DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp1aa

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_021335354.1 Gene:lrp1aa / 563149 ZFINID:ZDB-GENE-030131-7889 Length:4560 Species:Danio rerio


Alignment Length:1850 Identity:605/1850 - (32%)
Similarity:941/1850 - (50%) Gaps:218/1850 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 DSQEVHHS---------------GEGRLHTMESSVPSKTRISGGTNSNDTPKF---------RNI 141
            |.||::|:               ..|.::.::.:..:.|.:     .|:.|..         :.:
Zfish   748 DGQELNHAFGLCHYKHFLFWNEYRSGSIYKLDQNTKTVTLL-----RNERPPIFEIRMYDAQQQL 807

  Fly   142 GAQRGRTEIAGIRE------TDRISSRGRDGFIGGPSN---KQKPFRVNLAVLVQDDPSQPGETY 197
            |:...|:...|...      |.|..:...|..:....|   |..|      ..:.....||||  
Zfish   808 GSNACRSNNGGCSSLCLATPTGRSCACAEDQLLDPADNTSCKANP------SYIPPPQCQPGE-- 864

  Fly   198 SNCQNSNESDE--NCNPEEDAVPNLQRDCEKTGIHVMCP------RTFRCISKYWLCDGDDDCGD 254
            ..|:|:....|  .|:.:.|.:.|.....|....|. ||      :..|||...||||||:|||:
Zfish   865 FACKNNRCIQERWKCDGDNDCLDNSDETAELCHQHT-CPADRFKCQNNRCIPMRWLCDGDNDCGN 928

  Fly   255 YSDE--THCGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDE-THCNRTTCTD-EHFTCND 315
            ..||  |.|.||| |..:|:.|.:|.|||.:|.||.::||.|.||| :.|...||.. ..||||:
Zfish   929 DEDESNTTCSART-CPPNQYSCDSGRCIPISWTCDLDDDCGDRSDEPSTCAYPTCFPLTQFTCNN 992

  Fly   316 GYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDND 380
            |.||::.:|||.::||.|||||..|:   :||...:|||.         ||:||.:.:.||||||
Zfish   993 GRCININWRCDNDNDCGDNSDEAGCS---HSCSSAQFKCN---------SGRCIPDYWTCDGDND 1045

  Fly   381 CGDWSDE--ENCPQK----PSLCTSNEYKC-ADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEH 438
            |||:|||  .||..:    |..|.::|::| .||.|||.||:||.:.||....||.:|.  |..|
Zfish  1046 CGDYSDETHANCTNQATRPPGGCHTDEFQCRMDGLCIPLRWRCDGDTDCMDLSDEKNCE--GVTH 1108

  Fly   439 PLTCG-SDEFTC-NNGRCILKTWLCDGYPDCAAGEDEVECH-LQCDLGQFLCPTKQNLTNLKICV 500
              .|. :.:|.| ::.|||.|.|:|||..||....||..|. |.|.|...:|....|     ||:
Zfish  1109 --MCDPAVKFGCRDSARCISKAWVCDGDSDCEDNSDEDNCEALVCKLSHHVCANDSN-----ICL 1166

  Fly   501 HQKHICDGHNECPAGEDEADCPKERKCS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTD 564
            ..:.:|||.::||.|.||..|.   .|| |...|...|.........|:|.||..:..|...|..
Zfish  1167 PAEKLCDGKDDCPDGSDEKLCD---LCSLENGGCSHNCTVAPGEGVLCSCPLGMELGTNNKTCQI 1228

  Fly   565 IDEC-QYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLV-ANRWDIRRVTLS 627
            ...| ::|.   |||:|.....:.||||..|:.|.||:.||::.......:: :||.:|||:.|.
Zfish  1229 QGFCAKHLK---CSQRCEQDKFNVKCSCYEGWALEPDMESCRSTDPFKPFIIFSNRHEIRRIDLH 1290

  Fly   628 NNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVI--KMVYMNG--TRVRDVIKWGLESPGGIA 688
            ...:|.:|.||.|.||||||..:..::|:||..|.|  ..:..||  |....||::||.:|.|:|
Zfish  1291 KGEFSVLVPGLRNTIALDFHLNESSLYWTDVVEDKIYRGKLSENGALTSFDVVIQYGLATPEGLA 1355

