DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and si:dkey-88l16.3

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_073770595.1 Gene:si:dkey-88l16.3 / 796880 ZFINID:ZDB-GENE-030131-6015 Length:3896 Species:Danio rerio


Alignment Length:1319 Identity:369/1319 - (27%)
Similarity:580/1319 - (43%) Gaps:230/1319 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 TMESSVPSKTRISGGTNSNDTPKFRNIGAQRGRTEIAGIRETDRISSRGR--DGFIGGPSNKQKP 177
            |.|::.||   |...:|::   ..:.:|.   |:.....:||.:.....:  ||.:..||...:.
Zfish  2568 TDEANCPS---IPDASNAD---PLKTLGC---RSPSMFCKETSKCMPESQLCDGKVDCPSGADEQ 2623

  Fly   178 FRVNLAVLVQDDPSQ--------------PGETYSNCQNSNESDE--------NCNPEEDAVPNL 220
            |    .:....||..              ..:.||:|  ::.|||        .|:.:...:...
Zfish  2624 F----CIYSCSDPDHFLCKDKRKCVHKAVVCDGYSHC--ADGSDEYQCPTCALQCDQKTVCLTKQ 2682

  Fly   221 QR-----DC-----EK----------TGIHVMCPRTFR-------CISKYWLCDGDDDCGDYSDE 258
            ||     ||     ||          |.:.:.||...:       |:....||||:.||.|.|||
Zfish  2683 QRCDGKPDCRDGSDEKDCYTGGVIASTSLPLRCPLGSKPCMDGKECVLLDHLCDGEKDCKDGSDE 2747

  Fly   259 THCGARTNCTDDQFECLNG-FCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLA 322
            ..|  ...|...||:|.:| .||...:||||...|:|.|||.:|.:.:....|...|...|:...
Zfish  2748 RTC--ERKCKKGQFQCSHGRKCIDMKFVCDGTPQCQDRSDEANCMKLSDECRHQCDNKTRCVPET 2810

  Fly   323 FRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDE 387
            |.||||.||.|.:||..|  |:..|....|:|         .:|||:....||||..||.|.:||
Zfish  2811 FLCDGEKDCVDGTDEANC--VVEPCSGDRFQC---------SNGQCVALSLRCDGYADCRDHTDE 2864

  Fly   388 ENCPQKPSLCTSNEYKCA-DGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTC-N 450
            :.|||.|. |.. :::|. ...|:.|.|.||.::||..|.||.:|.:.    ||.||..:::| :
Zfish  2865 KGCPQPPH-CPL-DHRCPHTHECLLKEWLCDGDKDCSDGSDERNCKAT----PLKCGEFQWSCAS 2923

  Fly   451 NGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAG 515
            ..:||.|||.|||..||....||..|      ||..|||.........|:....:|:..::|..|
Zfish  2924 RTQCIAKTWRCDGMKDCQDESDESGC------GQTKCPTHLFQCGSGECMDPDLVCNKASDCADG 2982

  Fly   516 EDEADCPKERKCSEP-SP-CEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQ 578
            .||.....:..||.| || |:..||.|..|: .|.|:.|:.:..:.::|.|||||:.:....||.
Zfish  2983 SDEGVGCLKNNCSSPGSPSCQHYCINTPHGA-RCGCKTGFKLHSDGLSCVDIDECKEIQPAACSH 3046

  Fly   579 KCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTL-SNNRYSAIVKGLHNAI 642
            ||.|.:||:.|.|...::|.||..|||. ....:|||:.:.::..:.| |.:..:....|.....
Zfish  3047 KCFNRLGSYICQCHPEFLLEPDGHSCKT-ADEPSLLVSEQDELLNMGLRSFSIQTLTAPGRKPIF 3110

  Fly   643 ALDFHHRKGLMFWSDVSTDVIKMVY-----MNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSG 702
            :||:..|:..::|:.:..:.||..:     ..||.|:     |::| ..||:||:...|:|.|..
Zfish  3111 SLDYDLRERRVYWASLEDESIKYAFHGEKDNTGTIVK-----GVKS-DCIAIDWMGRNLYWVDGV 3169

  Fly   703 TRRVEVSNFQGNL-----RTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKV 762
            ..::.......::     ..|:...||.:|.::|:.|.:.:..||..|...:|.|:.|||:.|:.
Zfish  3170 AGQILAVRLTNSVVHPQNYVVVLDEDLKQPNSLVLLPQKGIMLWSQVGGQAQIGRSSMDGSDRRA 3234

  Fly   763 IISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWT 827
            :|.:|:.||..:.:|....::||.|.|...|..:.|||.:...:..:|:|.|.::.:|.|.:||:
Zfish  3235 VIRRGLNWPVSVTVDILTDRLYWTDKKLGCIGSATLDGENIRFLQLSHMPSPLSMAVFNDMIYWS 3299

