DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8916 and gabrb3

DIOPT Version :9

Sequence 1:	NP_573090.3	Gene:	CG8916 / 32553	FlyBaseID:	FBgn0030707	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001096164.1	Gene:	gabrb3 / 100124708	XenbaseID:	XB-GENE-6030743	Length:	475	Species:	Xenopus tropicalis

Alignment Length:	506	Identity:	170/506 - (33%)
Similarity:	263/506 - (51%)	Gaps:	79/506 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 NISMI---LENLLKRYEQSQLPTHGQGVPTVVQTNILIRSMGPVSELDMDYSMDCYFRQYWRDKR 168
            |:|.:   ::.|||.|:....|..| |.|..|..||.|.|:..|||::|||::..||:|||||||
Frog    33 NMSFVKETVDKLLKGYDIRLRPDFG-GSPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKR 96

  Fly   169 LSFKGPIKSLSLSIKMLDKIWRPDTYFYNGKHSQIHMITVPNKLLRLDQNGGILYSMRLTIKATC 233
            |::.|...:|:|..::.|::|.|||||.|.|.|.:|.:||.|:::||..:|.:||.:|:|..|.|
Frog    97 LAYTGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAAC 161

  Fly   234 PMELQNFPMDRQSCPLVIGSYGYINQQLIYEWKNQDDAVSFVPGMTLNQFDLI--SMMHRN--FT 294
            .|:|:.:|:|.|:|.|.|.||||....:.:.|...|:||:.|..:.|.||.::  .::.:|  |.
Frog   162 MMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWLGGDNAVTGVERIELPQFSIMDHKLVSKNVVFA 226

  Fly   295 TVRREGDFSVLHVAFNLKRHTGYFLIQVYVPCILIVVLSWVSFWIHREATSDRVSLCVTSVLTLS 359
            |    |.:..|.::|.|||:.|||::|.|:|.|||.:||||||||:.:|::.||:|.:|:|||::
Frog   227 T----GSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMT 287

  Fly   360 TISLDSRTDLPKVKYATALDWFLLMSFLYCIATLLEFAGVHYFTKLGSGESPQLEDQWEDICIAN 424
            ||:...|..|||:.|..|:|.:|:..|::....|||:|.|:|   :..|..||::.:..:.. |.
Frog   288 TINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNY---IFFGRGPQMQKKLAEKS-AK 348

  Fly   425 SLSDH----AGEVDGDGEADADPFADEDSSNGSENDDNEAGASESVESKSGVCVCNKNDALGLEY 485
            |..||    :..||..|..........:...|:|...:.:.|..|..|         .|..|::|
Frog   349 SNKDHSKFESNRVDAHGNILLTTLEIHNEVTGNEITTSVSDARNSATS---------FDNSGIQY 404

  Fly   486 EVSLQNSLAGAGFLKRNAIFCPTYNDPSYILPNTMERTTQTEPPAVSRLHQMWMCLK---SDNSF 547
            .   :.|.|.....:|.|                    .:..||..:.|.:....||   .|
Frog   405 R---KQSTARDSLGRRTA--------------------DRNHPPKKTHLRRRSSQLKIKIPD--- 443

  Fly   548 RKQRERNAAAQKSEQGGANCYVNSVSLIDRVARIAFPMSFAFLNLLYWWAY 598
                                 :..|:.|||.:||.||::|:..||:||..|
Frog   444 ---------------------LTDVNAIDRWSRIVFPITFSLFNLIYWLYY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8916	NP_573090.3	LIC	92..598	CDD:273305	169/504 (34%)
		Neur_chan_LBD	111..315	CDD:280998	84/210 (40%)
		Neur_chan_memb	322..>403	CDD:280999	38/80 (48%)
gabrb3	NP_001096164.1	LIC	11..473	CDD:273305	169/504 (34%)
		Neur_chan_LBD	41..243	CDD:280998	84/206 (41%)
		Neur_chan_memb	250..470	CDD:280999	77/279 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910