DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp1bb

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_021334671.1 Gene:lrp1bb / 559293 ZFINID:ZDB-GENE-070912-401 Length:4600 Species:Danio rerio


Alignment Length:2056 Identity:626/2056 - (30%)
Similarity:974/2056 - (47%) Gaps:338/2056 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KTAVKRNAPH---YGIHPTNALGRW-DWNKHKQLHSDARIGHLEAGNESREDQLSEELSKF---- 82
            ||.::.:..|   ..:.|.|:...| ||                     .||::::.:.:.    
Zfish   605 KTLLEGDMSHPRAIVVDPLNSWMYWTDW---------------------EEDEVNDSIGRIEKAW 648

  Fly    83 ----GEKLFPVSN--YP----------------PYQQNNEDSQEVHHSGEGRLHTMES-SVPSKT 124
                ..|:|..||  :|                .|..:.|   :::.:|.||:..... .:....
Zfish   649 MDGSNRKIFVTSNMLWPNGLTLDHGTSTMYWCDAYYDHIE---KIYLNGTGRMVVYSGRELNHPF 710

  Fly   125 RISGGTNSNDTPKFRNIG-------------AQRGRTEIAGIRETDRISSRGRDGFIGGPSNKQK 176
            .|:...||....::.|..             .:..|..:.|:|..|..|..|           ..
Zfish   711 GIAQYQNSIFWTEYMNASIFQLDLLSAEVSLLRSERPPLFGLRVYDAQSQLG-----------DN 764

  Fly   177 PFRVN--------LAV------------------------LVQDDPSQPGETYSNCQNSN----- 204
            |.|||        |||                        ..|::|.:.......|:|..     
Zfish   765 PCRVNYGGCGTLCLAVPGGRVCACADNQHLDKHNLTCSDSAGQEEPQRCRSDEFQCRNGRCIRVN 829

  Fly   205 ---ESDENCNPEEDAVPNLQRDCEKTGIHV---MCPRTFRCISKYWLCDGDDDCGDYSDETH--C 261
               :.|::|....|..|::   |......:   .||.. |||.|.|||||.|||||..||::  |
Zfish   830 WICDGDDDCLDGSDEEPHI---CSNHSCPIDQFKCPSN-RCIPKRWLCDGADDCGDNEDESNKTC 890

  Fly   262 GARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDE-THCNRTTCTD-EHFTCNDGYCISLAFR 324
            .|:. |...||.|.||.|:|..|.||.::||.|.||| |.|:..||.. ..|:|.:|.|||:.:.
Zfish   891 SAQP-CRAGQFTCGNGRCVPEAWRCDQDDDCGDMSDESTSCSFPTCEALSQFSCANGRCISMKWH 954

  Fly   325 CDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEE- 388
            ||.:.||.|||||..|   ::.|..|::||         .||:||.:.:.|||||||||:|||. 
Zfish   955 CDSDDDCGDNSDEAGC---VHFCANGQYKC---------TSGRCIPDHWACDGDNDCGDFSDENV 1007

  Fly   389 NC----PQKPSL-CTSNEYKC-ADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSD-E 446
            .|    |..|.: |::.|:.| |||||||:||:||.::||:.|.||.:|..:    ...|... :
Zfish  1008 TCAGVAPALPPVECSAEEFHCRADGTCIPERWRCDGDKDCEDGSDETNCKGV----KRMCDPQAK 1068

  Fly   447 FTC-NNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLC--PTKQNLTNLKICVHQKHICDG 508
            ||| .:|:||.|:|:|||..||....||..|      ...:|  ||:....:..||:.|..||||
Zfish  1069 FTCKTSGKCISKSWVCDGDDDCEDRSDEESC------VSSICKPPTQPCANDSSICLPQNKICDG 1127

  Fly   509 HNECPAGEDEAD-CPKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQ-YL 571
            ..:|....||.. |  ||.......|...|....:....|:|..|..:..:...|..:|.|. :|
Zfish  1128 RMDCADRSDEGPFC--ERCLQGNGGCSHQCSVIPSKGVVCSCPAGLHLGSDNRTCEAVDYCSAHL 1190

