DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp1ba

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_021325253.1 Gene:lrp1ba / 565136 ZFINID:ZDB-GENE-050208-608 Length:4654 Species:Danio rerio


Alignment Length:2042 Identity:655/2042 - (32%)
Similarity:977/2042 - (47%) Gaps:309/2042 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KTAVKRNAPH---YGIHPTNALGRW-DWNK------------------HKQL------------- 55
            :|.::.|..|   ..:.|.|....| ||.:                  |:|:             
Zfish   640 RTLLEGNMSHPRAIVVDPLNGWMYWTDWEEDELIDSRGRIEKAWMDGSHRQIFVTSNMLWPNGLT 704

  Fly    56 --HS-------DARIGHLE-------------AGNE------------------------SREDQ 74
              ||       ||...|:|             :|.|                        .|.|.
Zfish   705 LDHSSSVMYWCDAYYDHIEKIYLNGSHRTVVYSGKELNHPFGIAHYQNYIFWTDYMNASIFRLDL 769

  Fly    75 LSEELSKFGEK---LFPVSNYPPYQQNNEDSQEVHHSGEGRLHTMESSVPSKTRISGGTNSNDTP 136
            ||:::|....:   ||.:..|.|..|...:...|:|.|         ..||...::       ||
Zfish   770 LSDDVSLLRAERPPLFGIQVYDPQSQKGNNQCSVNHGG---------CSPSALCLT-------TP 818

  Fly   137 KFRNIGAQRGRTEIAGIRETDRISSRGRDGFIGGPSNKQKPFRVNLAVLVQDDPSQPGETYSNCQ 201
            ..|......|:.:     |.|.|:       ...||...|..|.:           |.|  ..||
Zfish   819 AGRVCACADGQHQ-----EKDNIT-------CSSPSEVTKIKRCS-----------PAE--FQCQ 858

  Fly   202 NSN--------ESDENCNPEEDAVPNLQRDCEKTGIHVMCPR------TFRCISKYWLCDGDDDC 252
            |..        :.|::|:...|..|.|   |...    :||.      ..|||.|.|||||.|||
Zfish   859 NQRCIQISWKCDGDDDCSDGSDEDPLL---CSNR----ICPADQFKCLNNRCIPKRWLCDGTDDC 916

  Fly   253 GDYSDETH--CGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDE-THCNRTTCTD-EHFTC 313
            |...||::  |.|:| |...||.|.||.|||..|.||.::||.|.||| :.|:..||.. ..|.|
Zfish   917 GSNEDESNRTCSAQT-CQPGQFPCANGRCIPENWRCDRDDDCGDQSDESSSCDFPTCEPLTQFGC 980

  Fly   314 NDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGD 378
            .:|.|||:.:.||.|.||.|.|||:.|   :::|...:|:|         .||:||...:.||||
Zfish   981 TNGKCISVKWHCDSEDDCGDGSDEVGC---VHACSVAQFQC---------SSGKCIPEHWMCDGD 1033

  Fly   379 NDCGDWSDEENCPQKPSL-----CTSNEYKC-ADGTCIPKRWKCDKEQDCDGGEDENDC-GSLGS 436
            |||||.|||.....:.::     |:..|:.| .||||||:.|:||.::||:.|.||..| |:...
Zfish  1034 NDCGDLSDENATCSRTAISAINDCSEKEFHCRGDGTCIPEIWRCDGDKDCEDGSDEFACEGAKRM 1098

  Fly   437 EHPLTCGSDEFTCN-NGRCILKTWLCDGYPDCAAGEDEVECHLQ-CDLGQFLCPTKQNLTNLKIC 499
            ..|    ..:|||. :|:|:.|.|:|||..||....||..|.:. |...:|.|     ..:..:|
Zfish  1099 CDP----KAKFTCKVSGKCVSKDWVCDGDIDCEDQSDEEGCEVSVCKPPKFPC-----ANDTSVC 1154

  Fly   500 VHQKHICDGHNECPAGEDEADCPKERKCS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCT 563
            :..:.||:|..:|....||.  |...:|| ....|...|.........|:|..|:.:..:...|.
Zfish  1155 LPPERICNGWKDCADHSDEG--PYCDECSIRKGGCSHECSVAPGKGVVCSCPAGFQLGSDAQTCE 1217

  Fly   564 DIDEC-QYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVAN-RWDIRRVTL 626
            .:|.| ::|.   |||.|.....:.||||..|:.|..|..||.:.......::.: |.:|||:.|
Zfish  1218 ILDYCSKHLR---CSQVCEQHKNTVKCSCYPGWSLGSDGDSCYSTDPFEAFIIFSIRHEIRRINL 1279

