPSESLWLPDIVLFENADGRFEGSLM 130

  Fly   216 -----DQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGY----INQQLIYEWKNQDDA 271
                 ..||.::::...:.|::|.|::..||.|||:|.:..||:.|    ::..||.|  |.|..
Human   131 TKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINE--NVDRK 193

  Fly   272 VSFVPGMTLNQFDLISM--MHRNFTTVRREGDFS--VLHVAFNLKRHTGYFLIQVYVPCILIVVL 332
            ..|..|    ::::::.  |..|    ||:|.:|  .:..:|.|:|...::.:.:.:||:.:..|
Human   194 DFFDNG----EWEILNAKGMKGN----RRDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFL 250

  Fly   333 SWVSFWIHREATSDRVSLCVTSVLTLSTISL--------DSRTDLPKV-KYATALDWFLLMSFLY 388
            :.:.|::..: ..:::||. ||||...|:.|        .|...:|.: :|...:..|:.:|.:.
Human   251 TVLVFYLPSD-EGEKLSLS-TSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIV 313

  Fly   389 CIATLLEFAGVH------------YFTKLGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADA 441
            .:..:    .||            :..:|...:.|:|      :|    :.||........:.::
Human   314 TVFVI----NVHHRSSSTYHPMAPWVKRLFLQKLPKL------LC----MKDHVDRYSSPEKEES 364

  Fly   442 DP 443
            .|
Human   365 QP 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:455710	80/392 (20%)
		LGIC_ECD_GABAR_GRD-like	132..314	CDD:349808	48/212 (23%)
		Cys-loop	233..247	CDD:349808	7/13 (54%)
CHRNB3	NP_000740.1	LIC	23..449	CDD:455710	80/392 (20%)