DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp2a

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001181916.1 Gene:lrp2a / 568184 ZFINID:ZDB-GENE-050119-2 Length:4673 Species:Danio rerio


Alignment Length:1964 Identity:621/1964 - (31%)
Similarity:929/1964 - (47%) Gaps:254/1964 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 DLTKTAVKRNAPH---YGIHPTNALGRW-DW------------NKHKQLHSDARIGHLEAGNESR 71
            |.::.|:.||..:   ..:||......| ||            ..|.|...:..:|.        
Zfish   807 DKSRRAIVRNLNNPRSIVVHPVAGFIFWTDWYRPAKIMRAWGDGSHAQSIVNTTLGW-------- 863

  Fly    72 EDQLSEELSKFGEKLFPVSNYPPYQQNNEDSQEVHHS---GEGRL---HTMESSVPSKTRISGG- 129
            .:.|:.:.|..  :|:.|..:         ..::.||   |:.||   ...:.|.|....:.|| 
Zfish   864 PNGLAIDWSAM--RLYWVDAF---------FDKIEHSNFDGQNRLSLDRITQISHPFGLTVFGGY 917

  Fly   130 ----------------TNSNDTPKFRNIGAQRGRTEIAGIRETDRISSRGRDGFIG--------G 170
                            |:..:....|.           ||.....:.|...|..||        .
Zfish   918 VYFTDWRLGGIVRVRKTDGGEMMTIRR-----------GISHIMHVKSFNADSQIGFNFCSRQTN 971

  Fly   171 PS-----------NKQK----PFRVNLAVLVQ---DDPS------QPGETYSNCQNSNESDENCN 211
            |:           |.|:    |:.:.|....|   ||||      |.|....:|.|.     .|.
Zfish   972 PNGDCSHFCFPAPNSQRVCGCPYGMKLEANQQTCVDDPSNEPPTLQCGSNSFSCSNG-----KCV 1031

  Fly   212 PEE---DAVPNLQRDCEKTGIHVMC--------PRTF-----RCISKYWLCDGDDDCGDYSDETH 260
            |..   |.|.    ||........|        |..|     ||:.:.|.|||.:||.|.|||..
Zfish  1032 PHSYQCDGVD----DCHDNSDEAHCGAHNNTCSPLAFTCANQRCVPRSWHCDGHNDCFDGSDERD 1092

  Fly   261 CGART--NCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRT-TCTDEHFTCNDGYCISLA 322
            |..:|  .|..|||.|.|.:||||||:||.:|||.|.|||.:|:.. ||....|.|.|..||...
Zfish  1093 CPTQTPGTCPADQFICANHYCIPRTWLCDTDNDCGDGSDENNCDSIGTCYPGQFQCPDHRCIDPN 1157

  Fly   323 FRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDE 387
            :.|||:.||.|.:||..|   :.:|...||||..        ..||:.:.:||||..||.|.|||
Zfish  1158 YVCDGDRDCADGADEQGC---VYNCTAYEFKCAN--------DHQCVNSYYRCDGVFDCNDRSDE 1211

  Fly   388 ENCPQK-PSLC-TSNEYKC-ADGTCIPKRWKCDKEQDCDGGEDEND-CGSLGSEHPLTCGSDEFT 448
            ..||.: |.:| ..:|::| :||:|:|..|:||...||:.|.||:. |      .|.||.:.:|.
Zfish  1212 SGCPTRPPGMCHHESEFQCQSDGSCVPVNWECDGHPDCEDGSDEHHAC------PPRTCPTTQFR 1270

  Fly   449 CNNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLCPTKQ-NLTNLKICVHQKHICDGHNEC 512
            |:||.|:.:.|:|||..||..|.||.:    |....|.||::| ......:||:...:||...:|
Zfish  1271 CDNGNCVYRGWICDGDNDCRDGSDERD----CPTPPFRCPSRQWQCPGHSVCVNLSRVCDNTPDC 1331

  Fly   513 PAGEDEADCPKERKCSEPSPCEQLCIETTAGSN----------ECACRLGYVMDKNKVNCTDIDE 567
            |.|.||:..     |:||.|.::.|.:..||..          :|.|.:|:.:..:...|.||||
Zfish  1332 PNGADESPL-----CNEPLPDQESCSDNNAGCTHGCIQGPFGAQCTCPMGFQLSNDSKTCEDIDE 1391

  Fly   568 CQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGG-AMTLLVANRWDI--RRVTLSNN 629
            |.  ...||||.|.|..|||:|.|:.||.|..|.|:|||.|. ...||||:|..|  ..:....|
Zfish  1392 CH--PPGVCSQHCFNERGSFRCHCQDGYTLEADARTCKASGSREALLLVASRNQIISDDILAQPN 1454