  Fly   627 SNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVI---KMVYMNG-TRVRDVIKWGLESPGGI 687
            ....||.:|.||.|.||||||..:.|::|:||..|.|   |:....| :.:..|::.||.:|.|:
Zfish  1280 HKGDYSLLVPGLRNTIALDFHFSQSLLYWTDVVEDKIYRGKLSEGGGVSAIEVVVQHGLATPEGL 1344

  Fly   688 AVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPN-PKIE 751
            |||||...|:|.||...::|||...|.|||.:.:..::.||||.|.||:...||:||... |:||
Zfish  1345 AVDWIAGNLYWIDSNLDQIEVSKLNGELRTTLIAGGMEHPRAIAVDPGQGALFWTDWDATFPRIE 1409

  Fly   752 RAYMDGTQRKVIISKGVT--WPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTH--LP 812
            .|.|.|.||.|:.....|  |||||.:|...|:|.|.||:..||..:..||:...:||..|  |.
Zfish  1410 GASMSGKQRHVVFKDMDTGAWPNGLTLDHMESRIIWTDARSDAIYSALYDGTGVIEILRGHEFLS 1474

  Fly   813 HPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDR 877
            ||||::||...:|||||.|.|::.|:|.||.....:.:....|.|:..|||:|||:....|..: 
Zfish  1475 HPFAVSLFGGNVYWTDWRTNTLTKANKWTGANVTVIQKTSAQPFDLEIYHPSRQPQTVSPCAGN- 1538

  Fly   878 RGLRGGCSHLCLPN-KTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPN 941
             |.||.||||||.| ..|..|.||..:.|..:..||:. ..:.:|.|||.:||          ..
Zfish  1539 -GGRGHCSHLCLLNYNGSASCSCPHLMKLSANNSTCQG-VKRFLLYARRSEIR----------GV 1591

  Fly   942 DVD-------MIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPV 999
            |:|       |.:.:.::....::|:.:..:.|||.||:..||.:|.:||:..|.|:..:|.:..
Zfish  1592 DIDNPYLNVIMALTVPDIDDVTSMDYDAVEERIYWADVKSRTIKRAFINGTQLQTVLSGDLSNVR 1656

  Fly  1000 GLALDWITDKLYW--TDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDP 1062
            |||:||::..:||  :|.....|.||..:|.::|.:: ..:.||:.:|::|.:|.|||.|.|   
Zfish  1657 GLAIDWLSRNMYWMSSDNDETHINVARLDGSLKTTVV-HGMDKPKSLVLHPSKGKMFWMDGG--- 1717

  Fly  1063 MIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVI---LNGL 1124
            .|..||||| ..:.|..:....|.||:||:..:|:|::..|..|:...|.||||..||   .:.|
Zfish  1718 TINMANMDG-SNIKILHQNQKEPVGLSIDFSSNKLYWISSGNGTINRCNLDGSGLDVIDSMKSQL 1781

  Fly  1125 GHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLN 1189
            .....|.|..|:::|.|.....:.:.||..||:..|:...:|.|:.|:|:.:..::..|.|...|
Zfish  1782 RKATALAVMGGKLWWADDVLAQLGTVNKRDGKNLTVLRNKTTGLVHIKVYDKDTQKGRNPCVLNN 1846

  Fly  1190 GGCSHLCLLNPTS---YTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQISLDFDHLIDVVL 1251
            ||||.:||  |||   .||:||.|..|::||.|| ||...:::::....||.:|||.....:|:.
Zfish  1847 GGCSQICL--PTSEITRTCSCTTGYNLRQDRSTC-EGLQSFLMYSVNEGIRGLSLDPSDNSEVLT 1908

  Fly  1252 PLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTIYW 1316
            ||.....||.||...|...:||:|...|.|..||.|....:.|:...|...:||.||.|...|||
Zfish  1909 PLSGTLFAVGLDYHAKNDTLYWTDMGSNKISRSSRDQTWREDIITSGLGRVEGLAVDWIAGNIYW 1973

  Fly  1317 ADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRI 1381
            ||.|.:.||||.|:|..|.|:..::|:.||.:|:....|.||||:||....|.||.|||:|:|.:
Zfish  1974 ADHGLNLIEVARLNGMYRAVVISEELDQPRAIAVHPVKGFLFWTEWGQSPTISRSRLDGSEQSVL 2038

