DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and lrp13

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_021327248.1 Gene:lrp13 / 562438 ZFINID:ZDB-GENE-130729-1 Length:1354 Species:Danio rerio


Alignment Length:1129 Identity:336/1129 - (29%)
Similarity:532/1129 - (47%) Gaps:138/1129 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 GETYSNCQNSNESDENCNPEEDAVPNLQRDCEKTGIH-------------------VMCPRTFRC 239
            |...:||:|.::.|::   :||.:...:   |.||.|                   .:|.....|
Zfish   143 GSDEANCENPDDDDDD---DEDLLDEKE---EMTGEHEVSQNVPATKGPLRCSIASKLCRDGTDC 201

  Fly   240 ISKYWLCDGDDDCGDYSDETHCGARTNCTDDQFECLNG-FCIPRTWVCDGENDCKDFSDETHCNR 303
            :....:|||:.||.|.|||..|..:  |...||:|.:| .||.|..:|||...|:|.|||.:|.:
Zfish   202 VMLNHVCDGELDCKDGSDEEDCPVQ--CESGQFQCAHGKKCIDRRQLCDGVPQCQDRSDELNCFK 264

  Fly   304 TTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQC 368
            ......|....:..|:..:|.|||:.||.|.|||..|..  .||...|::|         .||||
Zfish   265 PDDDCAHRCDENTRCVPESFVCDGDPDCVDGSDEANCGE--ESCSSAEWQC---------SSGQC 318

  Fly   369 ILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGS 433
            :....||||.:||.|.||||:|.:.|. |::|........|:...|.||.|.||..|.||.:|  
Zfish   319 VSLSMRCDGHSDCRDHSDEEDCAEPPP-CSTNRRCPKSHECLLDEWMCDGETDCKDGTDEKNC-- 380

  Fly   434 LGSEHPLTCGSDEFTCNN-GRCILKTWLCDGYPDCAAGEDEVEC-HLQCDLGQFLCPTKQNLTNL 496
              .|.|:.||..:|:|:: .:||.::|.|||..||..|.||..| .:.|....|.|.:.:     
Zfish   381 --KESPVQCGEYQFSCSSKTQCIPQSWRCDGSEDCRDGSDESACASVSCPPHLFQCGSSE----- 438

  Fly   497 KICVHQKHICDGHNECPAGEDEADCPKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVN 561
              ||....:|:|...|..|.||....:..||||...|.|.|..|.||: .|.||:||....:.:.
Zfish   439 --CVEFSQLCNGVTNCLDGSDEGGSCQTEKCSEQLKCAQDCHSTPAGA-RCGCRMGYKPVDDGLR 500

  Fly   562 CTDIDECQYLTSP-VCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVT 625
            |.|:|||  :..| :||.:|:||:|||:|||..||:|.||..||| :.|...||.:.:.::..:.
Zfish   501 CADVDEC--VERPNICSHRCNNTLGSFQCSCSHGYVLEPDGHSCK-ITGEPYLLASVQSEVFLLG 562

  Fly   626 LSNNRYSAIVKGLHN-AIALDFHHRKGLMFWSDVSTDVIKMVYMN----GTRVRDVIKWGLESPG 685
            |.::....::..... .::||:..:|..::|.:::||.||.:.::    ||.::.:      |..
Zfish   563 LRSSSLDILLSAEKRFVLSLDYDWQKQRVYWINLNTDTIKWLSLDQKNKGTFLKGI------SAD 621

  Fly   686 GIAVDWIHDLLFWTDSGTRRVEVSNFQGNL-----RTVIASYDLDKPRAIVVHPGEALAFWSDWG 745
            .:||||:...|:||||...::........:     |.:|...||.:.|:|.:.|.:.:.|||:.|
Zfish   622 SLAVDWVARNLYWTDSENSQINAVRLDSEIGRSTDRVMILGEDLGQLRSIALMPQKGIMFWSETG 686

  Fly   746 PNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTH 810
            ...:||||.|||:.|:|::||.:.||..|.:|..:.:|||.|.|...|..:|:||.|...:....
Zfish   687 DEAQIERAGMDGSDRRVLVSKSLRWPVSLTVDSLHQRIYWTDEKLKCIGSANIDGGDVKLLQLME 751

  Fly   811 LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQK 875
            .|.||::::|.|.:||:|....|:..|.|.|||:.:.:.:....|..:...|...|.:.::.|:.
Zfish   752 TPSPFSVSVFNDQVYWSDTKRGTIQRAHKTTGKQRQVLLKRPGQPFGLKVIHGLLQEDVSNPCES 816

  Fly   876 DRRGLRGGCSHLC-LPNKTSRRCGCPIGLSLKEDGKTCKSTAD-KLVLVARRKDIRLRHLRDNQA 938
            .      |||||| |.......|.|.....|.|||.||....| ..:|......:...:|::..:
Zfish   817 Q------GCSHLCVLAPGLKAVCKCSTQFLLDEDGLTCSKPKDSSFLLFLSPAAVTQVYLQNRHS 875

