DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and Lrp10

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_075369.2 Gene:Lrp10 / 65107 MGIID:1929480 Length:713 Species:Mus musculus


Alignment Length:306 Identity:80/306 - (26%)
Similarity:103/306 - (33%) Gaps:108/306 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   267 CTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHC------NRTTCTDEHFTCN----------- 314
            |..::|:|||..|||....|||.:.|.|.|||..|      |..........||           
Mouse   141 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGCSSDPFPNLNPAPAPTLACNLTLEDFYGVFS 205

  Fly   315 -DGY-----------CISLAFRCDGE------------------------------------HDC 331
             .||           |:.|....||.                                    |..
Mouse   206 SPGYSHLASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYGDAVHVYDGAGPPETPRLLRSLTHFS 270

  Fly   332 NDNS---DELKCAAVIN------SCPEG---EFKCRG-------------GLGGAGGPSGQCILN 371
            |..:   :.|...||::      |...|   .:..||             |||.:.....:|...
Mouse   271 NGKAVTVETLSGQAVVSYHTVAWSSGRGFNATYHVRGYCLPWDRPCGLGSGLGASENLGERCYSE 335

  Fly   372 RFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKC-ADGT-----CIPKRWKCDKEQDCDGGEDEND 430
            ..||||..||.|.:|||.||.    |....:.| |.||     |.....:|:.:..|..|.||..
Mouse   336 AQRCDGSWDCADGTDEEGCPG----CPPGHFPCGAAGTPGATACYLPADRCNYQTFCADGADERR 396

  Fly   431 CGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVEC 476
            |     .|   |....|.|.:.:|:.:||:|||.|||..|.||.:|
Mouse   397 C-----RH---CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 16/33 (48%)
LDLa 306..340 CDD:238060 11/95 (12%)
LDLa 347..390 CDD:238060 17/58 (29%)
LDLa 397..431 CDD:238060 11/39 (28%)
LDLa 442..476 CDD:238060 15/33 (45%)
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:291342
LY 634..671 CDD:214531
NHL <656..793 CDD:302697
LY 680..714 CDD:214531
NHL repeat 681..722 CDD:271320
NHL repeat 726..760 CDD:271320
LY 761..803 CDD:214531
NHL repeat 769..793 CDD:271320
FXa_inhibition 882..912 CDD:291342
LY 946..985 CDD:214531
NHL <967..1142 CDD:302697
LY 988..1030 CDD:214531
NHL repeat 998..1037 CDD:271320
NHL repeat 1038..1080 CDD:271320
NHL repeat 1084..1119 CDD:271320
FXa_inhibition 1185..1220 CDD:291342
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:291342
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
Lrp10NP_075369.2 CUB 35..135 CDD:238001
LDLa 141..175 CDD:238060 16/33 (48%)
CUB 193..303 CDD:238001 15/109 (14%)
LDLa <331..354 CDD:238060 11/22 (50%)
LDLa 400..434 CDD:238060 15/33 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 566..636
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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