  Fly  1382 VTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDY-TGNQRKLIMSSLH-HPYALALSDDNIYWT 1444
            |:..|..|||:|:|.:..::||.|||...|:..:. .|.||:::.||.. ..:::|:....::|:
Zfish  2039 VSTGLARPNGVSIDYQENKLYWCDARNNKIERINLERGEQREIVFSSSGVDMFSIAVFGAYLFWS 2103

  Fly  1445 DWKSKALHMTERRNISAKR--DIITNIDG----LMDIKIIYQNQNQSTMKNACGNNNGNCSHLC- 1502
            |   :|......|..|.|.  |::|...|    |.|:|:..|::.:.|  |||..:||.|..|| 
Zfish  2104 D---RAYANGSIRRASKKDAVDVVTIRSGLSVSLKDVKVFNQDREKGT--NACSKSNGGCQQLCF 2163

  Fly  1503 -LRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPI----NG 1562
             |.| :..:|.|..|. |.|:. .:|... |.|||.:.|:.:..|.|:  |..|:..||    |.
Zfish  2164 YLGN-NRKTCACAHGY-LAQDG-LRCIRY-EGYLLYSERTVLRTIHLS--DENDLNSPIRAYENP 2222

  Fly  1563 VH--GAVVLDYHYRKNL-----LFFADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGIAVDWIAD 1620
            |:  ..:.|.:.:|:|.     :||:||:...|:.:|  :....:.|:..:|.:..|:|.....|
Zfish  2223 VYFKNIIALAFDHRQNAHGTNRIFFSDVHYGNIQVIN--DDWTGRRIIAENVGSVEGLAYHRGWD 2285

  Fly  1621 NLYWSDT-----DRKLIEVSRLDGSCRKRIV----EDNLGDPRSLIVHPKKAYLFWSDWSSP-AK 1675
            .|||:.:     .|..|:.||.:...|..:|    ||:   |..|.:...:..:||::|:.. ..
Zfish  2286 VLYWTSSTTASITRHHIDQSRTNAFDRDTVVSLSEEDH---PHVLTLDECQNLMFWTNWNEQHPS 2347

  Fly  1676 IERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHP- 1739
            |.||.|.|.|..:|:::.:..|.|||||....:|.::|....:|.:.||:|.:|..||...|.. 
Zfish  2348 IMRSTLTGRNIRIIVSTDVITPNGLTIDHKAEKLYFSDGSLGHIERCDFDGSQRYVIVKSGPGTF 2412

  Fly  1740 FGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQPKSVNHCAQD 1804
            |||.::.:.|||:||..::|.||.|.  :|........|.....:.|.|||........:.|:.:
Zfish  2413 FGLAIYRDFIFWSDWTRRAVIRSDKF--TGANTKVLRSDIPHQPMGIIAVSNDTNSCEASPCSVN 2475

  Fly  1805 NGGCTHLCLNRNVDYV-CACPD---VMDPKDVAC-SIKPKVLVHANLE--NDQLLEYSDESTDDS 1862
            ||||..|||...:..| |:|..   ::|  |..| |......:|:..:  |.:.::|        
Zfish  2476 NGGCHDLCLLTPLGVVNCSCRGERILLD--DNRCVSPNSSCNIHSEFQCGNGECIDY-------- 2530