  Fly   689 VDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPN-PKIER 752
            ||||...::|.:|...::||:...|.:||.:.:.|::.||||.:.|.|.:.||:||..: |:||.
Zfish  1356 VDWIAGNIYWVESNLDQIEVAKLDGTMRTTLLAGDVEHPRAIALDPREGILFWTDWDASMPRIEA 1420

  Fly   753 AYMDGTQRKVIISKGVT--WPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTH--LPH 813
            |.|.|..|:.|..:..:  |||||.:|:...:|.|.||:..||..:..|||...::|..|  |.|
Zfish  1421 ASMSGHGRRTIHKETGSGGWPNGLTVDYLERRILWIDARSDAIYSAKYDGSGLIEVLRGHEYLSH 1485

  Fly   814 PFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRR 878
            |||:|::...:|||||.|.|::.|:|.||.....|......|.|:..|||:|||:..:.|.  .|
Zfish  1486 PFAVTMYGGEVYWTDWRTNTLAKANKWTGNNVTVVQRTNTQPFDLQVYHPSRQPQAPNPCA--AR 1548

  Fly   879 GLRGGCSHLCLPN-KTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPND 942
            |..|.||||||.| ..:..|.||..:.|:||..||..:. :.:|.||:.:||            .
Zfish  1549 GGLGPCSHLCLINYNQTFSCACPHLMRLREDNHTCYESR-QFLLYARQIEIR------------G 1600

  Fly   943 VDMIVPLDN---------LKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSP 998
            ||:..|..|         :.:...:|:.:....|||:||...||.:|.:||:..:.||.:::.:.
Zfish  1601 VDIHNPYYNYIISFTVPDIDNVTVVDYDALERRIYWSDVRTQTIKRAFINGTGIETVVSADIPNA 1665

  Fly   999 VGLALDWITDKLYWT--DPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDD 1061
            .|||:||::..|:||  |.:..:|.||..:|..:..:| :.|.||..:|::|:.|.::|:| ||:
Zfish  1666 HGLAVDWVSRNLFWTSYDGNKKQINVARLDGSFKNAVI-QGLDKPHCLVLHPVLGKLYWTD-GDN 1728

  Fly  1062 PMIERANMDG-HERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVI--LNG 1123
              |..||.|| ::.:..|::|.  |.||:||::...:|:|..|..|:.....||||.:|:  :.|
Zfish  1729 --ISMANTDGTNQTMIFTNQKT--PVGLSIDFDAEHLYWVSSGNSTINRCKLDGSGLEVLDSVKG 1789

  Fly  1124 -LGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDK 1187
             |.....|.:...:::|.|..|..:.:.:|..|.:..|:..:::.::.:::::.|.:...|.|.|
Zfish  1790 KLNKASALAIMGDKLWWADQGTDQIGTCDKSDGGNWKVLRNSTSGMIHMKIYNETVQTGSNLCSK 1854

  Fly  1188 LNGGCSHLCLLNPTSY---TCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQISLDFDHLIDV 1249
            .||.||.|||  |||.   :|.||.|..|:..:.:| ||...::|::....||.|.||.....|.
Zfish  1855 NNGDCSQLCL--PTSQSSRSCMCTAGYSLRSGQQSC-EGVGSFLLYSVHEGIRGIPLDPADKSDA 1916

  Fly  1250 VLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTI 1314
            ::|:...|.||.:|.......|||.|...:.|..:..|....:.|:.:.:...:|:.||.|...|
Zfish  1917 LVPVSGTSLAVGIDFHADNDTIYWVDMGLSTISRAKRDQTWREDIITNGIGRVEGIAVDWIAGNI 1981

  Fly  1315 YWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERS 1379
            ||.|.|...||||.|:||.|:|:..:.|:.||.:.:..|.|.||||:||.|.:||||.|||:.|:
Zfish  1982 YWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPERGYLFWTEWGQYPRIERSRLDGSGRA 2046

  Fly  1380 RIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDY-TGNQRKLIMSSLH-HPYALALSDDNIY 1442
            .:|..::.||||:|:|.:...:||.|||...|:..:. ||..|::::||.: ..:::::.::.||
Zfish  2047 VLVNVSISWPNGISIDYQDGLLYWCDARTDKIERINLETGENREVVLSSNNMDMFSVSVFENYIY 2111

