DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and Lrp1b

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_006498522.1 Gene:Lrp1b / 94217 MGIID:2151136 Length:4668 Species:Mus musculus


Alignment Length:1845 Identity:592/1845 - (32%)
Similarity:915/1845 - (49%) Gaps:271/1845 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   192 QPGETYSNCQNSN--------ESDENC--NPEEDAV-------PNLQRDCEKTGIHVMCPRTFRC 239
            :|||  ..|:|.:        :.|::|  ..:||:|       |:.|..|:..          ||
Mouse   877 KPGE--FRCKNKHCIQARWKCDGDDDCLDGSDEDSVTCFNHSCPDDQFKCQNN----------RC 929

  Fly   240 ISKYWLCDGDDDCGDYSDETH--CGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDE-THC 301
            |.|.|||||.:|||...||::  |.||| |..|||.|.||.|||..|:||.|:||.|.:|| ..|
Mouse   930 IPKRWLCDGANDCGSNEDESNQTCTART-CQADQFSCGNGRCIPTAWLCDREDDCGDQTDEVASC 993

  Fly   302 NRTTCTD-EHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPS 365
            ...||.. ..|.|..|.|||..:.||.:.||.|.|||:.|   ::||.:.:|:|         .|
Mouse   994 EFPTCEPLTQFICKSGRCISNKWHCDTDDDCGDRSDEVGC---VHSCLDDQFRC---------SS 1046

  Fly   366 GQCILNRFRCDGDNDCGDWSDEE--NCPQK----PSLCTSNEYKC-ADGTCIPKRWKCDKEQDCD 423
            |:||...:.|||||||||:|||.  ||.::    |:.|..||::| .||.|||..|:||.|:||:
Mouse  1047 GRCIPGHWACDGDNDCGDFSDETHINCTKEEARSPAGCIGNEFQCRPDGNCIPDLWRCDGEKDCE 1111

  Fly   424 GGEDENDC-GSLG-SEHPLTCGSDEFTC-NNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQF 485
            .|.||..| |::. .:|     ..:|:| :.||||...|:|||..||....||.:|      ..|
Mouse  1112 DGSDEKGCNGTIRLCDH-----KTKFSCRSTGRCINNAWVCDGDVDCEDQSDEEDC------DSF 1165

  Fly   486 LC-PTKQNLTN-LKICVHQKHICDGHNECPAGEDEADCPKERKCS-EPSPCEQLCIETTAGSNEC 547
            || |.|....| ..:|:..:.:|:|..:||.|.||.|...|  || ....|...|.........|
Mouse  1166 LCGPPKYPCANDTSVCLQPEKLCNGRKDCPDGSDEGDLCDE--CSLNNGGCSNHCSVVPGRGIVC 1228

  Fly   548 ACRLGYVMDKNKVNCTDIDEC-QYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAM 611
            :|..|:.:.|:...|..:|.| .:|.   |||.|.......||||..|:.|..|..||.::....
Mouse  1229 SCPEGHQLKKDNRTCEIVDYCASHLR---CSQVCEQQKHMVKCSCYEGWALGTDGESCTSVDSFE 1290

  Fly   612 TLLVAN-RWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVI---KMVYMNG-T 671
            ..::.: |.:|||:.|....||.:|.||.|.||||||..:.|::|:||..|.|   |:....| :
Mouse  1291 AFIIFSIRHEIRRIDLHKGDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVS 1355

  Fly   672 RVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGE 736
            .:..|::.||.:|.|:.||||...::|.||...::|||...|:||..:.:..::.||||.:.|..
Mouse  1356 AIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGSLRATLIAGAMEHPRAIALDPRY 1420

  Fly   737 ALAFWSDWGPN-PKIERAYMDGTQRKVIIS--KGVTWPNGLAIDFPNSKIYWADAKQHAIECSNL 798
            .:.||:||..| |:||.|.|.|..||.|..  |...|||||.:|....:|.|.||:..||..:..
Mouse  1421 GILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFERRIVWTDARSDAIYSAFY 1485

  Fly   799 DGSDRNKILSTH--LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAY 861
            ||::..:|:..|  |.||||::|:...:|||||.|.|::.|:|.||:....:.:....|.|:..|
Mouse  1486 DGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLAKANKWTGQNVSVIQKTSAQPFDLQIY 1550