  Fly  1863 TPPELLGESNDHGDDGHTKKSDQEREF 1889
               :|..:...|..|    :||::.::
Zfish  2531 ---QLTCDGIAHCKD----RSDEKMQY 2550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 18/34 (53%)
LDLa 306..340 CDD:238060 16/34 (47%)
LDLa 347..390 CDD:238060 19/42 (45%)
LDLa 397..431 CDD:238060 17/34 (50%)
LDLa 442..476 CDD:238060 14/34 (41%)
LDLa 480..521 CDD:238060 10/40 (25%)
FXa_inhibition 576..604 CDD:291342 11/27 (41%)
LY 634..671 CDD:214531 18/40 (45%)
NHL <656..793 CDD:302697 59/143 (41%)
LY 680..714 CDD:214531 16/33 (48%)
NHL repeat 681..722 CDD:271320 19/40 (48%)
NHL repeat 726..760 CDD:271320 17/34 (50%)
LY 761..803 CDD:214531 17/43 (40%)
NHL repeat 769..793 CDD:271320 12/25 (48%)
FXa_inhibition 882..912 CDD:291342 13/30 (43%)
LY 946..985 CDD:214531 10/38 (26%)
NHL <967..1142 CDD:302697 64/179 (36%)
LY 988..1030 CDD:214531 15/43 (35%)
NHL repeat 998..1037 CDD:271320 13/40 (33%)
NHL repeat 1038..1080 CDD:271320 17/41 (41%)
NHL repeat 1084..1119 CDD:271320 14/34 (41%)
FXa_inhibition 1185..1220 CDD:291342 19/37 (51%)
NHL 1260..>1445 CDD:302697 72/186 (39%)
NHL repeat 1260..1296 CDD:271320 13/35 (37%)
NHL repeat 1302..1337 CDD:271320 18/34 (53%)
NHL repeat 1345..1383 CDD:271320 18/37 (49%)
FXa_inhibition <1499..1525 CDD:291342 9/27 (33%)
LY 1600..1640 CDD:214531 12/44 (27%)
LY 1643..1686 CDD:214531 13/47 (28%)
LY 1688..1729 CDD:214531 13/40 (33%)
FXa_inhibition 1801..>1825 CDD:291342 11/24 (46%)
lrp1baXP_021325253.1 LDLa 30..62 CDD:197566
LDLa 74..107 CDD:197566
FXa_inhibition 163..191 CDD:317114
LY 276..309 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..519 CDD:317114
LY 553..593 CDD:214531
LY 594..633 CDD:214531
LY 640..689 CDD:214531 8/48 (17%)
LY 690..732 CDD:214531 7/41 (17%)
FXa_inhibition 801..838 CDD:317114 12/64 (19%)
LDLa 891..924 CDD:238060 17/32 (53%)
LDLa 974..1007 CDD:238060 15/32 (47%)
LDLa 1011..1042 CDD:197566 17/39 (44%)
LDLa 1057..1092 CDD:238060 17/34 (50%)
LDLa 1104..1135 CDD:238060 14/30 (47%)
LDLa 1140..1173 CDD:197566 8/37 (22%)
FXa_inhibition 1180..1216 CDD:317114 7/35 (20%)
LY 1284..1322 CDD:214531 19/37 (51%)
LY 1331..1370 CDD:214531 17/38 (45%)
LY 1375..1418 CDD:214531 17/42 (40%)
LY <1430..1463 CDD:214531 15/32 (47%)
LY 1604..1643 CDD:214531 11/38 (29%)
LY 1645..1687 CDD:214531 14/41 (34%)
LY 1689..1728 CDD:214531 17/43 (40%)
LY <1739..1770 CDD:214531 12/30 (40%)
FXa_inhibition 1842..1878 CDD:317114 19/37 (51%)
NHL 1923..>2095 CDD:302697 67/171 (39%)
NHL repeat 1923..1956 CDD:271320 10/32 (31%)
NHL repeat 1961..1996 CDD:271320 19/34 (56%)
NHL repeat 2002..2040 CDD:271320 18/37 (49%)
NHL repeat 2043..2084 CDD:271320 15/40 (38%)
FXa_inhibition 2151..2186 CDD:317114 13/37 (35%)
LY 2265..2305 CDD:214531 10/39 (26%)
Ldl_recept_b 2334..2375 CDD:278487 14/40 (35%)
LY 2359..2401 CDD:214531 13/41 (32%)
FXa_inhibition 2472..2506 CDD:317114 13/35 (37%)
LDLa 2518..2547 CDD:238060 7/43 (16%)
LDLa 2556..2590 CDD:238060
LDLa 2595..2629 CDD:238060
LDLa <2652..2681 CDD:294076
LDLa 2689..2723 CDD:238060
LDLa 2727..2758 CDD:238060
LDLa 2768..2801 CDD:238060
LDLa 2811..2843 CDD:197566
LDLa 2852..2884 CDD:197566
LDLa 2898..2932 CDD:238060
cEGF 2955..2978 CDD:315355
EGF_CA 2975..3005 CDD:214542
LY 3042..3086 CDD:214531
LY 3088..3125 CDD:214531
Ldl_recept_b 3149..3189 CDD:278487
LY 3173..3213 CDD:214531
FXa_inhibition 3284..3320 CDD:317114
LDLa 3324..3355 CDD:197566
LDLa 3364..3398 CDD:238060
LDLa 3403..3438 CDD:238060
LDLa 3443..3478 CDD:238060
LDLa 3483..3517 CDD:238060
LDLa 3522..3556 CDD:238060
LDLa 3560..3594 CDD:238060
LDLa 3608..3642 CDD:238060
LDLa 3646..3681 CDD:238060
LDLa 3688..3720 CDD:238060
LDLa 3729..3765 CDD:238060
LDLa 3775..3809 CDD:238060
Ldl_recept_b 4051..4091 CDD:278487
LY 4075..4116 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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