  Fly  1443 WTD--WKSKALHMTERRNISAKRDIITNID-GLMDIKIIYQNQNQSTMKNACGNNNGNCSHLCLR 1504
            |:|  ..:.::....:.|.:....:.|.|. .|.|||:..:.:.|.|  |.|..|||.|..|||.
Zfish  2112 WSDRTHANGSIKRGSKDNSTESVSLRTGIGVQLKDIKVFNRARQQGT--NICKINNGGCQQLCLY 2174

  Fly  1505 NPSGY-SCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPI------NG 1562
            ..:|. :|.|..|:......:  |::. :.|||.:.|:.:..:.|:  |..::..||      ..
Zfish  2175 RGNGQRTCACAHGMLAEDGQS--CRDY-DGYLLYSERTILKSVHLS--DENNLNAPIKPFEDPEH 2234

  Fly  1563 VHGAVVLDYHYR------KNLLFFADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGIAVDWIADN 1621
            :...:.|.:.||      .|.:|::|::...|:::| .:.::.|.:| .:|.:..|:|.....|.
Zfish  2235 MKNVIALTFDYRGGGGKGANRIFYSDIHFGNIQQIN-DDGSDRKTVV-ENVGSVEGLAYHRAWDT 2297

  Fly  1622 LYW-----SDTDRKLIEVSRLDGSCRKRIVEDNLGD--PRSLIVHPKKAYLFWSDWS--SPAKIE 1677
            |||     |...|..::.||.....|..:|..: ||  ||:.::...:..:||::|:  ||: |.
Zfish  2298 LYWTSYTTSTISRHTVDQSRWGAFDRDTVVTMS-GDDHPRAFVLDECQNLMFWTNWNEQSPS-IM 2360

  Fly  1678 RSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAP-HPFG 1741
            |:.|.|||..|||.|.|..|.||.||....:|.::||..|.|.:.:::|..|..::...| ||||
Zfish  2361 RAQLSGSNVIVIIGSEIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGTHRYVVLKNEPVHPFG 2425

  Fly  1742 LTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQPKSV-------- 1798
            |.::.:.||||||..::|.|:.|.              :.|.:.:....:.:||..:        
Zfish  2426 LAVYGDHIFWTDWVRRAVLRADKY--------------VGGEMKVLRADIPQQPMGIVAVANDTN 2476

