DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and gabra2a

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	XP_009305482.1	Gene:	gabra2a / 100150704	ZFINID:	ZDB-GENE-141216-16	Length:	451	Species:	Danio rerio

Alignment Length:	519	Identity:	186/519 - (35%)
Similarity:	267/519 - (51%)	Gaps:	111/519 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 SSSEISNQRRVRRKAAADMLSRNISM---ILENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGP 146
            |.:|:|         .:|....||::   ||:.||..|:....|..|..| |.|:|:|.:.|.||
Zfish    25 SEAEVS---------GSDAFKNNITLFTRILDRLLDGYDNRLRPGLGDRV-TEVKTDIYVTSFGP 79

  Fly   147 VSELDMDYSMDCYFRQYWRDKRLSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNK 211
            ||:.||:|::|.:|||.|.|:||.|.||:..|.|:..|..|||.|||:|:|||.|..|.:|:|||
Zfish    80 VSDTDMEYTVDVFFRQRWTDERLKFHGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNK 144

  Fly   212 LLRLDQNGGILYSMRLTIKATCPMELQNFPMDRQSCPLVIGSYGYINQQLIYEW-KNQDDAVSFV 275
            |||:.:||.:||:||||::|.|||.|::||||..||||..|||.|...::.|.| :|...:|...
Zfish   145 LLRIMENGTLLYTMRLTVQAECPMHLEDFPMDFHSCPLKFGSYAYTLTEVTYVWTRNATLSVEVA 209

  Fly   276 P-GMTLNQFDLISMMHRNFTTVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWI 339
            | |..|||:||:.......|.....|:::|:...|:|||..|||:||.|:|||:.|:||.||||:
Zfish   210 PDGSRLNQYDLMGQTVGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWL 274

  Fly   340 HREATSDRVSLCVTSVLTLSTISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTK 404
            :||:...|....||:|||::|:|:.:|..||||.||||:|||:.:.:.:..:.|:|||.|:||||
Zfish   275 NRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTK 339

  Fly   405 LGSGESPQLEDQWEDICIANSLSDHAGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESK 469
            .|..        |:...|.|                                          :.|
Zfish   340 RGWA--------WDGKSIVN------------------------------------------DKK 354

  Fly   470 SGVCVCNKNDALGLEYEVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRL 534
            ....|..||:|    |.|::.|             :.|.....| .|| |:.::...||
Zfish   355 KETSVMKKNNA----YAVAVAN-------------YAPHIAKDS-ALP-TVSKSATPEP------ 394

  Fly   535 HQMWMCLKSDNSFRKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
                            .:....|:::::     ..||||.|||::||.||:.|...||:||..|
Zfish   395 ----------------SKAQPVAKETKK-----TFNSVSKIDRMSRIIFPVLFGSFNLVYWATY 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	182/510 (36%)
		Neur_chan_LBD	111..315	CDD:280998	96/205 (47%)
		Neur_chan_memb	322..>403	CDD:280999	39/80 (49%)
gabra2a	XP_009305482.1	LIC	17..437	CDD:273305	185/517 (36%)
		Neur_chan_LBD	43..250	CDD:280998	96/207 (46%)
		Neur_chan_memb	257..434	CDD:280999	76/272 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3005
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2100
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1057372at2759
OrthoFinder	1	1.000	-	-		FOG0000415
OrthoInspector	1	1.000	-	-		otm24219
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X127
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970