DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp1ab

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_021325646.1 Gene:lrp1ab / 565797 ZFINID:ZDB-GENE-030131-7126 Length:4562 Species:Danio rerio


Alignment Length:1978 Identity:638/1978 - (32%)
Similarity:981/1978 - (49%) Gaps:266/1978 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 NAPHYGIHPTNALGRWDWNKHKQLHSDARIGHLEAGNESREDQLSEELSKFGEKLFPVSNYPPYQ 96
            |.|....|..|.|   .||:::            .|...:.||.:::.:....:..|:     |:
Zfish   750 NHPFGLCHHKNFL---FWNEYR------------GGGIYKLDQNTKKATLLRNERPPI-----YE 794

  Fly    97 QNNEDSQEVHHSGEGRLHTMESSVPSKTRISGGTNSND--TPKFRNIGAQRGRTEIAGIRETDRI 159
            ....|:|:....|        |:|....  :||.:|..  ||..|:......:     |.:||..
Zfish   795 IRTYDAQQQQIIG--------SNVCRAN--NGGCSSLCLLTPTGRSCACADDQ-----ILDTDNK 844

  Fly   160 SSRGRDGFIGGPSNKQKPFRVNLAVLVQDDPSQPGETYSNCQNSN--------ESDENCNPEEDA 216
            :.|....::..|.                  .||||  ..|:|:.        :.|.:|....|.
Zfish   845 TCRANPSYVPPPQ------------------CQPGE--FACKNNRCIQERWKCDGDNDCLDNSDE 889

  Fly   217 VPNLQRDCEKTGIHVMCP------RTFRCISKYWLCDGDDDCGDYSDETH--CGARTNCTDDQFE 273
            .|:|   |.:   |. ||      :..|||...||||||:|||:..||::  |.||| |..:|:.
Zfish   890 TPDL---CNQ---HT-CPADRFKCQNNRCIPLRWLCDGDNDCGNDEDESNSTCLART-CPSNQYP 946

  Fly   274 CLNGFCIPRTWVCDGENDCKDFSDE-THCNRTTCTD-EHFTCNDGYCISLAFRCDGEHDCNDNSD 336
            |.:|.|||.:|:||.::||.|.||| ..|...||.. ..|||.:|.||::.:|||.::||.||||
Zfish   947 CASGRCIPVSWMCDLDDDCGDRSDEPASCAYPTCYPLTQFTCANGRCINVNWRCDNDNDCGDNSD 1011

  Fly   337 ELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDE--ENCPQK----PS 395
            |..|:   :||...:|||.         ||:||...:.|||||||||:|||  .||..:    |.
Zfish  1012 EAGCS---HSCSSVQFKCN---------SGRCIPEYWTCDGDNDCGDYSDETHANCTNQATRPPG 1064

  Fly   396 LCTSNEYKC-ADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCG-SDEFTC-NNGRCILK 457
            .|.::|::| .||.|||.||:||.:.||....||.:|.  |..|  .|. :.:|.| ::.|||.|
Zfish  1065 GCHTDEFQCRMDGLCIPMRWRCDGDTDCMDLSDEKNCE--GVTH--MCDPAVKFACKDSARCISK 1125

  Fly   458 TWLCDGYPDCAAGEDEVECH-LQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADC 521
            .|:||...||....||..|. |:|.|...:|     .:|..||:..:.:|||.::||...||..|
Zfish  1126 AWVCDRDSDCEDNSDEENCEALECKLSHHVC-----ASNDSICLPPEKLCDGKDDCPDASDEKLC 1185

  Fly   522 PKERKCS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDEC-QYLTSPVCSQKCHNTM 584
               ..|: |...|...|.........|:|..|..:..:...|.....| ::|.   |||:|....
Zfish  1186 ---NLCTVENGGCSHNCTIAPGEGVLCSCPAGMELGTDNKTCQIQSFCAKHLK---CSQRCVQEK 1244

  Fly   585 GSFKCSCETGYILRPDLRSCKALGGAMTLLV-ANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHH 648
            .:.||:|..|:.|.||..|||:.......:: :||.:|||:.|....:|.:|.||.|.||||||.
Zfish  1245 ATVKCACYEGWALGPDGESCKSTDPFKPFIIFSNRHEIRRIDLYKGEFSVLVPGLRNTIALDFHF 1309

  Fly   649 RKGLMFWSDVSTDVI--KMVYMNG--TRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVS 709
            .:..::|:||..|.|  ..:..||  |....||::||.:|.|:|||||...::|.:|...::||:
Zfish  1310 NQSSLYWTDVVEDKIYRGKLSENGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVA 1374