  Fly  1799 ----NHCAQDNGGCTHLCLNRNVDYV-CAC 1823
                :.|..:||||..|||..:...| |:|
Zfish  2477 SCEFSPCRVNNGGCQDLCLLTSDGRVNCSC 2506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 16/34 (47%)
LDLa 306..340 CDD:238060 18/34 (53%)
LDLa 347..390 CDD:238060 20/44 (45%)
LDLa 397..431 CDD:238060 16/34 (47%)
LDLa 442..476 CDD:238060 15/35 (43%)
LDLa 480..521 CDD:238060 14/40 (35%)
FXa_inhibition 576..604 CDD:291342 12/27 (44%)
LY 634..671 CDD:214531 17/40 (43%)
NHL <656..793 CDD:302697 54/143 (38%)
LY 680..714 CDD:214531 13/33 (39%)
NHL repeat 681..722 CDD:271320 15/40 (38%)
NHL repeat 726..760 CDD:271320 16/34 (47%)
LY 761..803 CDD:214531 16/43 (37%)
NHL repeat 769..793 CDD:271320 10/25 (40%)
FXa_inhibition 882..912 CDD:291342 14/30 (47%)
LY 946..985 CDD:214531 12/47 (26%)
NHL <967..1142 CDD:302697 61/180 (34%)
LY 988..1030 CDD:214531 15/43 (35%)
NHL repeat 998..1037 CDD:271320 14/40 (35%)
NHL repeat 1038..1080 CDD:271320 16/42 (38%)
NHL repeat 1084..1119 CDD:271320 13/34 (38%)
FXa_inhibition 1185..1220 CDD:291342 17/37 (46%)
NHL 1260..>1445 CDD:302697 68/186 (37%)
NHL repeat 1260..1296 CDD:271320 9/35 (26%)
NHL repeat 1302..1337 CDD:271320 17/34 (50%)
NHL repeat 1345..1383 CDD:271320 19/37 (51%)
FXa_inhibition <1499..1525 CDD:291342 7/26 (27%)
LY 1600..1640 CDD:214531 13/44 (30%)
LY 1643..1686 CDD:214531 15/46 (33%)
LY 1688..1729 CDD:214531 16/40 (40%)
FXa_inhibition 1801..>1825 CDD:291342 10/23 (43%)
lrp1aaXP_021335354.1 LDLa 37..70 CDD:197566
LDLa 82..115 CDD:197566
FXa_inhibition 171..199 CDD:317114
LY 281..324 CDD:214531
LY 326..368 CDD:214531
LY 371..411 CDD:214531
FXa_inhibition 497..529 CDD:317114
LY 561..603 CDD:214531
LY 605..643 CDD:214531
LY 650..699 CDD:214531
LY <710..743 CDD:214531
FXa_inhibition 812..848 CDD:317114 6/35 (17%)
LDLa 859..891 CDD:197566 10/33 (30%)
LDLa 901..934 CDD:238060 16/32 (50%)
LDLa 941..973 CDD:197566 15/32 (47%)
LDLa 984..1017 CDD:238060 17/32 (53%)
LDLa 1021..1052 CDD:197566 18/39 (46%)
LDLa 1068..1103 CDD:238060 16/34 (47%)
LDLa 1112..1146 CDD:238060 14/33 (42%)
LDLa 1151..1187 CDD:238060 14/40 (35%)
FXa_inhibition 1190..1226 CDD:317114 10/35 (29%)
LY 1342..1383 CDD:214531 16/40 (40%)
LY 1385..1428 CDD:214531 17/42 (40%)
LY 1429..1472 CDD:214531 15/42 (36%)
LY 1618..1653 CDD:214531 11/34 (32%)
LY 1655..1698 CDD:214531 15/42 (36%)
LY 1702..1738 CDD:214531 16/39 (41%)
LY <1749..1780 CDD:214531 11/30 (37%)
FXa_inhibition 1852..1888 CDD:317114 17/37 (46%)
LY 1918..1958 CDD:214531 11/39 (28%)
LY 1961..2001 CDD:214531 17/39 (44%)
LY 2002..2045 CDD:214531 20/42 (48%)
LY 2047..2089 CDD:214531 15/41 (37%)
FXa_inhibition 2161..2196 CDD:317114 12/36 (33%)
SGL 2235..>2439 CDD:331563 66/207 (32%)
Ldl_recept_b 2345..2386 CDD:278487 19/41 (46%)
LY 2371..2412 CDD:214531 16/40 (40%)
FXa_inhibition 2483..2518 CDD:317114 10/23 (43%)
LDLa 2530..2559 CDD:294076
LDLa 2567..2601 CDD:238060
LDLa 2606..2640 CDD:238060
LDLa <2667..2689 CDD:238060
LDLa 2697..2731 CDD:238060
LDLa 2735..2767 CDD:238060
LDLa 2774..2807 CDD:197566
LDLa 2818..2850 CDD:197566
LDLa 2859..2891 CDD:197566
LDLa 2906..2940 CDD:238060
cEGF 2963..2986 CDD:315355
EGF_CA 2983..3013 CDD:214542
LY 3050..3094 CDD:214531
LY 3095..3137 CDD:214531
LY 3139..3181 CDD:214531
LY 3183..3224 CDD:214531
LY 3225..3265 CDD:214531
FXa_inhibition 3295..3331 CDD:317114
LDLa 3335..3366 CDD:238060
LDLa 3375..3409 CDD:238060
LDLa 3414..3449 CDD:238060
LDLa 3453..3486 CDD:197566
LDLa 3494..3527 CDD:197566
LDLa 3537..3571 CDD:238060
LDLa 3576..3610 CDD:238060
LDLa 3614..3648 CDD:238060
LDLa 3656..3688 CDD:238060
LDLa 3697..3733 CDD:238060
LDLa 3741..3776 CDD:238060
LY 3957..3993 CDD:214531
Ldl_recept_b 4014..4054 CDD:278487
LY 4038..4079 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - O PTHR24270
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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