  Fly   828 DWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCL--P 890
            |...::|..|:|:|||..:...:....|..:...||.:||...:.||...      |||:||  |
Zfish  3300 DTQRRSVQGANKLTGKNRKVFLKRPGQPFALKVVHPLQQPNVPNPCQSLH------CSHVCLLAP 3358

  Fly   891 NKTSRRCGCPIGLSLKEDGKTCKSTADK----LVLV-----------ARRKDIRLRHLRDNQADP 940
            . ....|.||....|..||.||.||.|.    |:|:           :.:.::.|:...::::  
Zfish  3359 G-LKAVCRCPTRAPLAADGLTCGSTLDDSSSYLMLLSLTTITQIFTKSMQSEVGLKQWPNHRS-- 3420

  Fly   941 NDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERS-TINKAHLNGSYQQRVVHSNLVSPVG---- 1000
                  :||..:..|      ||.|.:.   .:|| |:..|.: ||..|..:.|:..||:|    
Zfish  3421 ------LPLLGVSEA------SDFDMLL---QDRSITLADASV-GSVSQLGLRSSGFSPIGLVLQ 3469

  Fly  1001 --------LALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSD 1057
                    |||||:|..|||:......:.|.:..||:..:::..:|.....|.::|..|.|.::.
Zfish  3470 LKGDILSALALDWVTKNLYWSSMKRPELFVTSPGGKLTAVVLQAELAGTVSIALHPPSGRMCFTA 3534

  Fly  1058 WGDD-----PMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGR 1117
            .|..     |.::.|:|||..|..:.||..: |..||:..:.:.:|:.|.|:..:.::|.|||..
Zfish  3535 VGRRGADMLPQVDCAHMDGANRTRLWSKAKM-PVSLALSEKGNTLYWADIGSDLICSVNIDGSNY 3598

  Fly  1118 QVILNGLGHPFGLDVNEGRVFWTDWD--TKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRR 1180
            :....|..........:...||...|  |..:..::.|..|  .:.....|.:::::.:.|:.::
Zfish  3599 KEFSTGSEFMVSFARIDNIYFWITLDNGTSQLWYSDGLQPK--QMWFEVKTSVIELKAYSRSSQK 3661

  Fly  1181 IFNACDKLNGGCSHLCLLNPTSYTCACT------------------VGVQLKEDRHTCSEGPTQY 1227
            .||||...|||||||||.||...||.|.                  ||::...||..|       
Zfish  3662 GFNACSMSNGGCSHLCLPNPGGRTCRCAQDYLSVNNTKCVSSLKCPVGLKACRDRLKC------- 3719

  Fly  1228 ILFAHRIDIRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQ 1292
            |..|...|                .:|...:|...:.||       ..|...|...|.|..|...
Zfish  3720 IPVAKFCD----------------QVPDCQDASDEECDR-------VKTKPGVKSKSGPGSLDSA 3761

  Fly  1293 KIVGDSLENPDGLVVDSIG 1311
            ..:..|.||  |:||:::|
Zfish  3762 VELSPSSEN--GVVVENVG 3778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 16/34 (47%)
LDLa 306..340 CDD:238060 13/33 (39%)
LDLa 347..390 CDD:238060 15/42 (36%)
LDLa 397..431 CDD:238060 12/34 (35%)
LDLa 442..476 CDD:238060 15/34 (44%)
LDLa 480..521 CDD:238060 11/40 (28%)
FXa_inhibition 576..604 CDD:464251 12/27 (44%)
LY 634..671 CDD:214531 7/41 (17%)
LY 680..714 CDD:214531 9/33 (27%)
LY 718..760 CDD:214531 14/41 (34%)
Ldl_recept_b 740..777 CDD:459654 13/36 (36%)
LY 761..803 CDD:214531 13/41 (32%)
LY 806..838 CDD:214531 9/31 (29%)
FXa_inhibition 882..912 CDD:464251 12/31 (39%)
LY 946..985 CDD:214531 10/39 (26%)
NHL <967..1142 CDD:302697 50/192 (26%)
LY 988..1030 CDD:214531 17/53 (32%)
NHL repeat 998..1037 CDD:271333 14/50 (28%)
NHL repeat 1038..1080 CDD:271333 12/46 (26%)
NHL repeat 1084..1119 CDD:271333 10/34 (29%)
FXa_inhibition 1185..1220 CDD:464251 19/52 (37%)
NHL 1260..>1445 CDD:302697 14/52 (27%)
NHL repeat 1260..1296 CDD:271320 7/35 (20%)
LY 1292..1334 CDD:214531 7/20 (35%)
NHL repeat 1302..1337 CDD:271320 4/10 (40%)
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
si:dkey-88l16.3XP_073770595.1 None
Blue background indicates that the domain is not in the aligned region.

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