  Fly   572 TSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVAN-RWDIRRVTLSNNRYSAIV 635
            .   |||.|.....:.||||..|:.|..|..||.:.......::.: |.:|||:.|..:.||.:|
Zfish  1191 K---CSQICEQHKTTVKCSCYPGWRLDADGESCHSTDPFEAFVIFSIRHEIRRIDLHKHDYSLLV 1252

  Fly   636 KGLHNAIALDFHHRKGLMFWSDVSTDVI---KMVYMNG-TRVRDVIKWGLESPGGIAVDWIHDLL 696
            .||.|.||||||....|::|:||..|.|   |:....| |.|..||:.||.:|.|:|||||...|
Zfish  1253 PGLRNTIALDFHFSHSLLYWTDVVEDKIYRGKLSETGGVTGVEVVIQHGLATPEGLAVDWIAGNL 1317

  Fly   697 FWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPN-PKIERAYMDGTQR 760
            :|.||...::||:...|.:||.:.:..::.|||:.|.||:.:.||:||... |:||...|.|:.|
Zfish  1318 YWIDSNLDQIEVAKLNGEMRTTLIAGGMEHPRALAVDPGQGILFWTDWDATFPRIEATSMSGSGR 1382

  Fly   761 KVI---ISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTH--LPHPFALTLF 820
            .|:   :..| .|||||.:|....:|.|.||:..||..:..|||...:||..|  |.||||::||
Zfish  1383 HVVYKDMEIG-AWPNGLTLDHQERRIVWTDARSDAIYSALYDGSGVIEILRGHEYLSHPFAVSLF 1446

  Fly   821 EDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCS 885
            ...:|||||.|.|::.|:|.||.....:.:....|.|:..|||:|||:.::.|:.:..  ||.||
Zfish  1447 GGGVYWTDWRTNTLARANKWTGHNVTVIQKTSAQPFDLEIYHPSRQPQASNPCEGNDG--RGPCS 1509

  Fly   886 HLCL--PNKTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVP 948
            ||||  .|:|: .|.||..:.|..:.::|.: ..|.:|..||.:||            .||:..|
Zfish  1510 HLCLIDYNRTA-SCSCPHLMKLSLNNRSCVA-LKKFLLYVRRSEIR------------GVDIDNP 1560

  Fly   949 LDNLKHAV---------ALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALD 1004
            ..|:..|:         .:|:.:..:.|||.||:..||.:|.:||:..|.|:..::.:..|||:|
Zfish  1561 YMNVMTALTVPDIDDVTVVDYDALEERIYWADVKTQTIKRAFINGTGLQTVISGDIQNCRGLAID 1625

  Fly  1005 WITDKLYW--TDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERA 1067
            |::..:||  ::....:|.||..:|.::|.:| ..:.||:.:.|:|.:|.::|:|..   .|..|
Zfish  1626 WLSRNMYWLSSENEETQINVARLDGSLKTSVI-HGIDKPKCLTVHPAKGKIYWTDGN---TINVA 1686

  Fly  1068 NMDGHERVTITSKKLIYPN-----GLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVI---LNGL 1124
            ||||      :::|:::.|     ||:||:...|:|::.....|:...|.||||.:||   ...|
Zfish  1687 NMDG------SNRKVLHQNQKEPVGLSIDFPAGKMYWISSANGTINRCNLDGSGFEVIESMKRDL 1745

  Fly  1125 GHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLN 1189
            .....|.|..|:::|.|.|...:.:..|..|::..|:...::.|:.::|:.|..::..|||...|
Zfish  1746 TKATALAVMGGKLWWADDDLAQLGTVAKRDGRNPVVLRNKTSGLVHMKVYDRDGQKGRNACQLNN 1810