  Fly   630 RYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHD 694
            ...::|:...|.:|:||......::|||.:.|.|...:.|||....:...|:.....:||||:..
Zfish  1455 AIRSLVRDGRNIVAVDFDSVTERIYWSDTTQDRIWSAHKNGTDRTVIFDSGVTVTESLAVDWVGR 1519

  Fly   695 LLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHP--GEALAFWSDWGPNPKIERAYMDG 757
            .|:|||.....:|||...|:.|||:.|.::..||.:||.|  ...|.||:|||.||:||||.|||
Zfish  1520 NLYWTDYILETIEVSKLDGSHRTVLISENVTNPRGLVVDPRNNTHLMFWTDWGRNPRIERASMDG 1584

  Fly   758 TQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTH--LPHPFALTLF 820
            ..|..|||..:.|||||.||:|||.:|:|||....|:..:.||.:|.::|::.  |.||.|:|:|
Zfish  1585 KLRTTIISNKLYWPNGLTIDYPNSLLYFADAYLDFIDYCDYDGKNRKQVLASDLVLQHPHAITIF 1649

  Fly   821 EDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCS 885
            ||.:||||.....|..|:|..|:....:..|...||.:.|.||||||...:.|...    ...|:
Zfish  1650 EDFVYWTDRYVNRVIRANKWHGQNQSVMLYNLPQPMGLVALHPARQPAGYNPCDPH----SSPCT 1710

  Fly   886 HLCLPNKTSRR---CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDV--DM 945
            |:||.:....|   |.||.|.:|..|..||....|..::|.|...|....|     :|||.  |.
Zfish  1711 HICLLSAVGPRFYSCACPSGWTLAADQFTCARVEDPFLVVVRDSIIYGIPL-----NPNDKSNDA 1770

  Fly   946 IVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLV-SPVGLALDWITDK 1009
            :||:..|.:...:|:......|||.: ....|::...:|:.:.....:.:: |||||||||::..
Zfish  1771 MVPVAGLLNGYDVDFDDAEQMIYWVE-HPGEIHRVKSDGTNRTEFAPAAILGSPVGLALDWMSQN 1834

  Fly  1010 LYWTDPSTNRIEVATTNGKM--RTLLIWEK-----LYKPRDIVVNPIEGFMFWSDWGDD----PM 1063
            ||:::||:..|||....|::  |..||...     ...|..|.|:|..|.|:|:|.|.:    ..
Zfish  1835 LYYSNPSSQAIEVLRLKGEIQYRKTLITNNGSPTGAGAPVGIAVDPARGKMYWTDHGTESGIPAK 1899

  Fly  1064 IERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVILNGLGHPF 1128
            :..|:|||.....:.:..|.:...:.||..::|:|:...||..:|..:.|||.|..::|||.||:
Zfish  1900 VASADMDGSNAAILFTHNLEHVEFITIDITENKLYWAVTGTGVIERGDPDGSNRITMVNGLSHPW 1964

  Fly  1129 GLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHR-TRRRIFNACDKLNGGC 1192
            |:.|....:::||.|.:.:...:|.||.:..|:..|...|..::|.|| :.....|.|....|.|
Zfish  1965 GVAVYGSYLYFTDRDFEVIERVDKATGLNRVVMRDNVAGLRVLKVHHRDSSAGSSNGCSNNVGTC 2029

  Fly  1193 SHLCLLNPTS-YTCACTVGVQLKEDRHTCSEGPTQ-YILFAHRIDIRQISLD-FDHLIDVVLPLP 1254
            ..|||..|.. ::|||..|.:|..|..|||  |.| |::.:....|:..||: .||...:|    
Zfish  2030 EQLCLPRPGGLFSCACATGFKLSADNRTCS--PYQSYVVISMLTAIKGFSLEGVDHSESMV---- 2088

  Fly  1255 PIS----NAVALDVDRKTGYIYWSD---TI--ENVIMSSSPDGLHVQKIV--GDSLENPDGLVVD 1308
            |::    ||:.:||...:.:|||.|   |:  :|.|....|||...:.||  |.......|:.||
Zfish  2089 PVAGRGRNALHVDVHMASSFIYWCDFSSTVASQNGIRRIKPDGSGFRSIVTSGIGRNGIRGIAVD 2153

  Fly  1309 SIGRTIYWADA--GRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERS 1371
            .....:|:.:|  ....|||..|:.:.|.|:....::.||.:.:|.:...|||.|:|...||||:
Zfish  2154 WAAGNLYFTNAFLTETYIEVIRLNTTFRRVLLKTQVDMPRHIVVDPKNRYLFWADYGQTPKIERA 2218