  Fly   710 NFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDW-GPNPKIERAYMDGTQRKVIISK-GV-TWP 771
            ...|.:||.:.:.:::.||||.:.|.:.:.||:|| ..:|:||.|.|.|..|:.|..: |: .||
Zfish  1375 KLDGTMRTTLLAGEVEHPRAIALDPRDGILFWTDWDASSPRIEAASMSGEGRRTIHKETGIGGWP 1439

  Fly   772 NGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTKTV 834
            |||.:|:...:|.|.||:..||..:..|||...::|  ..||.||||:||:...:|||||.|.|:
Zfish  1440 NGLTVDYLERRILWIDARSDAIYSAAYDGSGLIEVLRGHEHLSHPFAVTLYGGEVYWTDWRTNTL 1504

  Fly   835 SAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPN-KTSRRCG 898
            :.|:|.||.....|......|.|:..:||:|||:..:.|..:..  :|.||||||.| ..:..|.
Zfish  1505 ARANKWTGHNVTVVQRTNTQPFDLQVFHPSRQPQAPNPCAANDG--KGPCSHLCLINYNQTFSCA 1567

  Fly   899 CPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVP-LDNLKHAVALDWCS 962
            ||..:.||.|..||.... :.:|.||:.:||...: ||......:...|| :||:   ..:|:.:
Zfish  1568 CPHLMKLKADKHTCYEYR-QFLLYARQIEIRGVDI-DNPYYNYIISFTVPDIDNV---TVVDYDA 1627

  Fly   963 DTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNR--IEVATT 1025
            ....|||:||...||.:|.:||:..:.||.::|.:..|||:|||:..|:||...||:  |.||..
Zfish  1628 LEHRIYWSDVRTQTIKRAFINGTGVETVVSADLPNAQGLAVDWISRNLFWTSYDTNKKQINVARL 1692

  Fly  1026 NGKMRTLLI-WEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPN--- 1086
            :|..:..:| .:.|.||..:|::||.|.::|.| ||:  |..|||||      |:..|::.|   
Zfish  1693 DGSFKNAVIHGQGLDKPHCLVLHPILGKLYWLD-GDN--ISMANMDG------TNHTLLFTNQKG 1748

  Fly  1087 --GLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVI--LNG-LGHPFGLDVNEGRVFWTDWDTKS 1146
              ||:||::..::|::.....|:.:...||||.:||  :.| |.....|.:...:::|.|..|..
Zfish  1749 PVGLSIDFDSEQLYWISSRNSTINHCKMDGSGLEVIESVKGKLTKATALAIMGDKLWWADQSTDQ 1813

  Fly  1147 VMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRI-FNACDKLNGGCSHLCL-LNPTSYTCACTV 1209
            :.:.:|..|.:..|:..:::.:|.:::::.:..:| .|.|.|.||.||.||| .:|::..|.||.
Zfish  1814 IGTCDKSDGGNWKVLRYHTSPMMHMKIYNESVHQIGTNLCSKNNGDCSQLCLPTSPSTRACMCTA 1878

  Fly  1210 GVQLKEDRHTCSEGPTQYILFAHRIDIRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWS 1274
            |..||..:.:| ||...::|::....||.|.||.....|.::|:...|.||.:|.......|||.
Zfish  1879 GYSLKSGQQSC-EGMGSFLLYSVHEGIRGIPLDPSDKSDALVPVSGTSLAVGIDFHADNDTIYWV 1942

  Fly  1275 DTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAY 1339
            |...:.|..:..|....:.||.:.:...:|:.||.|...|||.|.|...||||.|:||.|:|:..
Zfish  1943 DMGLSTISRAKRDQTWREDIVTNGIGRVEGITVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVIS 2007

  Fly  1340 KDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWV 1404
            ..|:.||.:|:..|.|.||||:||.|.:||||.|||:||..:|..::.||||:|:|.:...:||.
Zfish  2008 HGLDKPRAIAVHPEKGYLFWTEWGQYPRIERSRLDGSERVVLVNVSISWPNGISIDYQEGLLYWC 2072

  Fly  1405 DARLKTIDSCDY-TGNQRKLIMSSLH-HPYALALSDDNIYWTDWKSKALHMTERRNISAKRDIIT 1467
            |||...|:..:. ||..|:|::||.: ..:|:::.:|.|||:| ::.|....:|.|.....|::.
Zfish  2073 DARTDKIERINLETGENRELVLSSNNMDMFAVSVFEDYIYWSD-RTHANGSIKRGNKDNATDMVY 2136

