DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp13

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_068074315.1 Gene:lrp13 / 562438 ZFINID:ZDB-GENE-130729-1 Length:1355 Species:Danio rerio


Alignment Length:1129 Identity:335/1129 - (29%)
Similarity:531/1129 - (47%) Gaps:137/1129 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 GETYSNCQNSNESDENCNPEEDAVPNLQRDCEKTGIH-------------------VMCPRTFRC 239
            |...:||:.:.:.|:  :.:||.:...:   |.||.|                   .:|.....|
Zfish   143 GSDEANCEENPDDDD--DDDEDLLDEKE---EMTGEHEVSQNVPATKGPLRCSIASKLCRDGTDC 202

  Fly   240 ISKYWLCDGDDDCGDYSDETHCGARTNCTDDQFECLNG-FCIPRTWVCDGENDCKDFSDETHCNR 303
            :....:|||:.||.|.|||..|..:  |...||:|.:| .||.|..:|||...|:|.|||.:|.:
Zfish   203 VMLNHVCDGELDCKDGSDEEDCPVQ--CESGQFQCAHGKKCIDRRQLCDGVPQCQDRSDELNCFK 265

  Fly   304 TTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQC 368
            ......|....:..|:..:|.|||:.||.|.|||..|..  .||...|::|         .||||
Zfish   266 PDDDCAHRCDENTRCVPESFVCDGDPDCVDGSDEANCGE--ESCSSAEWQC---------SSGQC 319

  Fly   369 ILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGS 433
            :....||||.:||.|.||||:|.:.|. |::|........|:...|.||.|.||..|.||.:|  
Zfish   320 VSLSMRCDGHSDCRDHSDEEDCAEPPP-CSTNRRCPKSHECLLDEWMCDGETDCKDGTDEKNC-- 381

  Fly   434 LGSEHPLTCGSDEFTCNN-GRCILKTWLCDGYPDCAAGEDEVEC-HLQCDLGQFLCPTKQNLTNL 496
              .|.|:.||..:|:|:: .:||.::|.|||..||..|.||..| .:.|....|.|.:.:     
Zfish   382 --KESPVQCGEYQFSCSSKTQCIPQSWRCDGSEDCRDGSDESACASVSCPPHLFQCGSSE----- 439

  Fly   497 KICVHQKHICDGHNECPAGEDEADCPKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVN 561
              ||....:|:|...|..|.||....:..||||...|.|.|..|.||: .|.||:||....:.:.
Zfish   440 --CVEFSQLCNGVTNCLDGSDEGGSCQTEKCSEQLKCAQDCHSTPAGA-RCGCRMGYKPVDDGLR 501

  Fly   562 CTDIDECQYLTSP-VCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVT 625
            |.|:|||  :..| :||.:|:||:|||:|||..||:|.||..||| :.|...||.:.:.::..:.
Zfish   502 CADVDEC--VERPNICSHRCNNTLGSFQCSCSHGYVLEPDGHSCK-ITGEPYLLASVQSEVFLLG 563

  Fly   626 LSNNRYSAIVKGLHN-AIALDFHHRKGLMFWSDVSTDVIKMVYMN----GTRVRDVIKWGLESPG 685
            |.::....::..... .::||:..:|..::|.:::||.||.:.::    ||.::.:      |..
Zfish   564 LRSSSLDILLSAEKRFVLSLDYDWQKQRVYWINLNTDTIKWLSLDQKNKGTFLKGI------SAD 622

  Fly   686 GIAVDWIHDLLFWTDSGTRRVEVSNFQGNL-----RTVIASYDLDKPRAIVVHPGEALAFWSDWG 745
            .:||||:...|:||||...::........:     |.:|...||.:.|:|.:.|.:.:.|||:.|
Zfish   623 SLAVDWVARNLYWTDSENSQINAVRLDSEIGRSTDRVMILGEDLGQLRSIALMPQKGIMFWSETG 687

  Fly   746 PNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTH 810
            ...:||||.|||:.|:|::||.:.||..|.:|..:.:|||.|.|...|..:|:||.|...:....
Zfish   688 DEAQIERAGMDGSDRRVLVSKSLRWPVSLTVDSLHQRIYWTDEKLKCIGSANIDGGDVKLLQLME 752

  Fly   811 LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQK 875
            .|.||::::|.|.:||:|....|:..|.|.|||:.:.:.:....|..:...|...|.:.::.|:.
Zfish   753 TPSPFSVSVFNDQVYWSDTKRGTIQRAHKTTGKQRQVLLKRPGQPFGLKVIHGLLQEDVSNPCES 817

  Fly   876 DRRGLRGGCSHLC-LPNKTSRRCGCPIGLSLKEDGKTCKSTAD-KLVLVARRKDIRLRHLRDNQA 938
            .      |||||| |.......|.|.....|.|||.||....| ..:|......:...:|::..:
Zfish   818 Q------GCSHLCVLAPGLKAVCKCSTQFLLDEDGLTCSKPKDSSFLLFLSPAAVTQVYLQNRHS 876

