DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and VLDLR

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_003374.3 Gene:VLDLR / 7436 HGNCID:12698 Length:873 Species:Homo sapiens


Alignment Length:926 Identity:292/926 - (31%)
Similarity:421/926 - (45%) Gaps:177/926 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 TGIHVMC-PRTF-----RCISKYWLCDGDDDCGDYSDETHCGARTNCTDDQFECLNGFCIPRTWV 285
            ||....| |..|     |||:..|.||||:||.|.|||.:|..:| |.:..|.|.||.|:|..|.
Human    27 TGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKT-CAESDFVCNNGQCVPSRWK 90

  Fly   286 CDGENDCKDFSDET--HCNRTTCTDEHFTC--NDGYCISLAFRCDGEHDCNDNSDELKCAAVINS 346
            |||:.||:|.|||:  .|:..||.....:|  :...||.:::|||||:||:...||..|..:  :
Human    91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNI--T 153

  Fly   347 CPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIP 411
            |...||.|         .||:||...|.|:|.:||.|.|||.:|  .|..|.::|::|:..:|||
Human   154 CSPDEFTC---------SSGRCISRNFVCNGQDDCSDGSDELDC--APPTCGAHEFQCSTSSCIP 207

  Fly   412 KRWKCDKEQDCDGGEDEN--DCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEV 474
            ..|.||.:.||....||:  .||.....| ..|.:.|..|.:|.||.|.|.|||.|||..|.|||
Human   208 ISWVCDDDADCSDQSDESLEQCGRQPVIH-TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV 271

  Fly   475 ECHLQ-CDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCSEPSP------ 532
            .|..: |...||.|....       |:|....|:|..:|..|.||.:|....:|..|..      
Human   272 NCPSRTCRPDQFECEDGS-------CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG 329

  Fly   533 -------------------------------------CEQLCIETTAGSNECACRLGYVMDKNKV 560
                                                 |..:|.:...| .||.|..|:.:...| 
Human   330 ECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIG-YECDCAAGFELIDRK- 392

  Fly   561 NCTDIDECQYLTSP-VCSQKCHNTMGSFKCSCETGYILRPDLRS--CKALGGAMTLLVANRWDIR 622
            .|.||||||   :| :|||.|.|..|.:||.|..||  :.||.:  |||:|...:|:..||.|||
Human   393 TCGDIDECQ---NPGICSQICINLKGGYKCECSRGY--QMDLATGVCKAVGKEPSLIFTNRRDIR 452

  Fly   623 RVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMN---GTRVRDVIKWGLESP 684
            ::.|....|..:|:.|.|.:|||.......:||:|:|...|....::   |..|:.:.  .:.:|
Human   453 KIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMID--NVYNP 515

  Fly   685 GGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPK 749
            ..|||||::..::|||:.::.:.|:...|..|..:.:.||.:|.:|.|.|.....:|||||...|
Human   516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAK 580

  Fly   750 IERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILST--HLP 812
            ||:|.|:|..|:.:::..:.||||:.:|...|::||.|:|.|.:...:|:|.||..:|.:  .|.
Human   581 IEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645

  Fly   813 HPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDR 877
            ||.|||:|||.:||.|...:.|..|:|.||.|...:..|.:...||..||...||...:.|::|.
Human   646 HPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDM 710

  Fly   878 RGLRGGCSHLCLP----NKTSRR--CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDN 936
            .  .|||.:||||    |..|.:  |.||.|.:::|:|:.|:||| ..|..:..||       .|
Human   711 E--NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTA-TTVTYSETKD-------TN 765

  Fly   937 QADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGL 1001
            ..:.:....:||                                  .|......|....|.|.|.
Human   766 TTEISATSGLVP----------------------------------GGINVTTAVSEVSVPPKGT 796

  Fly  1002 ALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIER 1066
            :..|                      .:..||:         :|:..:.|::.|.:|....| :.
Human   797 SAAW----------------------AILPLLL---------LVMAAVGGYLMWRNWQHKNM-KS 829

  Fly  1067 ANMDGHERVTITSKKL 1082
            .|.|....:..|.:.|
Human   830 MNFDNPVYLKTTEEDL 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/35 (49%)
LDLa 306..340 CDD:238060 13/35 (37%)
LDLa 347..390 CDD:238060 17/42 (40%)
LDLa 397..431 CDD:238060 13/35 (37%)
LDLa 442..476 CDD:238060 18/33 (55%)
LDLa 480..521 CDD:238060 12/40 (30%)
FXa_inhibition 576..604 CDD:464251 13/29 (45%)
LY 634..671 CDD:214531 11/39 (28%)
LY 680..714 CDD:214531 10/33 (30%)
LY 718..760 CDD:214531 17/41 (41%)
Ldl_recept_b 740..777 CDD:459654 16/36 (44%)
LY 761..803 CDD:214531 13/41 (32%)
LY 806..838 CDD:214531 14/33 (42%)
FXa_inhibition 882..912 CDD:464251 15/35 (43%)
LY 946..985 CDD:214531 2/38 (5%)
NHL <967..1142 CDD:302697 17/116 (15%)
LY 988..1030 CDD:214531 5/41 (12%)
NHL repeat 998..1037 CDD:271333 5/38 (13%)
NHL repeat 1038..1080 CDD:271333 8/41 (20%)
NHL repeat 1084..1119 CDD:271333
FXa_inhibition 1185..1220 CDD:464251
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
LY 1292..1334 CDD:214531
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
VLDLRNP_003374.3 LDLa 33..67 CDD:238060 17/33 (52%)
LDLa 71..103 CDD:197566 16/32 (50%)
Ldl_recept_a 111..149 CDD:395011 14/37 (38%)
LDLa 154..188 CDD:238060 17/42 (40%)
Ldl_recept_a 192..224 CDD:395011 11/31 (35%)
Ldl_recept_a 237..273 CDD:395011 18/35 (51%)
Ldl_recept_a 276..312 CDD:395011 12/42 (29%)
Ldl_recept_a 320..350 CDD:395011 1/29 (3%)
FXa_inhibition 360..394 CDD:464251 8/35 (23%)
EGF_CA 396..426 CDD:214542 18/34 (53%)
Ldl_recept_b 481..522 CDD:459654 11/42 (26%)
LY 505..547 CDD:214531 12/43 (28%)
Ldl_recept_b 568..608 CDD:459654 16/39 (41%)
LY 592..634 CDD:214531 13/41 (32%)
Ldl_recept_b 655..695 CDD:459654 13/39 (33%)
FXa_inhibition 706..749 CDD:464251 17/44 (39%)
Blue background indicates that the domain is not in the aligned region.

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