DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and vldlr

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	XP_002934223.1	Gene:	vldlr / 733485	XenbaseID:	XB-GENE-971958	Length:	868	Species:	Xenopus tropicalis

Alignment Length:	860	Identity:	282/860 - (32%)
Similarity:	402/860 - (46%)	Gaps:	128/860 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 CEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHCGARTNCTDDQFECLNGFCIPRTWVCDG 288
            ||  |....|... .||:..|.||||:||.|.|||:.|..:| |.:..|.|.||.|:||.|.|||
Frog    31 CE--GSQFQCANG-HCITSLWKCDGDEDCSDGSDESSCVKKT-CAETDFVCNNGLCVPRRWECDG 91

  Fly   289 ENDCKDFSDETH--CNRTTCTDEHFTC--NDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPE 349
            :.||:|.||||.  |:..||.....:|  ....||.|:::||||.||.:..||..|..:  :|..
Frog    92 DPDCEDGSDETAELCHMRTCRATEISCGARSTQCIPLSWKCDGESDCPNAEDEENCGNI--TCSP 154

  Fly   350 GEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPKRW 414
            .||.|         .||:||.:.|.|:|.|||.|.||||||  .|..|.::|::|.:.:|||..|
Frog   155 AEFTC---------SSGRCISSTFVCNGQNDCSDGSDEENC--VPPTCGAHEFQCKNSSCIPLNW 208

  Fly   415 KCDKEQDCDGGEDEN--DCGSLGSEHPLT---CGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEV 474
            .||.:.||....||:  .||    ..|:.   |.::|..|.:|.||.|.|.|||.|||....||:
Frog   209 VCDDDSDCADHSDESLEQCG----RQPIAPQKCSANEMPCGSGECIHKKWRCDGDPDCKDKSDEM 269

  Fly   475 ECHLQ-CDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCSEPSP------ 532
            .|..: |...||.|....       |:|....|||..:|..|.||..|....:||.|..
Frog   270 NCPSRTCQPDQFKCEDGN-------CIHGSRQCDGVRDCLDGTDEIRCKNVNQCSGPGKFKCRSG 327

  Fly   533 -------------------------------------CEQLCIETTAGSNECACRLGYVMDKNKV 560
                                                 |..||.....| .||.|..|:.:...|
Frog   328 ECIDIAKVCNKQKDCKDWSDEPIKECYVNECEVNNGGCSHLCHNLVIG-YECDCTAGFKLIDRK- 390

  Fly   561 NCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVT 625
            .|.||||||  ...:|||.|.|..|.:||.|..||.:.|....|||:|....|:..||.|||:|.
Frog   391 TCGDIDECQ--NPEICSQICVNLKGGYKCECSKGYQMDPSTGVCKAVGREPCLIFTNRRDIRKVG 453

  Fly   626 LSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMN--------GTRVRDVIKWGLE 682
            |....|..:|:.|.|.:|||...::..:||:|.   :.|.::..        ||.:: |:: .:.
Frog   454 LERKEYIQLVEQLRNTVALDADIKEQSLFWADT---IQKAIFRAPFDTREKVGTHIK-VVE-DVH 513

  Fly   683 SPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPN 747
            ||..||:|||:..::|.|:|.:.:.||||.|:.|..:.:..|..|.:|.|.|.....:|||||..
Frog   514 SPSAIAIDWIYKNIYWMDTGLKTISVSNFDGSKRKTLFNSGLQDPTSIAVDPISGFIYWSDWGEP 578

  Fly   748 PKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTH-- 810
            .|||:|.|:|..|:..::..|..|:|:|||...|::||.|:|.|.:...:|:|.||..||.:|
Frog   579 AKIEKAGMNGIDRQQFVTADVQRPSGIAIDVVKSRLYWVDSKLHTLSSVDLNGLDRRVILKSHEF 643

  Fly   811 LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQK 875
            |.||.|||:|||.:||.|...:.:..|:|.:|:|...:..|.:...|:..||...||...:.|.:
Frog   644 LAHPLALTIFEDRVYWIDGENEAIYGANKFSGQELETLVNNLNEAQDVIVYHELVQPLGRNWCNE 708

  Fly   876 DRRGLRGGCSHLCLP------NKTSRRCGCPIGLSLKEDGKTC----KSTADKLVLVARRKDIRL 930
            ...  .|||.:||||      |.....|.||.|..| ..|::|    |:|.|..|     |...:
Frog   709 QIE--NGGCKYLCLPAPQISDNSPKYTCVCPDGFEL-NGGRSCRPGSKATMDHTV-----KPTGI 765

  Fly   931 RHLRDNQADPNDVDMIVPLDNLKHAVALDW----------CSDTDFIYWTDVERSTINKAHLNGS 985
            ...:...:..||.:.|..::......:..|          .:...::.|.:.::..:...:.:..
Frog   766 LPKKPLPSGDNDTNSIHEVNLSAKGTSAAWAILPLLLIAMAASGGYLMWRNWQQKNMKSMNFDNP 830

  Fly   986 YQQRVVHSNLVSPVG 1000
            ...:....:|...:|
Frog   831 VYLKTTEEDLAIDIG 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	19/35 (54%)
		LDLa	306..340	CDD:238060	13/35 (37%)
		LDLa	347..390	CDD:238060	19/42 (45%)
		LDLa	397..431	CDD:238060	13/35 (37%)
		LDLa	442..476	CDD:238060	16/33 (48%)
		LDLa	480..521	CDD:238060	13/40 (33%)
		FXa_inhibition	576..604	CDD:291342	12/27 (44%)
		LY	634..671	CDD:214531	10/44 (23%)
		NHL	<656..793	CDD:302697	50/144 (35%)
		LY	680..714	CDD:214531	14/33 (42%)
		NHL repeat	681..722	CDD:271320	16/40 (40%)
		NHL repeat	726..760	CDD:271320	15/33 (45%)
		LY	761..803	CDD:214531	14/41 (34%)
		NHL repeat	769..793	CDD:271320	11/23 (48%)
		FXa_inhibition	882..912	CDD:291342	14/35 (40%)
		LY	946..985	CDD:214531	3/48 (6%)
		NHL	<967..1142	CDD:302697	3/34 (9%)
		LY	988..1030	CDD:214531	2/13 (15%)
		NHL repeat	998..1037	CDD:271320	1/3 (33%)
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
vldlr	XP_002934223.1	LDLa	31..65	CDD:238060	17/36 (47%)
		Ldl_recept_a	68..101	CDD:365841	17/33 (52%)
		Ldl_recept_a	109..147	CDD:365841	14/37 (38%)
		Ldl_recept_a	151..186	CDD:365841	19/43 (44%)
		LDLa	190..222	CDD:197566	11/31 (35%)
		Ldl_recept_a	236..271	CDD:365841	16/34 (47%)
		Ldl_recept_a	274..310	CDD:365841	13/42 (31%)
		LDLa	316..348	CDD:197566	3/31 (10%)
		FXa_inhibition	358..392	CDD:373209	9/35 (26%)
		EGF_CA	394..424	CDD:214542	16/31 (52%)
		LY	505..547	CDD:214531	16/43 (37%)
		LY	548..591	CDD:214531	16/42 (38%)
		LY	592..634	CDD:214531	14/41 (34%)
		Ldl_recept_b	655..694	CDD:393440	10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910