  Fly   862 HPARQPEYADRCQKDRRGLRGGCSHLCLPN-KTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARR 925
            ||:|||:..:.|..:..  ||.||||||.| ..|..|.||..:.|..|.|||.. ..|.:|.|||
Mouse  1551 HPSRQPQAPNPCAANEG--RGPCSHLCLINHNRSAACACPHLMKLSSDKKTCYE-MKKFLLYARR 1612

  Fly   926 KDIRLRHLRDNQADPNDVDMIVPLDN---------LKHAVALDWCSDTDFIYWTDVERSTINKAH 981
            .:||            .||:..|..|         :.....:|:.:..:.:||||::..||.:|.
Mouse  1613 SEIR------------GVDIDNPYVNFITAFTVPDIDDVAVIDFDASEERLYWTDIKTQTITRAF 1665

  Fly   982 LNGSYQQRVVHSNLVSPVGLALDWITDKLYW--TDPSTNRIEVATTNGKMRTLLIWEKLYKPRDI 1044
            :||:..:.|:..::.|..|||:||::..|||  ::....:|.||..:|.::|.:| ..:.||:.:
Mouse  1666 INGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCL 1729

  Fly  1045 VVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPN-----GLAIDYEKSKIYFVDGGT 1104
            ..:|:.|.::|:|..   .|..|||||      ::.|:::.|     ||:|||.::|:|::..|.
Mouse  1730 AAHPVRGKLYWTDGN---TINMANMDG------SNSKILFQNQKEPVGLSIDYVENKLYWISSGN 1785

  Fly  1105 KTLENMNFDGSGRQVI---LNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANST 1166
            .|:...|.||...:||   ...|.....|.:.:.:::|.|.:...:.:.||..|::.:::...::
Mouse  1786 GTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCNKRDGRNPSILRNKTS 1850

  Fly  1167 DLMDIRVFHRTRRRIFNACDKLNGGCSHLCL-LNPTSYTCACTVGVQLKEDRHTCSEGPTQYILF 1230
            .::.::|:.:..::..|:|...|||||.||| .:.|:.||.||||..|:::|.:| :|...::::
Mouse  1851 GVVHMKVYDKEAQQGSNSCQVNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSC-QGIESFLMY 1914

  Fly  1231 AHRIDIRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIV 1295
            :....||.|.|:....:|.::|:...:.||.:|...:...|||:|...|.|..:..|....:.:|
Mouse  1915 SVHEGIRGIPLEPRDKVDALMPISGAAFAVGIDFHAENDTIYWTDMGLNKISRAKRDQTWKEDVV 1979

  Fly  1296 GDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWT 1360
            .:.|...:|:.||.|...|||.|.|.:.||||.|:||.|:||..:.|:.||.:|:..|.|.||||
Mouse  1980 TNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGFLFWT 2044

  Fly  1361 DWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDY-TGNQRKLI 1424
            :||....|.::.|||:|:..||:..:.||||:|:|.:..::||.|||...|:..|. ||..|:::
Mouse  2045 EWGQVPCIGKARLDGSEKVMIVSVGITWPNGISIDYEENKLYWCDARSDKIERIDLDTGANREVL 2109

  Fly  1425 MSSLH-HPYALALSDDNIYWTDWKSKALHMTERRNISAKRDIITNIDG----LMDIKIIYQNQNQ 1484
            :|..: ..:::|:....|||:| ::.|.....|.:.:...:.:|...|    |.:|||..:.:.:
Mouse  2110 LSGSNVDLFSVAVFGAYIYWSD-RAHANGSVRRGHKNDATETVTMRTGLGVNLKEIKIFNRVREK 2173

  Fly  1485 STMKNACGNNNGNCSHLCL-RNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISL 1548
            .|  |.|...||.|..||| |..|..:|.|..|. |..:..|..::  |.|||.:.|:.:..|.|
Mouse  2174 GT--NVCAKENGGCQQLCLYRGNSRRTCACAHGY-LAGDGVTCLRH--EGYLLYSGRTILKSIHL 2233

