DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and gabrg3

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_002931686.2	Gene:	gabrg3 / 100494037	XenbaseID:	XB-GENE-6041774	Length:	446	Species:	Xenopus tropicalis

Alignment Length:	512	Identity:	169/512 - (33%)
Similarity:	253/512 - (49%)	Gaps:	105/512 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 NQRRVRRKAAADMLSRNISMILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYS 155
            ||:.|......|   .:.::||..|||.|::...|..|. .|||:..:|.:.|:||||.::|:|.
Frog    33 NQKWVLAPKTQD---TDATLILNKLLKEYDKKLRPDIGI-KPTVIDVDIYVNSIGPVSSINMEYQ 93

  Fly   156 MDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGG 220
            :|.:|.|.|.|.||.|...:|.|:|:..|:..||.|||.|.|.|.::.|.||.||:|||:..:|.
Frog    94 IDIFFAQTWTDSRLRFNSTMKILTLNSNMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGK 158

  Fly   221 ILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDL 285
            |||::||||.|.|.::|.|||||..||||:..||||..::::|.|:......:......|.|||.
Frog   159 ILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYGYPREEMVYRWRKNSVETANQKSWRLYQFDF 223

  Fly   286 ISMMHRNFTTVRR--EGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRV 348
            :.:  ||.|.:.:  .||:.|:.|.|:|.|..|||.||.|:||||.||||||||||.::||..|.
Frog   224 MGL--RNTTEIVKTSAGDYIVMTVYFDLSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPART 286

  Fly   349 SLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQL 413
            :|.:|:|||::|:|..:|..||:|.|.||:|.|:.:.||:..|.|:|:|.::|::   |.:.|:
Frog   287 ALGITTVLTMTTLSTIARKSLPRVSYVTAMDLFVTVCFLFVFAALIEYAALNYYS---SCKKPR- 347

  Fly   414 EDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGS--ENDDNEAGASESVESKSGVCVCN 476
                   |.....|:::       ..|..|.....:.|.|  ..:..||...|.::.|.    |
Frog   348 -------CTKKKKSNYS-------VLDMRPPPTVITLNNSLYWQEFEEACVYECLDGKD----C- 393

  Fly   477 KNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCL 541
                                     .:.|| .|::                            |
Frog   394 -------------------------QSFFC-CYDE----------------------------C- 403

  Fly   542 KSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
             ...|:|:.|               .:::.:.| |..:|:.||.||...||:||..|
Frog   404 -KSGSWRRGR---------------IHIDLLEL-DSYSRVFFPTSFLLFNLVYWVGY 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	167/509 (33%)
		Neur_chan_LBD	111..315	CDD:280998	87/205 (42%)
		Neur_chan_memb	322..>403	CDD:280999	41/80 (51%)
gabrg3	XP_002931686.2	Neur_chan_LBD	47..253	CDD:280998	87/208 (42%)
		LIC	50..443	CDD:273305	164/490 (33%)
		Neur_chan_memb	260..440	CDD:280999	70/274 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	203	1.000	Domainoid score	I2891
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm49077
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.020