  Fly  1468 NIDG----LMDIKIIYQNQNQSTMKNACGNNNGNCSHLCL-RNPSGYSCQCPIGLRLRQNSTTQC 1527
            ...|    |.|||:..:.:.|.|  |.|..|||.|..||| |.....:|.|..|:......:  |
Zfish  2137 LRTGIGVQLKDIKVFNRARQQGT--NVCKVNNGGCEQLCLFRGNGNRTCACAHGMLAEDGHS--C 2197

  Fly  1528 QNLPEDYLLIALRSGIGMISLNSGDFMDVVLPI------NGVHGAVVLDYHYR------KNLLFF 1580
            ::. :.|||.:.|:.:..|.|:  |..::..||      ..:...:.|.:.||      .|.:|:
Zfish  2198 RDY-DGYLLYSERTILKSIHLS--DETNLNAPIKPFEDPEHMKNVIALTFDYRGGGGKGANRIFY 2259

  Fly  1581 ADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGIAVDWIADNLYW-----SDTDRKLIEVSRLDGS 1640
            :|::...|:.:| .:.::.|.|| .:|.:..|:|.....|.|||     |...|..::.|| .|:
Zfish  2260 SDIHFGNIQHIN-DDGSDRKTIV-DNVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQSR-SGA 2321

  Fly  1641 CRKRIVEDNLGD--PRSLIVHPKKAYLFWSDWS--SPAKIERSYLDGSNRTVIITSGIGFPTGLT 1701
            ..:..|....||  ||:.::...:..:||::|:  ||: |.|:.|.|:|..|||.:.|..|.||.
Zfish  2322 FDRDTVVTMSGDDHPRAFVLDECQDLMFWTNWNEQSPS-IMRASLSGANVLVIIGNNIRTPNGLA 2385

  Fly  1702 IDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAP-HPFGLTLFENSIFWTDWYNKSVYRSQKL 1765
            ||....:|.::||..|.|.:.:::|.||..::...| |||||.::.:.||||||..::|.|:.| 
Zfish  2386 IDHRAEKLYFSDATFDKIERCEYDGSRRFVVLKNEPVHPFGLAVYGDYIFWTDWVRRAVLRADK- 2449

  Fly  1766 ARSGYGNPFEV--RDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTHLCLNRN------------ 1816
                ||...:|  .|.....:.|.||:........:.|..:||||..|||..:            
Zfish  2450 ----YGRDMKVLRADIPQQPMGIIAVAKDTNSCEFSPCLTNNGGCQDLCLITSEGRVNCSCRGER 2510

  Fly  1817 ----------------------------VDY------VCACPDVMDPKDVACSIKPKVLVHANLE 1847
                                        :||      :..|.|..|.|...|:.:.....:....
Zfish  2511 KLLGDNTCVAENTTCNSVDEFECGNGDCIDYSLTCDSLAHCKDKSDEKQAYCANRMCKKGYRRCI 2575

