DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and lrp10

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_688859.4 Gene:lrp10 / 560361 ZFINID:ZDB-GENE-140418-2 Length:748 Species:Danio rerio


Alignment Length:332 Identity:67/332 - (20%)
Similarity:99/332 - (29%) Gaps:134/332 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   267 CTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEH----FTCND------------ 315
            |...:|||.:..|:|.:|.|:|..:|....||...:...|....    .:.||            
Zfish   142 CFPGEFECYSERCLPASWRCNGRVECLGVGDELGSDEDGCYSPEPPIDNSLNDLPPFETTTSTIS 206

  Fly   316 ------------------------GY-------------------CI-------SLAFRCD---- 326
                                    ||                   |:       |...:.:    
Zfish   207 LLSTDAPPPKIPDFPLLPQGGPCGGYLKAFYGSFTPPVPTGQKMECVWTVDPQDSRPLKLELQQL 271

  Fly   327 --GEHDCNDNSDE-------LKCAAVINSCPEGEFKCRGGLGG---------------------- 360
              |..|....:|:       :|....:::....|.:.|.||..                      
Zfish   272 DLGVKDLITITDQPYGMGNIIKTITFVSNNKAVEVESRTGLLSLIYRREPVLEGRGFNATYRITD 336

  Fly   361 --------AGGPSGQCILNRFRCDGDNDCGDWS-DEENCPQKPSLCTSNEYKCADG--------- 407
                    .||..|.|.....||||..||.:.. |||.|..    |.:..:.||.|         
Zfish   337 YCLPWEELCGGSLGGCYTADQRCDGHWDCPETGLDEEACWG----CKAGSFLCAMGGIKKAGHQT 397

  Fly   408 ---TCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAA 469
               .|.....:|:.:.:|..|.||.:|        ..|....|.|::.||:.::|.|||..||..
Zfish   398 ENPVCYSFHERCNYQLNCPDGTDEREC--------TICQPGTFHCDSDRCVFESWRCDGQVDCKD 454

  Fly   470 GEDEVEC 476
            |.||:.|
Zfish   455 GTDELNC 461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 12/33 (36%)
LDLa 306..340 CDD:238060 10/112 (9%)
LDLa 347..390 CDD:238060 17/73 (23%)
LDLa 397..431 CDD:238060 10/45 (22%)
LDLa 442..476 CDD:238060 14/33 (42%)
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:291342
LY 634..671 CDD:214531
NHL <656..793 CDD:302697
LY 680..714 CDD:214531
NHL repeat 681..722 CDD:271320
NHL repeat 726..760 CDD:271320
LY 761..803 CDD:214531
NHL repeat 769..793 CDD:271320
FXa_inhibition 882..912 CDD:291342
LY 946..985 CDD:214531
NHL <967..1142 CDD:302697
LY 988..1030 CDD:214531
NHL repeat 998..1037 CDD:271320
NHL repeat 1038..1080 CDD:271320
NHL repeat 1084..1119 CDD:271320
FXa_inhibition 1185..1220 CDD:291342
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:291342
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
lrp10XP_688859.4 CUB 36..136 CDD:238001
LDLa 142..181 CDD:238060 12/38 (32%)
CUB 229..334 CDD:294042 12/104 (12%)
LDLa 427..461 CDD:238060 14/33 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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