  Fly  1190 GGCSHLCLLNPTS---YTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQISLDFDHLIDVVL 1251
            ||||.|||  |||   .|||||:|..|:.||.:| ||...:::::....||.|:||.:...:.::
Zfish  1811 GGCSQLCL--PTSENTRTCACTIGYNLRNDRLSC-EGLNSFLMYSFHEGIRGIALDPNDHTETLM 1872

  Fly  1252 PLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTIYW 1316
            |:.....||.:|.......:||:|...|.|..:..|....:.|:...:...:|:.||.|...:||
Zfish  1873 PISGTLFAVGVDFHAGNDTVYWTDMGLNRISRAKRDQTWREDIITTGINRVEGIAVDWIAGNLYW 1937

  Fly  1317 ADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRI 1381
            .|.|.:.||:|.|:|..|.|:..:.|:.||.:|:..:.|.||||:||....|.|:.|||:::..:
Zfish  1938 TDHGLNLIEIARLNGLYRSVVISEGLDQPRAIAVHPQRGYLFWTEWGKNPCIGRARLDGSDQVTL 2002

  Fly  1382 VTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDY-TGNQRKLIMSSLH-HPYALALSDDNIYWT 1444
            |::.:.||||:::|.:..|:||.|||...|:..:. ||..|::::|:.: ..:::|:....|||:
Zfish  2003 VSSGIAWPNGITIDYEENRLYWCDARTDKIERINLETGEGREIVLSAANVDLFSVAVFGAYIYWS 2067

  Fly  1445 DWKSKALHMTERRNISAKRDIITNIDG----LMDIKIIYQNQNQSTMKNACGNNNGNCSHLCLRN 1505
            | ::.|.....|...|...|.:|...|    |.|:|:..:.:.:.|  |.|..:||.|..||...
Zfish  2068 D-RAHANGSIRRGFKSDATDAVTMRSGLGVNLKDVKVFNKGREKGT--NPCARSNGGCQQLCFHL 2129

  Fly  1506 PSG-YSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPINGVH----- 1564
            .|| .:|.|..|........  ||.. ..|||.:.|:.:..|.|:  |..|:..|:....     
Zfish  2130 GSGRRTCSCAHGYLAEDGFA--CQRY-GGYLLYSERTILKSIHLS--DESDLNSPLQPFENPDYF 2189

  Fly  1565 -GAVVLDYHYRK-----NLLFFADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGIAVDWIADNLY 1623
             ..:.|.:.||:     |.:||:|::...|:.:|  :....:.::..:|.:..|:|.....|.:|
Zfish  2190 KNVIALAFDYRQESSPHNRIFFSDIHFGNIQMIN--DDWSGRQVIVENVGSVEGLAYHRAWDTIY 2252

  Fly  1624 W-----SDTDRKLIEVSRLDGSCRKRIV---EDNLGDPRSLIVHPKKAYLFWSDWSSP-AKIERS 1679
            |     |...|..::.||.....|:.:|   ||:  .|..|.:...:..:||::|:.. ..|.||
Zfish  2253 WTSSTTSSISRYTVDQSRQGAFGRQAVVTMSEDD--HPHVLALDECQNLMFWTNWNEQRPSIMRS 2315

  Fly  1680 YLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHP-FGLT 1743
            .|.|:|..|||::.:..|.|||||....:|.::|.....|.:.:::|..|..||...|.. |||.
Zfish  2316 TLAGNNMKVIISTDVFTPNGLTIDHKAEKLYFSDGSLGKIERCEYDGSHRHVIVRSGPGTFFGLA 2380

  Fly  1744 LFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQP-------KSVNH- 1800
            :..|.|||:||..::|.|:.|..              .|...:....:..||       |..|: 
Zfish  2381 IHGNYIFWSDWTRRAVLRTNKFT--------------GGETKVLRADIPHQPMGIIAVAKDTNNC 2431

  Fly  1801 ----CAQDNGGCTHLCL---NRNVDYVCACPD---VMD-----PKDVACSIKPKVLVHANLE--N 1848
                |...||||..|||   :..|:  |:|..   ::|     .|..:|:|      |...|  |
Zfish  2432 ELSPCRVQNGGCGDLCLLTPDGTVN--CSCRGERVLLDDNRCVSKTSSCNI------HTEFECGN 2488