  Fly  1372 HLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIM--SSLHHPYAL 1434
            .|||:.|:.:|::.:..|.||:||.:...|||||..|..|......|.:.:::.  |....||.:
Zfish  2219 FLDGSNRTALVSSGIVTPRGLALDHRDGYIYWVDDSLDMIARVRPEGGETEVVRYGSRYPTPYGI 2283

  Fly  1435 ALSDDNIYWTDWKSKALHMTERRNISAKRDII--TNIDGLMDIKIIYQNQNQSTM----KNACGN 1493
            .:.:.|:.|.|...|.:....::..:..:..:  .||:.|.|:.|..:....|:.    .|.|..
Zfish  2284 TVFEGNVIWVDRNLKKVFRASKQPGATDQPAVIRDNINMLRDVTIFDRRMQPSSAHELNNNPCLE 2348

  Fly  1494 NNGNCSHLC--LRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDV 1556
            :||.|:|.|  :.......|.|..|.....:|:  |....:|||:....|.:..:.|:..|..  
Zfish  2349 SNGGCAHFCFAMAGAQTRKCSCAFGNLAADDSS--CVVSRDDYLIYTTESTVRSLRLDPDDHS-- 2409

  Fly  1557 VLP---INGVHGAVVLDYHYRKNLLFF---ADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGIAV 1615
             ||   :|....:|.||:......::|   :......|..:.|.:.|.....|.:|:..|:|||.
Zfish  2410 -LPFPVVNVPRTSVALDFDRLDGRIYFTQSSGAGQSKISFITLASPTSPATEVASDLGAPDGIAY 2473

  Fly  1616 DWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSSPAKIERSY 1680
            |||...:|:||...:.|....:|||  :|.|...:..||::::.|.:.|::|:||.:.|||||:.
Zfish  2474 DWINRRIYYSDYINQTISSMAVDGS--QRTVVAQVPRPRAIMLDPCRGYMYWTDWGTSAKIERAT 2536

  Fly  1681 LDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPFGLTLF 1745
            |.|:.||.|:.:.:.:|.|||:|:.::||.||||....|.:....|..|:.||..|.:||.:|::
Zfish  2537 LGGNFRTEIVNTSLVWPNGLTLDYDDQRLYWADASLQKIERCSLTGTNREVIVSTAIYPFAMTVY 2601

  Fly  1746 ENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTH 1810
            :..|:||||..:|:||:.|  ..|......:::..|..:||..:|.|:|.:..:.|.|.||||:|
Zfish  2602 DQHIYWTDWNTRSIYRANK--HDGSDQRVMLQNLPSRPMDIHVLSNSKQQQCSSPCEQFNGGCSH 2664