  Fly   939 DPNDVDMIVP----------LDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQR---- 989
            |      :.|          |..:.|...||.......:|.:|.::..:      |.::.:    
Zfish   877 D------VTPQKWPEHRRFDLPKMNHPNMLDLVLRDLTLYVSDTDQPLV------GLFKMKDAAL 929

  Fly   990 -------VVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVN 1047
                   .:|.:.|..  .::||||..:||:......|:|.:.:|:..::||.|.:.....|.:.
Zfish   930 VPRGKLFQLHKDSVRV--FSVDWITLNVYWSSEKLPGIQVTSPDGRFTSVLIREGVGIIESIGLE 992

  Fly  1048 PIEGFMFWSD---WGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLEN 1109
            |..|.:.:|:   .|...|:|...|:|..| |:..:..:.|..|.:..|.:::|:.|.|...:.:
Zfish   993 PPSGRLCFSNRIQEGKMSMVECVFMNGLNR-TVVWRNSVRPTSLILTDEGNRVYWADTGLAVIAS 1056

  Fly  1110 MNFDGSGRQVILNGLGHPFGLDVNEGRVFWTDWD-TKSVMSAN-KLTGKDTNVIIANSTDLMDIR 1172
            :..||||.:.|....|......||:..|:.|..| ||...|.: :.:||   :.....|::::::
Zfish  1057 VGTDGSGYKEIKTEEGLMAFTLVNKVLVWITKKDSTKCWFSEDEQRSGK---LWFEVDTEIVNLK 1118

  Fly  1173 VFHRTRRRIFNACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIR 1237
            .|.::|::..|.|...||||:.|||..|...||.|.      .|.....:|..:  |.:|..:..
Zfish  1119 AFTKSRQKGTNLCSNGNGGCNQLCLAFPGGKTCRCA------HDHRLLDDGDCR--LESHCPENS 1175

  Fly  1238 QISLDFDHLIDVVLPLPPISNAVA 1261
            :..|.    .|:.|||....|.||
Zfish  1176 KPCLS----EDMCLPLEQFCNGVA 1195

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 16/34 (47%)
LDLa 306..340 CDD:238060 12/33 (36%)
LDLa 347..390 CDD:238060 18/42 (43%)
LDLa 397..431 CDD:238060 12/33 (36%)
LDLa 442..476 CDD:238060 15/34 (44%)
LDLa 480..521 CDD:238060 11/40 (28%)
FXa_inhibition 576..604 CDD:464251 16/27 (59%)
LY 634..671 CDD:214531 8/41 (20%)
LY 680..714 CDD:214531 10/33 (30%)
LY 718..760 CDD:214531 17/41 (41%)
Ldl_recept_b 740..777 CDD:459654 18/36 (50%)
LY 761..803 CDD:214531 16/41 (39%)
LY 806..838 CDD:214531 9/31 (29%)
FXa_inhibition 882..912 CDD:464251 13/30 (43%)
LY 946..985 CDD:214531 7/48 (15%)
NHL <967..1142 CDD:302697 44/188 (23%)
LY 988..1030 CDD:214531 11/52 (21%)
NHL repeat 998..1037 CDD:271333 11/38 (29%)
NHL repeat 1038..1080 CDD:271333 11/44 (25%)
NHL repeat 1084..1119 CDD:271333 10/34 (29%)
FXa_inhibition 1185..1220 CDD:464251 13/34 (38%)
NHL 1260..>1445 CDD:302697 2/2 (100%)
NHL repeat 1260..1296 CDD:271320 2/2 (100%)
LY 1292..1334 CDD:214531
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
lrp13XP_068074315.1 LDLa 36..71 CDD:238060
LDLa 75..110 CDD:238060
LDLa 119..149 CDD:238060 1/5 (20%)
LDLa 196..224 CDD:238060 11/27 (41%)
LDLa 228..263 CDD:238060 16/34 (47%)
LDLa 272..302 CDD:238060 12/29 (41%)
LDLa 307..341 CDD:238060 18/42 (43%)
LDLa 352..381 CDD:238060 10/28 (36%)
LDLa 388..423 CDD:238060 15/34 (44%)
LDLa 428..459 CDD:197566 9/37 (24%)
FXa_inhibition 508..543 CDD:464251 18/36 (50%)
LY <623..649 CDD:214531 9/25 (36%)
Ldl_recept_b 681..719 CDD:459654 18/37 (49%)
LY 703..745 CDD:214531 16/41 (39%)
FXa_inhibition 1131..1163 CDD:464251 13/37 (35%)
LDLa 1171..1203 CDD:197566 8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

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