DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and Lrp4

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_112612.2 Gene:Lrp4 / 83469 RGDID:619731 Length:1905 Species:Rattus norvegicus


Alignment Length:1812 Identity:776/1812 - (42%)
Similarity:1082/1812 - (59%) Gaps:118/1812 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   200 CQNSNESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHCGAR 264
            |...|:..::.:.:...:|.    |.....|  |... :||.:.|:||||:||.|.|||..|..|
  Rat    51 CDGDNDCGDHSDEDGCTLPT----CSPLDFH--CDNG-KCIRRSWVCDGDNDCEDDSDEQDCPPR 108

  Fly   265 TNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEH 329
             .|.:|:|.|.||:||...|.|||:|||.|.||| .|:...|:|:.|.|:||.||:..:.|||:.
  Rat   109 -ECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE-QCDMRKCSDKEFRCSDGSCIAEHWYCDGDT 171

  Fly   330 DCNDNSDELKCAAVINS--CPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENC-P 391
            ||.|.|||..|.:.:.|  |...||:|         ..|:.||:.:.||||:||||||||.:| .
  Rat   172 DCKDGSDEESCPSAVPSPPCNLEEFQC---------AYGRRILDIYHCDGDDDCGDWSDESDCSS 227

  Fly   392 QKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCIL 456
            .:|  |.|.|:.|..|.|:...|:||.:.|||...||.:|.:      ..|.:::|.|.:|||:.
  Rat   228 HQP--CRSGEFMCDSGLCVNAGWRCDGDADCDDQSDERNCTT------SMCTAEQFRCRSGRCVR 284

  Fly   457 KTWLCDGYPDCAAGEDEVECH----LQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGED 517
            .:|.|||..|||...||..|.    .||...||||...:       |:.|:.:|:|.|:|....|
  Rat   285 LSWRCDGEDDCADNSDEENCENTGSPQCASDQFLCWNGR-------CIGQRKLCNGVNDCGDNSD 342

  Fly   518 EA---DC-PK--ERKCS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPV 575
            |:   :| |:  |..|: ....|.|.| :...|:.:|.|..||.:.::...|.|::||  .....
  Rat   343 ESPQQNCRPRTGEENCNVNNGGCAQKC-QMIRGAVQCTCHTGYRLTEDGRTCQDVNEC--AEEGY 404

  Fly   576 CSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHN 640
            |||.|.|:.|:|:|.||.||.||||.|||||||....||.|||.|||:|....:.|:.::..|.|
  Rat   405 CSQGCTNSEGAFQCWCEAGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLEN 469

  Fly   641 AIALDFHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRR 705
            |||||||||:.|:|||||:.|.|....:||:.|.:|:..|||||||:||||:||.|:||||||.|
  Rat   470 AIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSR 534

  Fly   706 VEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTW 770
            :||:|..|..|.|:....|:|||||.:||.|...:|:|||..|:||.:.|||:.|::|....:.|
  Rat   535 IEVANLDGAHRKVLLWQSLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFW 599

  Fly   771 PNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVS 835
            ||||.||:...::||.|||.|.||.:|||||.|..::|..||||||:|:|||::|||||:||:::
  Rat   600 PNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSIN 664

  Fly   836 AADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPNKTSRRCGCP 900
            :|:|.|||....:....|||||||..||.|||...:||..:    .|||:|||||:..:..|.||
  Rat   665 SANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDN----NGGCTHLCLPSGQNYTCACP 725

  Fly   901 IGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDV-DMIVPLDNLKHAVALDWCSDT 964
            .|.. |.:...|..:.||.:|.|||.|||....     |..|: |.::||.:::.||||||.|..
  Rat   726 TGFR-KINSHACAQSLDKFLLFARRMDIRRISF-----DTEDLSDDVIPLADVRSAVALDWDSRD 784

  Fly   965 DFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKM 1029
            |.:|||||...||::|..:|:.|:.||.::|.||.|||:||:|:||||||..|:|||||.|:|.|
  Rat   785 DHVYWTDVSTDTISRAKWDGTGQKVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSM 849

  Fly  1030 RTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEK 1094
            ||:||||.|.:||||||.|:.|:|:|:|||..|.||||.||...|..|.|..|.:||||||||..
  Rat   850 RTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASNRQVIISSNLTWPNGLAIDYGS 914

  Fly  1095 SKIYFVDGGTKTLENMNFDGSGRQVILNG-LGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDT 1158
            .::|:.|.|.||:|....|||.|:|::.. |.|||||.:...|::||||.|||:.||::|||.|.
  Rat   915 QRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSADRLTGLDR 979

  Fly  1159 NVIIANSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLL--NPTSYTCACTVGVQLKEDRHTCS 1221
            ..:..|..:||||.||||.|..:...|...|||||||||.  :|:.::|.|..|:.|..|..|||
  Rat   980 ETLQENLENLMDIHVFHRQRPPVTTPCAVENGGCSHLCLRSPSPSGFSCTCPTGINLLLDGKTCS 1044