  Fly  1549 --------------NSGDFMDVVLPINGVHGAVVLDYHYRK---NLLFFADV---NLDVIRRVNL 1593
                          |...|.:::        |:..||:.|:   |.:|::|.   |:.:|:.   
Mouse  2234 SDETNLNSPVRPYENPNYFKNII--------ALAFDYNQRREGTNRIFYSDAHFGNIQLIKD--- 2287

  Fly  1594 LNLTESKVIVGTDVLTPNGIAVDWIADNLYW-----SDTDRKLIEVSRLDGSCRKRIV---EDNL 1650
             |..:.:||| .:|.:..|:|.....|.|||     |...|..::.:|.....|:.::   ||: 
Mouse  2288 -NWEDRQVIV-ENVGSVEGLAYHRAWDTLYWTSSSTSSITRHTVDQTRPGAIDREAVITMSEDD- 2349

  Fly  1651 GDPRSLIVHPKKAYLFWSDWSSP-AKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADA 1714
             .|..|.:...:..:||::|:.. ..|.|:.|.|.|..|::::.|..|.|||||....:|.::|.
Mouse  2350 -HPHVLALDECQNLMFWTNWNEQHPSIMRATLTGKNAHVVVSTDILTPNGLTIDHRAEKLYFSDG 2413

  Fly  1715 LEDNIGQVDFNGKRRQTIVPYAPHPF-GLTLFENSIFWTDWYNKSVYRSQ-------KLARSGYG 1771
            ....|.:.:::|.:|..||...|..| .|.::::.|||:||..:::.||.       |:.||.. 
Mouse  2414 SLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDSYIFWSDWGRRAILRSNKYTGGETKILRSDI- 2477

  Fly  1772 NPFEVRDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTHLCL--------------------NR- 1815
             |.:....::.|.|..:..||       .||..||||..|||                    || 
Mouse  2478 -PHQPMGIIAVANDTNSCELS-------PCALLNGGCHDLCLLTPDGRVNCSCRGDRVLLANNRC 2534

  Fly  1816 -------------------NVDYVCACPDVMDPKDVACSIKPKVLVHANLENDQLLEYSDESTDD 1861
                               .||||..|..:...||.:              :::||...:.|...
Mouse  2535 VTKNSSCNIYSEFECGNGDCVDYVLTCDGIPHCKDKS--------------DEKLLYCENRSCRS 2585

