DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and VLDLR

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_003374.3 Gene:VLDLR / 7436 HGNCID:12698 Length:873 Species:Homo sapiens


Alignment Length:926 Identity:292/926 - (31%)
Similarity:421/926 - (45%) Gaps:177/926 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 TGIHVMC-PRTF-----RCISKYWLCDGDDDCGDYSDETHCGARTNCTDDQFECLNGFCIPRTWV 285
            ||....| |..|     |||:..|.||||:||.|.|||.:|..:| |.:..|.|.||.|:|..|.
Human    27 TGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKT-CAESDFVCNNGQCVPSRWK 90

  Fly   286 CDGENDCKDFSDET--HCNRTTCTDEHFTC--NDGYCISLAFRCDGEHDCNDNSDELKCAAVINS 346
            |||:.||:|.|||:  .|:..||.....:|  :...||.:::|||||:||:...||..|..:  :
Human    91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNI--T 153

  Fly   347 CPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIP 411
            |...||.|         .||:||...|.|:|.:||.|.|||.:|  .|..|.::|::|:..:|||
Human   154 CSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC--APPTCGAHEFQCSTSSCIP 207

  Fly   412 KRWKCDKEQDCDGGEDEN--DCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEV 474
            ..|.||.:.||....||:  .||.....| ..|.:.|..|.:|.||.|.|.|||.|||..|.|||
Human   208 ISWVCDDDADCSDQSDESLEQCGRQPVIH-TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV 271

  Fly   475 ECHLQ-CDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCSEPSP------ 532
            .|..: |...||.|....       |:|....|:|..:|..|.||.:|....:|..|..      
Human   272 NCPSRTCRPDQFECEDGS-------CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG 329

  Fly   533 -------------------------------------CEQLCIETTAGSNECACRLGYVMDKNKV 560
                                                 |..:|.:...| .||.|..|:.:...| 
Human   330 ECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIG-YECDCAAGFELIDRK- 392

  Fly   561 NCTDIDECQYLTSP-VCSQKCHNTMGSFKCSCETGYILRPDLRS--CKALGGAMTLLVANRWDIR 622
            .|.||||||   :| :|||.|.|..|.:||.|..||  :.||.:  |||:|...:|:..||.|||
Human   393 TCGDIDECQ---NPGICSQICINLKGGYKCECSRGY--QMDLATGVCKAVGKEPSLIFTNRRDIR 452

  Fly   623 RVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMN---GTRVRDVIKWGLESP 684
            ::.|....|..:|:.|.|.:|||.......:||:|:|...|....::   |..|:.:.  .:.:|
Human   453 KIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMID--NVYNP 515

  Fly   685 GGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPK 749
            ..|||||::..::|||:.::.:.|:...|..|..:.:.||.:|.:|.|.|.....:|||||...|
Human   516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAK 580

  Fly   750 IERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILST--HLP 812
            ||:|.|:|..|:.:::..:.||||:.:|...|::||.|:|.|.:...:|:|.||..:|.:  .|.
Human   581 IEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645

  Fly   813 HPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDR 877
            ||.|||:|||.:||.|...:.|..|:|.||.|...:..|.:...||..||...||...:.|::|.
Human   646 HPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDM 710

  Fly   878 RGLRGGCSHLCLP----NKTSRR--CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDN 936
            .  .|||.:||||    |..|.:  |.||.|.:::|:|:.|:||| ..|..:..||       .|
Human   711 E--NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTA-TTVTYSETKD-------TN 765

  Fly   937 QADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGL 1001
            ..:.:....:||                                  .|......|....|.|.|.
Human   766 TTEISATSGLVP----------------------------------GGINVTTAVSEVSVPPKGT 796

  Fly  1002 ALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIER 1066
            :..|                      .:..||:         :|:..:.|::.|.:|....| :.
Human   797 SAAW----------------------AILPLLL---------LVMAAVGGYLMWRNWQHKNM-KS 829

  Fly  1067 ANMDGHERVTITSKKL 1082
            .|.|....:..|.:.|
Human   830 MNFDNPVYLKTTEEDL 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/35 (49%)
LDLa 306..340 CDD:238060 13/35 (37%)
LDLa 347..390 CDD:238060 17/42 (40%)
LDLa 397..431 CDD:238060 13/35 (37%)
LDLa 442..476 CDD:238060 18/33 (55%)
LDLa 480..521 CDD:238060 12/40 (30%)
FXa_inhibition 576..604 CDD:291342 13/29 (45%)
LY 634..671 CDD:214531 11/39 (28%)
NHL <656..793 CDD:302697 46/139 (33%)
LY 680..714 CDD:214531 10/33 (30%)
NHL repeat 681..722 CDD:271320 12/40 (30%)
NHL repeat 726..760 CDD:271320 15/33 (45%)
LY 761..803 CDD:214531 13/41 (32%)
NHL repeat 769..793 CDD:271320 11/23 (48%)
FXa_inhibition 882..912 CDD:291342 15/35 (43%)
LY 946..985 CDD:214531 2/38 (5%)
NHL <967..1142 CDD:302697 17/116 (15%)
LY 988..1030 CDD:214531 5/41 (12%)
NHL repeat 998..1037 CDD:271320 5/38 (13%)
NHL repeat 1038..1080 CDD:271320 8/41 (20%)
NHL repeat 1084..1119 CDD:271320
FXa_inhibition 1185..1220 CDD:291342
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:291342
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
VLDLRNP_003374.3 LDLa 33..67 CDD:238060 17/33 (52%)
LDLa 71..103 CDD:197566 16/32 (50%)
Ldl_recept_a 111..149 CDD:278486 14/37 (38%)
LDLa 154..188 CDD:238060 17/42 (40%)
Ldl_recept_a 192..224 CDD:278486 11/31 (35%)
Ldl_recept_a 237..273 CDD:278486 18/35 (51%)
Ldl_recept_a 276..312 CDD:278486 12/42 (29%)
Ldl_recept_a 320..350 CDD:278486 1/29 (3%)
FXa_inhibition 360..394 CDD:291342 8/35 (23%)
EGF_CA 396..426 CDD:214542 18/34 (53%)
Ldl_recept_b 481..521 CDD:278487 10/41 (24%)
LY 505..547 CDD:214531 12/43 (28%)
Ldl_recept_b 568..608 CDD:278487 16/39 (41%)
LY 592..634 CDD:214531 13/41 (32%)
Ldl_recept_b 655..694 CDD:278487 13/38 (34%)
FXa_inhibition 706..749 CDD:291342 17/44 (39%)
Mucin <751..813 CDD:250634 18/134 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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