  Fly  1222 EGPTQYILFAHRIDIRQISLDFDHLIDVVLPL-PPISNAVALDVDRKTGYIYWSDTIENVIMSSS 1285
            .|...:::||.|||:|.:|||..:..|||:|: ..:.|.:|:.||...|.:||||:..:.|..:|
  Rat  1045 PGMNSFLIFARRIDVRMVSLDIPYFADVVVPINMTMKNTIAIGVDPLEGKVYWSDSTLHRISRAS 1109

  Fly  1286 PDGLHVQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLAL 1350
            .||...:.|:...|:..|||.||:|||.:||.|.|.:.|||.:||||.|.|:.:::|:|||.:.|
  Rat  1110 LDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVL 1174

  Fly  1351 DYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCD 1415
            .:|.|.::|||||...|:|||.:||::|:.::..||||||||::|..|.::.|.||..:.|:..|
  Rat  1175 YHEMGFMYWTDWGENAKLERSGMDGSDRTVLINNNLGWPNGLTVDKTSSQLLWADAHTERIEVAD 1239

  Fly  1416 YTGNQRKLIMSSLHHPYALALSDDNIYWTDWKSKALHMTERRNISAKRDIITNIDGLMDIKIIYQ 1480
            ..|..|..::|.:.|||.|.|.|..||||||:::::|..::...|....:.:|:.|||||:.:  
  Rat  1240 LNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKSTGSNVILVRSNLPGLMDIQAV-- 1302

  Fly  1481 NQNQSTMKNACGNNNGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGM 1545
            ::.|....|.||:.||.||||||..|||:||.||.|::|:.:..| |...||.|||.:.|..|..
  Rat  1303 DRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKT-CDPSPETYLLFSSRGSIRR 1366

  Fly  1546 ISLNSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTESKVIVGTDVLTP 1610
            |||::.|..||.:|:.|::..:.|||......:::.||.||||||.: ||.:..:.::|..:.|.
  Rat  1367 ISLDTDDHTDVHVPVPGLNNVISLDYDSVDGKVYYTDVFLDVIRRAD-LNGSNMETVIGHGLKTT 1430

  Fly  1611 NGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSSPAK 1675
            :|:||||:|.||||:||.|..||.|||||||||.::.::|.:||::.|.|:|.||||:||...||
  Rat  1431 DGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAK 1495

  Fly  1676 IERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPF 1740
            |||:.||||.|.|:|.:.:|:|.|||:|:..||:.|.||..|.|...|.|||.||.:|.:..|||
  Rat  1496 IERANLDGSERKVLINADLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPF 1560

  Fly  1741 GLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQPKSVNHCAQDN 1805
            .||..:..|:||||..||:.|..|.  || .|...|...:.|.:||..||..|| ...|.|..:|
  Rat  1561 ALTQQDRWIYWTDWQTKSIQRVDKY--SG-RNKETVLANVEGLMDIIVVSPQRQ-TGTNACGVNN 1621

  Fly  1806 GGCTHLCLNRNVDYVCACPDVMDPKDVACSIKPKVLVHAN-----------LENDQLLEYSDEST 1859
            |||:|||..|..|:||||||  :|....||:.|.::..|.           |.|.........:|
  Rat  1622 GGCSHLCFARASDFVCACPD--EPDSHPCSLVPGLMPPAPRATSLNEKSPVLPNTLPTTLHSSTT 1684

  Fly  1860 DDSTPPELLGESNDHGDDGHTKKSDQE----------------REFFVLVALGVVIVMVVIIILV 1908
            ...|.||        |.:|...:.|.:                ....|..|:|.::.:::|:::.
  Rat  1685 RTRTSPE--------GAEGRCSERDAQLGLCAHSNEAVPAAPGEGLHVSYAVGGLLSVLLILLVT 1741