  Fly  1862 STPP----------ELLGESNDHGD 1876
            ...|          :|...:||.||
Mouse  2586 GFKPCYNRRCVPHGKLCDGTNDCGD 2610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 19/34 (56%)
LDLa 306..340 CDD:238060 15/34 (44%)
LDLa 347..390 CDD:238060 19/44 (43%)
LDLa 397..431 CDD:238060 18/34 (53%)
LDLa 442..476 CDD:238060 14/34 (41%)
LDLa 480..521 CDD:238060 14/42 (33%)
FXa_inhibition 576..604 CDD:291342 11/27 (41%)
LY 634..671 CDD:214531 18/40 (45%)
NHL <656..793 CDD:302697 54/143 (38%)
LY 680..714 CDD:214531 14/33 (42%)
NHL repeat 681..722 CDD:271320 16/40 (40%)
NHL repeat 726..760 CDD:271320 16/34 (47%)
LY 761..803 CDD:214531 17/43 (40%)
NHL repeat 769..793 CDD:271320 10/23 (43%)
FXa_inhibition 882..912 CDD:291342 15/30 (50%)
LY 946..985 CDD:214531 11/47 (23%)
NHL <967..1142 CDD:302697 56/184 (30%)
LY 988..1030 CDD:214531 14/43 (33%)
NHL repeat 998..1037 CDD:271320 14/40 (35%)
NHL repeat 1038..1080 CDD:271320 12/41 (29%)
NHL repeat 1084..1119 CDD:271320 13/39 (33%)
FXa_inhibition 1185..1220 CDD:291342 18/35 (51%)
NHL 1260..>1445 CDD:302697 70/186 (38%)
NHL repeat 1260..1296 CDD:271320 9/35 (26%)
NHL repeat 1302..1337 CDD:271320 17/34 (50%)
NHL repeat 1345..1383 CDD:271320 17/37 (46%)
FXa_inhibition <1499..1525 CDD:291342 9/26 (35%)
LY 1600..1640 CDD:214531 13/44 (30%)
LY 1643..1686 CDD:214531 11/46 (24%)
LY 1688..1729 CDD:214531 12/40 (30%)
FXa_inhibition 1801..>1825 CDD:291342 16/63 (25%)
Lrp1bXP_006498522.1 LDLa 1167..1202 CDD:238060 12/34 (35%)
FXa_inhibition 1207..1243 CDD:373209 8/35 (23%)
LY 1311..1352 CDD:214531 19/40 (48%)
LY 1358..1398 CDD:214531 15/39 (38%)
LY 1402..1445 CDD:214531 16/42 (38%)
LY <1457..1489 CDD:214531 14/31 (45%)
LY 1635..1670 CDD:214531 10/34 (29%)
LY 1672..1714 CDD:214531 13/41 (32%)
LY 1716..1755 CDD:214531 14/48 (29%)
LY <1766..1797 CDD:214531 12/30 (40%)
FXa_inhibition 1869..1905 CDD:373209 18/35 (51%)
NHL 1944..2169 CDD:302697 79/225 (35%)
NHL repeat 1944..1983 CDD:271320 10/38 (26%)
LY 1978..2018 CDD:214531 18/39 (46%)
NHL repeat 1988..2025 CDD:271320 19/36 (53%)
NHL repeat 2029..2070 CDD:271320 18/40 (45%)
Ldl_recept_b 2039..2079 CDD:278487 19/39 (49%)
LY 2064..2106 CDD:214531 17/41 (41%)
NHL repeat 2073..2111 CDD:271320 15/37 (41%)
NHL repeat 2120..2159 CDD:271320 9/39 (23%)
FXa_inhibition 2178..2213 CDD:373209 13/35 (37%)
Ldl_recept_b 2361..2402 CDD:278487 14/40 (35%)
LY 2386..2428 CDD:214531 12/41 (29%)
LDLa 2545..2574 CDD:238060 7/42 (17%)
LDLa 2583..2617 CDD:238060 6/28 (21%)
LDLa 2622..2656 CDD:238060
LDLa 2676..2705 CDD:238060
LDLa 2713..2747 CDD:238060
LDLa 2751..2784 CDD:238060
LDLa 2791..2824 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2922..2956 CDD:238060
LDLa 63..95 CDD:238060
LDLa 107..140 CDD:197566
FXa_inhibition 194..224 CDD:373209
LY 314..346 CDD:214531
LY 350..392 CDD:214531
LY 394..435 CDD:214531
FXa_inhibition 514..547 CDD:373209
LY 580..621 CDD:214531
LY 622..661 CDD:214531
LY 668..717 CDD:214531
LY 718..760 CDD:214531
FXa_inhibition 829..864 CDD:373209
LDLa 917..950 CDD:238060 17/42 (40%)
LDLa 957..989 CDD:197566 18/32 (56%)
LDLa 1000..1033 CDD:238060 14/32 (44%)
LDLa 1037..1070 CDD:238060 19/41 (46%)
LDLa 1084..1119 CDD:238060 18/34 (53%)
Ldl_recept_a 1131..1162 CDD:365841 14/30 (47%)
cEGF 2979..3002 CDD:372248
EGF_CA 2999..3033 CDD:214542
LY 3066..3110 CDD:214531
LY 3111..3149 CDD:214531
LY 3154..3195 CDD:214531
LY 3198..3237 CDD:214531
FXa_inhibition 3308..3344 CDD:373209
LDLa 3348..3379 CDD:197566
LDLa 3388..3422 CDD:238060
LDLa 3427..3462 CDD:238060
LDLa 3467..3502 CDD:238060
LDLa 3507..3541 CDD:238060
LDLa 3546..3580 CDD:238060
LDLa 3584..3618 CDD:238060
LDLa 3625..3659 CDD:238060
LDLa 3663..3698 CDD:238060
LDLa 3705..3737 CDD:238060
LDLa 3746..3782 CDD:238060
LDLa 3793..3827 CDD:238060
EGF_CA 3875..3909 CDD:214542
NHL 3972..4204 CDD:302697
NHL repeat 4002..4039 CDD:271320
NHL repeat 4060..4098 CDD:271320
Ldl_recept_b 4070..4110 CDD:393440
LY 4094..4133 CDD:214531
NHL repeat 4148..4186 CDD:271320
EGF_CA 4281..4315 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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