  Fly  1848 NDQLLEYSD--ESTDDSTPPELLGESND 1873
            |.:.:::|.  :||||      .|:.:|
Zfish  2576 NGRCIKHSSWCDSTDD------CGDGSD 2597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 16/34 (47%)
LDLa 306..340 CDD:238060 17/34 (50%)
LDLa 347..390 CDD:238060 20/44 (45%)
LDLa 397..431 CDD:238060 16/34 (47%)
LDLa 442..476 CDD:238060 14/35 (40%)
LDLa 480..521 CDD:238060 13/40 (33%)
FXa_inhibition 576..604 CDD:291342 11/27 (41%)
LY 634..671 CDD:214531 17/40 (43%)
NHL <656..793 CDD:302697 53/143 (37%)
LY 680..714 CDD:214531 13/33 (39%)
NHL repeat 681..722 CDD:271320 15/40 (38%)
NHL repeat 726..760 CDD:271320 15/34 (44%)
LY 761..803 CDD:214531 17/43 (40%)
NHL repeat 769..793 CDD:271320 10/23 (43%)
FXa_inhibition 882..912 CDD:291342 14/30 (47%)
LY 946..985 CDD:214531 14/39 (36%)
NHL <967..1142 CDD:302697 65/185 (35%)
LY 988..1030 CDD:214531 18/43 (42%)
NHL repeat 998..1037 CDD:271320 16/41 (39%)
NHL repeat 1038..1080 CDD:271320 18/41 (44%)
NHL repeat 1084..1119 CDD:271320 11/39 (28%)
FXa_inhibition 1185..1220 CDD:291342 16/35 (46%)
NHL 1260..>1445 CDD:302697 74/186 (40%)
NHL repeat 1260..1296 CDD:271320 9/35 (26%)
NHL repeat 1302..1337 CDD:271320 17/34 (50%)
NHL repeat 1345..1383 CDD:271320 21/37 (57%)
FXa_inhibition <1499..1525 CDD:291342 7/26 (27%)
LY 1600..1640 CDD:214531 14/44 (32%)
LY 1643..1686 CDD:214531 14/46 (30%)
LY 1688..1729 CDD:214531 15/40 (38%)
FXa_inhibition 1801..>1825 CDD:291342 11/69 (16%)
lrp1abXP_021325646.1 LDLa 36..69 CDD:197566
LDLa 81..114 CDD:197566
FXa_inhibition 170..198 CDD:317114
NHL <292..479 CDD:302697
NHL repeat 292..325 CDD:271320
LY 323..365 CDD:214531
NHL repeat 332..368 CDD:271320
LY 368..408 CDD:214531
NHL repeat 373..413 CDD:271320
NHL repeat 421..467 CDD:271320
FXa_inhibition 494..526 CDD:317114
LY 558..600 CDD:214531
LY 602..640 CDD:214531
LY 647..695 CDD:214531
LY <707..740 CDD:214531
FXa_inhibition 811..846 CDD:317114 9/41 (22%)
LDLa 857..889 CDD:197566 8/51 (16%)
LDLa 899..932 CDD:238060 16/32 (50%)
LDLa 940..971 CDD:238060 14/30 (47%)
LDLa 982..1015 CDD:238060 16/32 (50%)
LDLa 1019..1052 CDD:238060 20/41 (49%)
LDLa 1066..1101 CDD:238060 16/34 (47%)
LDLa 1110..1144 CDD:238060 13/33 (39%)
LDLa 1149..1185 CDD:238060 13/40 (33%)
FXa_inhibition 1188..1224 CDD:317114 7/35 (20%)
LY 1339..1381 CDD:214531 16/41 (39%)
LY 1383..1426 CDD:214531 15/42 (36%)
LY 1437..1470 CDD:214531 14/32 (44%)
LY 1479..1515 CDD:214531 19/35 (54%)
LY 1616..1652 CDD:214531 13/38 (34%)
LY 1653..1696 CDD:214531 18/42 (43%)
LY 1700..1739 CDD:214531 19/47 (40%)
LY 1739..1780 CDD:214531 10/40 (25%)
FXa_inhibition 1853..1889 CDD:317114 16/35 (46%)
LY 1919..1959 CDD:214531 11/39 (28%)
LY 1962..2002 CDD:214531 18/39 (46%)
LY 2003..2046 CDD:214531 21/42 (50%)
LY 2048..2090 CDD:214531 15/41 (37%)
FXa_inhibition 2162..2197 CDD:317114 12/36 (33%)
SGL 2236..2464 CDD:331563 74/236 (31%)
Ldl_recept_b 2346..2387 CDD:278487 17/41 (41%)
LY 2372..2413 CDD:214531 15/40 (38%)
FXa_inhibition 2483..2518 CDD:317114 8/34 (24%)
LDLa 2523..2559 CDD:294076 5/35 (14%)
LDLa 2567..2601 CDD:238060 8/37 (22%)
LDLa 2606..2640 CDD:238060
LDLa <2667..2689 CDD:238060
LDLa 2697..2731 CDD:238060
LDLa 2738..2769 CDD:197566
LDLa 2777..2810 CDD:197566
LDLa 2821..2853 CDD:197566
Ldl_recept_a 2861..2895 CDD:278486
LDLa 2908..2942 CDD:238060
cEGF 2965..2988 CDD:315355
EGF_CA 2985..3019 CDD:214542
LY 3052..3096 CDD:214531
LY 3097..3139 CDD:214531
LY 3141..3183 CDD:214531
LY 3184..3226 CDD:214531
LY 3227..3267 CDD:214531
FXa_inhibition 3297..3333 CDD:317114
LDLa 3337..3368 CDD:238060
LDLa 3377..3411 CDD:238060
LDLa 3416..3451 CDD:238060
LDLa 3455..3488 CDD:197566
LDLa 3496..3529 CDD:197566
LDLa 3539..3573 CDD:238060
LDLa 3578..3612 CDD:238060
LDLa 3616..3650 CDD:238060
LDLa 3658..3690 CDD:238060
LDLa 3699..3735 CDD:238060
LDLa 3741..3776 CDD:238060
EGF_CA 3825..3855 CDD:214542
LY 3963..3999 CDD:214531
Ldl_recept_b 4020..4060 CDD:278487
LY 4044..4085 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - O PTHR24270
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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