  Fly  1909 IFMLAFNTSKKKNKRNSRGSSRSVLTFSNPNYNVDGTPME----PKTNIWKRFKYDK 1961
            ..::.:...|.|......|:    ||:|||:|......::    ||..::.:..|.|
  Rat  1742 AALMLYRHRKSKFTDPGMGN----LTYSNPSYRTSTQEVKIEAAPKPAMYNQLCYKK 1794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 19/33 (58%)
LDLa 306..340 CDD:238060 17/33 (52%)
LDLa 347..390 CDD:238060 19/42 (45%)
LDLa 397..431 CDD:238060 14/33 (42%)
LDLa 442..476 CDD:238060 15/33 (45%)
LDLa 480..521 CDD:238060 13/43 (30%)
FXa_inhibition 576..604 CDD:464251 17/27 (63%)
LY 634..671 CDD:214531 20/36 (56%)
LY 680..714 CDD:214531 24/33 (73%)
LY 718..760 CDD:214531 20/41 (49%)
Ldl_recept_b 740..777 CDD:459654 17/36 (47%)
LY 761..803 CDD:214531 21/41 (51%)
LY 806..838 CDD:214531 18/31 (58%)
FXa_inhibition 882..912 CDD:464251 13/29 (45%)
LY 946..985 CDD:214531 18/38 (47%)
NHL <967..1142 CDD:302697 95/175 (54%)
LY 988..1030 CDD:214531 25/41 (61%)
NHL repeat 998..1037 CDD:271333 27/38 (71%)
NHL repeat 1038..1080 CDD:271333 23/41 (56%)
NHL repeat 1084..1119 CDD:271333 18/34 (53%)
FXa_inhibition 1185..1220 CDD:464251 16/36 (44%)
NHL 1260..>1445 CDD:302697 81/184 (44%)
NHL repeat 1260..1296 CDD:271320 13/35 (37%)
LY 1292..1334 CDD:214531 21/41 (51%)
NHL repeat 1302..1337 CDD:271320 20/34 (59%)
NHL repeat 1345..1383 CDD:271320 17/37 (46%)
FXa_inhibition <1499..1525 CDD:464251 14/25 (56%)
LY 1600..1640 CDD:214531 21/39 (54%)
LY 1643..1686 CDD:214531 22/42 (52%)
LY 1688..1729 CDD:214531 19/40 (48%)
FXa_inhibition 1801..>1825 CDD:464251 14/23 (61%)
Lrp4NP_112612.2 LDLa 27..66 CDD:238060 2/14 (14%)
Ldl_recept_a 70..105 CDD:395011 12/34 (35%)
LDLa 110..142 CDD:238060 14/31 (45%)
LDLa 148..182 CDD:238060 14/33 (42%)
LDLa 231..265 CDD:238060 16/34 (47%)
LDLa 270..304 CDD:238060 9/33 (27%)
LDLa 311..343 CDD:197566 15/35 (43%)
FXa_inhibition 358..393 CDD:464251 12/41 (29%)
EGF_CA 395..434 CDD:214542 12/38 (32%)
LY 460..502 CDD:214531 21/41 (51%)
LDL-receptor class B 1 480..522 21/41 (51%)
LY 505..545 CDD:214531 22/39 (56%)
LDL-receptor class B 2 523..565 26/41 (63%)
LDL-receptor class B 3 566..609 20/42 (48%)
Ldl_recept_b 566..607 CDD:459654 18/40 (45%)
LY 590..632 CDD:214531 19/41 (46%)
LDL-receptor class B 4 610..652 20/41 (49%)
LY 633..673 CDD:214531 23/39 (59%)
LDL-receptor class B 5 653..693 21/39 (54%)
FXa_inhibition 702..>729 CDD:464251 14/26 (54%)
YncE 749..982 CDD:442618 118/234 (50%)
LDL-receptor class B 6 785..827 18/42 (43%)
LY 808..850 CDD:214531 20/41 (49%)
LDL-receptor class B 7 828..870 22/41 (54%)
LDL-receptor class B 8 871..914 27/42 (64%)
Ldl_recept_b 871..912 CDD:459654 27/40 (68%)
LY 895..937 CDD:214531 21/41 (51%)
LDL-receptor class B 9 915..956 21/40 (53%)
LDL-receptor class B 10 957..998 20/41 (49%)
FXa_inhibition 1006..1043 CDD:464251 15/36 (42%)
NHL <1085..1277 CDD:302697 82/192 (43%)
NHL repeat 1085..1123 CDD:271320 15/38 (39%)
LDL-receptor class B 11 1093..1135 15/42 (36%)
NHL repeat 1128..1161 CDD:271320 11/32 (34%)
LDL-receptor class B 12 1136..1178 19/41 (46%)
NHL repeat 1166..1203 CDD:271320 18/36 (50%)
LDL-receptor class B 13 1179..1222 20/42 (48%)
Ldl_recept_b 1179..1219 CDD:459654 18/39 (46%)
NHL repeat 1212..1244 CDD:271320 17/31 (55%)
LDL-receptor class B 14 1223..1263 16/39 (41%)
NHL repeat 1253..1277 CDD:271320 7/23 (30%)
LDL-receptor class B 15 1264..1306 17/41 (41%)
FXa_inhibition 1313..1348 CDD:464251 11/34 (32%)
Vgb 1332..1583 CDD:443399 120/250 (48%)
LDL-receptor class B 16 1397..1439 15/41 (37%)
LDL-receptor class B 17 1440..1482 19/41 (46%)
LDL-receptor class B 18 1483..1526 23/42 (55%)
Ldl_recept_b 1483..1524 CDD:459654 23/40 (58%)
LDL-receptor class B 19 1527..1568 21/40 (53%)
LDL-receptor class B 20 1569..1610 19/40 (48%)
FXa_inhibition 1617..>1641 CDD:464251 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1659..1696 16/36 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1853..1905
Blue background indicates that the domain is not in the aligned region.

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