DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrp4 and DGCR2

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_005128.1	Gene:	DGCR2 / 9993	HGNCID:	2845	Length:	550	Species:	Homo sapiens

Alignment Length:	456	Identity:	84/456 - (18%)
Similarity:	136/456 - (29%)	Gaps:	170/456 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 CTDDQFECLNGF--CIPRTWVCDGENDCKDFSDETHCNRTT----------CTD----------- 308
            |...||.|.:|.  |||..|.|||...|:|.|||.:|...|          ..|
Human    30 CNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVTGEVRPHHGKEAVDPRQGRARGGDP 94

  Fly   309 EHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRF 373
            .||     :.:::|             ..::.::.:..||.|.....|        :..|.  |.
Human    95 SHF-----HAVNVA-------------QPVRFSSFLGKCPTGWHHYEG--------TASCY--RV 131

  Fly   374 RCDGDNDCGDWSDEENCPQ----KPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSL 434
            ...|:|   .|...:.|.:    ..:..|..|.:..    :.:.|  |:.:...|.:|:.... :
Human   132 YLSGEN---YWDAAQTCQRLNGSLATFSTDQELRFV----LAQEW--DQPERSFGWKDQRKLW-V 186

  Fly   435 GSEHPLTCGSDEFTCNNGRCILKTW--LCDG-----------YPDCAAGEDEVEC-HLQC----- 480
            |.::.:|        ...|.:...|  ...|           :....:..|.|.| .|||
Human   187 GYQYVIT--------GRNRSLEGRWEVAFKGSSEVFLPPDPIFASAMSENDNVFCAQLQCFHFPT 243

  Fly   481 ----DL-----------GQFLCPTKQNLTNLKICVHQKHICDGHNECPAGED----------EAD 520
                ||           ..|||...|...::|..|    :.:|....|.|:|          |.:
Human   244 LRHHDLHSWHAESCYEKSSFLCKRSQTCVDIKDNV----VDEGFYFTPKGDDPCLSCTCHGGEPE 304

  Fly   521 CPKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMG 585
            ......|..|..|:|.    .....||.          |..|.|.|          .....::|.
Human   305 MCVAALCERPQGCQQY----RKDPKECC----------KFMCLDPD----------GNSLFDSMA 345

  Fly   586 S---FKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFH 647
            |   ...||.:.:::.           ::.|.:.:|...||           .:.:.:.|..:.|
Human   346 SGMRLVVSCISSFLIL-----------SLLLFMVHRLRQRR-----------RERIESLIGANLH 388

  Fly   648 H 648
            |
Human   389 H 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	17/35 (49%)
		LDLa	306..340	CDD:238060	4/44 (9%)
		LDLa	347..390	CDD:238060	9/42 (21%)
		LDLa	397..431	CDD:238060	6/33 (18%)
		LDLa	442..476	CDD:238060	5/46 (11%)
		LDLa	480..521	CDD:238060	14/70 (20%)
		FXa_inhibition	576..604	CDD:291342	4/30 (13%)
		LY	634..671	CDD:214531	3/15 (20%)
		NHL	<656..793	CDD:302697
		LY	680..714	CDD:214531
		NHL repeat	681..722	CDD:271320
		NHL repeat	726..760	CDD:271320
		LY	761..803	CDD:214531
		NHL repeat	769..793	CDD:271320
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
DGCR2	NP_005128.1	LDLa	30..66	CDD:238060	17/35 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..92		2/22 (9%)
		CLECT_DGCR2_like	115..267	CDD:153069	32/179 (18%)
		VWC	271..329	CDD:214564	13/75 (17%)
		Atrophin-1	<428..537	CDD:331285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900