  Fly  1811 LCLNRNVDYVCACP 1824
            :|........|.||
Zfish  2665 ICTPGPQGAECQCP 2678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 21/33 (64%)
LDLa 306..340 CDD:238060 14/33 (42%)
LDLa 347..390 CDD:238060 17/42 (40%)
LDLa 397..431 CDD:238060 15/36 (42%)
LDLa 442..476 CDD:238060 15/33 (45%)
LDLa 480..521 CDD:238060 14/41 (34%)
FXa_inhibition 576..604 CDD:291342 15/27 (56%)
LY 634..671 CDD:214531 11/36 (31%)
NHL <656..793 CDD:302697 62/138 (45%)
LY 680..714 CDD:214531 12/33 (36%)
NHL repeat 681..722 CDD:271320 15/40 (38%)
NHL repeat 726..760 CDD:271320 20/35 (57%)
LY 761..803 CDD:214531 20/41 (49%)
NHL repeat 769..793 CDD:271320 14/23 (61%)
FXa_inhibition 882..912 CDD:291342 11/32 (34%)
LY 946..985 CDD:214531 8/38 (21%)
NHL <967..1142 CDD:302697 58/186 (31%)
LY 988..1030 CDD:214531 17/44 (39%)
NHL repeat 998..1037 CDD:271320 19/40 (48%)
NHL repeat 1038..1080 CDD:271320 13/45 (29%)
NHL repeat 1084..1119 CDD:271320 11/34 (32%)
FXa_inhibition 1185..1220 CDD:291342 13/35 (37%)
NHL 1260..>1445 CDD:302697 61/195 (31%)
NHL repeat 1260..1296 CDD:271320 14/42 (33%)
NHL repeat 1302..1337 CDD:271320 10/36 (28%)
NHL repeat 1345..1383 CDD:271320 16/37 (43%)
FXa_inhibition <1499..1525 CDD:291342 6/27 (22%)
LY 1600..1640 CDD:214531 14/39 (36%)
LY 1643..1686 CDD:214531 16/42 (38%)
LY 1688..1729 CDD:214531 14/40 (35%)
FXa_inhibition 1801..>1825 CDD:291342 11/24 (46%)
lrp2aNP_001181916.1 LDLa 23..57 CDD:238060
Ldl_recept_a 61..96 CDD:278486
LDLa 103..137 CDD:238060
LDLa 143..174 CDD:238060
LDLa 178..212 CDD:238060
LDLa 217..251 CDD:238060
LDLa 258..292 CDD:238060
NHL <429..610 CDD:302697
NHL repeat 461..496 CDD:271320
LY 495..540 CDD:214531
LY 543..583 CDD:214531
NHL repeat 550..591 CDD:271320
FXa_inhibition 655..696 CDD:291342
LY 768..804 CDD:214531
Ldl_recept_b 830..870 CDD:278487 7/47 (15%)
LY 854..896 CDD:214531 9/60 (15%)
FXa_inhibition 973..1005 CDD:291342 5/31 (16%)
LDLa 1018..1052 CDD:238060 9/42 (21%)
LDLa 1059..1093 CDD:238060 14/33 (42%)
LDLa 1101..1135 CDD:238060 21/33 (64%)
LDLa 1141..1175 CDD:238060 14/33 (42%)
LDLa 1179..1214 CDD:238060 17/42 (40%)
LDLa 1222..1255 CDD:197566 13/32 (41%)
LDLa 1264..1298 CDD:238060 15/37 (41%)
LDLa 1304..1337 CDD:197566 10/32 (31%)
FXa_inhibition 1351..1386 CDD:291342 6/34 (18%)
EGF_CA 1388..1418 CDD:214542 17/31 (55%)
LY 1459..1498 CDD:214531 13/38 (34%)
LY 1500..1541 CDD:214531 13/40 (33%)
LY 1543..1585 CDD:214531 21/41 (51%)
LY 1589..1630 CDD:214531 20/40 (50%)
FXa_inhibition 1709..1740 CDD:291342 11/30 (37%)
NHL <1799..1978 CDD:302697 55/178 (31%)
NHL repeat 1823..1866 CDD:271320 19/42 (45%)
NHL repeat 1872..1913 CDD:271320 13/40 (33%)
Ldl_recept_b 1883..1927 CDD:278487 10/43 (23%)
LY 1912..1953 CDD:214531 11/40 (28%)
NHL repeat 1920..1946 CDD:271320 7/25 (28%)
FXa_inhibition 2022..2058 CDD:291342 13/35 (37%)
NHL <2125..2295 CDD:302697 52/169 (31%)
NHL repeat 2149..2186 CDD:271320 11/36 (31%)
LY 2182..2225 CDD:214531 16/42 (38%)
NHL repeat 2189..2226 CDD:271320 15/36 (42%)
LY 2228..2267 CDD:214531 14/38 (37%)
NHL repeat 2235..2276 CDD:271320 13/40 (33%)
FXa_inhibition 2346..2382 CDD:291342 10/37 (27%)
LY 2461..2500 CDD:214531 16/40 (40%)
Ldl_recept_b 2519..2559 CDD:278487 18/39 (46%)
LY 2545..2585 CDD:214531 14/39 (36%)
Ldl_recept_b 2603..2642 CDD:278487 13/40 (33%)
FXa_inhibition 2655..2691 CDD:291342 11/24 (46%)
LDLa 2759..2793 CDD:238060
LDLa 2798..2835 CDD:238060
LDLa 2838..2872 CDD:294076
LDLa 2882..2913 CDD:238060
LDLa 2923..2955 CDD:197566
LDLa 2965..3002 CDD:197566
LDLa 3011..3045 CDD:238060
LDLa 3050..3083 CDD:238060
LDLa 3093..3127 CDD:238060
cEGF 3150..3173 CDD:289433
vWFA <3165..3206 CDD:294047
LY 3237..3279 CDD:214531
LY 3282..3321 CDD:214531
Ldl_recept_b 3350..3390 CDD:278487
LY 3376..3416 CDD:214531
LY 3417..3458 CDD:214531
FXa_inhibition 3486..>3514 CDD:291342
LDLa 3529..3561 CDD:238060
LDLa 3570..3602 CDD:238060
LDLa 3611..3643 CDD:238060
LDLa 3651..3683 CDD:197566
LDLa 3699..3731 CDD:238060
LDLa 3738..3771 CDD:238060
LDLa 3776..3810 CDD:238060
LDLa 3815..3849 CDD:238060
LDLa 3859..3891 CDD:238060
LDLa 3902..3932 CDD:197566
LDLa 3945..3979 CDD:238060
EGF_CA 4024..4055 CDD:214542
LY 4158..4193 CDD:214531
Ldl_recept_b 4214..4254 CDD:278487
LY 4238..4281 CDD:214531
FXa_inhibition 4356..>4377 CDD:291342
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 66 1.000 Domainoid score I9943
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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