  Fly   939 DPNDVDMIVP----------LDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQR---- 989
            |      :.|          |..:.|...||.......:|.:|.::..:      |.::.:    
Zfish   876 D------VTPQKWPEHRRFDLPKMNHPNMLDLVLRDLTLYVSDTDQPLV------GLFKMKDAAL 928

  Fly   990 -------VVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVN 1047
                   .:|.:.|..  .::||||..:||:......|:|.:.:|:..::||.|.:.....|.:.
Zfish   929 VPRGKLFQLHKDSVRV--FSVDWITLNVYWSSEKLPGIQVTSPDGRFTSVLIREGVGIIESIGLE 991

  Fly  1048 PIEGFMFWSD---WGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLEN 1109
            |..|.:.:|:   .|...|:|...|:|..| |:..:..:.|..|.:..|.:::|:.|.|...:.:
Zfish   992 PPSGRLCFSNRIQEGKMSMVECVFMNGLNR-TVVWRNSVRPTSLILTDEGNRVYWADTGLAVIAS 1055

  Fly  1110 MNFDGSGRQVILNGLGHPFGLDVNEGRVFWTDWD-TKSVMSAN-KLTGKDTNVIIANSTDLMDIR 1172
            :..||||.:.|....|......||:..|:.|..| ||...|.: :.:||   :.....|::::::
Zfish  1056 VGTDGSGYKEIKTEEGLMAFTLVNKVLVWITKKDSTKCWFSEDEQRSGK---LWFEVDTEIVNLK 1117

  Fly  1173 VFHRTRRRIFNACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIR 1237
            .|.::|::..|.|...||||:.|||..|...||.|.      .|.....:|..:  |.:|..:..
Zfish  1118 AFTKSRQKGTNLCSNGNGGCNQLCLAFPGGKTCRCA------HDHRLLDDGDCR--LESHCPENS 1174

  Fly  1238 QISLDFDHLIDVVLPLPPISNAVA 1261
            :..|.    .|:.|||....|.||
Zfish  1175 KPCLS----EDMCLPLEQFCNGVA 1194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 16/34 (47%)
LDLa 306..340 CDD:238060 12/33 (36%)
LDLa 347..390 CDD:238060 18/42 (43%)
LDLa 397..431 CDD:238060 12/33 (36%)
LDLa 442..476 CDD:238060 15/34 (44%)
LDLa 480..521 CDD:238060 11/40 (28%)
FXa_inhibition 576..604 CDD:291342 16/27 (59%)
LY 634..671 CDD:214531 8/41 (20%)
NHL <656..793 CDD:302697 47/145 (32%)
LY 680..714 CDD:214531 10/33 (30%)
NHL repeat 681..722 CDD:271320 12/45 (27%)
NHL repeat 726..760 CDD:271320 14/33 (42%)
LY 761..803 CDD:214531 16/41 (39%)
NHL repeat 769..793 CDD:271320 9/23 (39%)
FXa_inhibition 882..912 CDD:291342 13/30 (43%)
LY 946..985 CDD:214531 7/48 (15%)
NHL <967..1142 CDD:302697 44/188 (23%)
LY 988..1030 CDD:214531 11/52 (21%)
NHL repeat 998..1037 CDD:271320 11/38 (29%)
NHL repeat 1038..1080 CDD:271320 11/44 (25%)
NHL repeat 1084..1119 CDD:271320 10/34 (29%)
FXa_inhibition 1185..1220 CDD:291342 13/34 (38%)
NHL 1260..>1445 CDD:302697 2/2 (100%)
NHL repeat 1260..1296 CDD:271320 2/2 (100%)
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:291342
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
lrp13XP_021327248.1 LDLa 36..71 CDD:238060
LDLa 75..110 CDD:238060
LDLa 119..149 CDD:238060 1/5 (20%)
LDLa 195..223 CDD:238060 11/27 (41%)
LDLa 227..262 CDD:238060 16/34 (47%)
LDLa 271..301 CDD:238060 12/29 (41%)
LDLa 306..340 CDD:238060 18/42 (43%)
LDLa 351..380 CDD:238060 10/28 (36%)
LDLa 387..422 CDD:238060 15/34 (44%)
LDLa 427..458 CDD:197566 9/37 (24%)
EGF_CA 503..542 CDD:311536 21/40 (53%)
PHA02142 <569..>666 CDD:333147 23/102 (23%)
LY <622..648 CDD:214531 9/25 (36%)
Ldl_recept_b 680..718 CDD:278487 18/37 (49%)
LY 702..744 CDD:214531 16/41 (39%)
LY 744..786 CDD:214531 14/41 (34%)
FXa_inhibition 818..848 CDD:317114 13/29 (45%)
LY 976..1021 CDD:214531 12/44 (27%)
FXa_inhibition 1130..1162 CDD:317114 13/37 (35%)
LDLa 1170..1202 CDD:197566 8/29 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.710

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