  Fly  1849 DQLLEYSDESTDDSTPPELLGESNDHGDDGHTKKSDQEREF 1889
            .:.::|           :|..:...|..|    |||::.::
Zfish  2489 GECIDY-----------QLTCDGIAHCKD----KSDEKMQY 2514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 18/34 (53%)
LDLa 306..340 CDD:238060 16/34 (47%)
LDLa 347..390 CDD:238060 20/43 (47%)
LDLa 397..431 CDD:238060 19/34 (56%)
LDLa 442..476 CDD:238060 16/35 (46%)
LDLa 480..521 CDD:238060 13/43 (30%)
FXa_inhibition 576..604 CDD:291342 11/27 (41%)
LY 634..671 CDD:214531 18/40 (45%)
NHL <656..793 CDD:302697 56/144 (39%)
LY 680..714 CDD:214531 15/33 (45%)
NHL repeat 681..722 CDD:271320 17/40 (43%)
NHL repeat 726..760 CDD:271320 15/34 (44%)
LY 761..803 CDD:214531 17/44 (39%)
NHL repeat 769..793 CDD:271320 10/23 (43%)
FXa_inhibition 882..912 CDD:291342 13/31 (42%)
LY 946..985 CDD:214531 13/47 (28%)
NHL <967..1142 CDD:302697 59/184 (32%)
LY 988..1030 CDD:214531 13/43 (30%)
NHL repeat 998..1037 CDD:271320 13/40 (33%)
NHL repeat 1038..1080 CDD:271320 13/41 (32%)
NHL repeat 1084..1119 CDD:271320 13/39 (33%)
FXa_inhibition 1185..1220 CDD:291342 21/37 (57%)
NHL 1260..>1445 CDD:302697 61/186 (33%)
NHL repeat 1260..1296 CDD:271320 9/35 (26%)
NHL repeat 1302..1337 CDD:271320 14/34 (41%)
NHL repeat 1345..1383 CDD:271320 15/37 (41%)
FXa_inhibition <1499..1525 CDD:291342 7/26 (27%)
LY 1600..1640 CDD:214531 10/44 (23%)
LY 1643..1686 CDD:214531 13/46 (28%)
LY 1688..1729 CDD:214531 13/40 (33%)
FXa_inhibition 1801..>1825 CDD:291342 11/26 (42%)
lrp1bbXP_021334671.1 LDLa 38..76 CDD:294076
FXa_inhibition 128..156 CDD:317114
LY 238..274 CDD:214531
LY 282..324 CDD:214531
LY 326..367 CDD:214531
FXa_inhibition 452..484 CDD:317114
LY 516..558 CDD:214531
LY 559..598 CDD:214531
LY 605..654 CDD:214531 10/69 (14%)
LY 655..697 CDD:214531 8/44 (18%)
FXa_inhibition 766..801 CDD:317114 6/34 (18%)
LDLa 854..887 CDD:238060 18/33 (55%)
LDLa 895..926 CDD:197566 15/30 (50%)
LDLa 939..970 CDD:238060 15/30 (50%)
LDLa 974..1005 CDD:197566 18/39 (46%)
LDLa 1021..1056 CDD:238060 19/34 (56%)
LDLa 1065..1099 CDD:238060 15/33 (45%)
FXa_inhibition 1144..1180 CDD:317114 5/35 (14%)
FXa_inhibition 1192..1220 CDD:317114 11/27 (41%)
LY 1248..1289 CDD:214531 19/40 (48%)
LY 1295..1337 CDD:214531 18/41 (44%)
LY 1339..1382 CDD:214531 15/42 (36%)
LY <1394..1427 CDD:214531 15/32 (47%)
Ldl_recept_b 1586..1625 CDD:278487 15/38 (39%)
LY 1609..1651 CDD:214531 12/41 (29%)
LY 1653..1693 CDD:214531 15/49 (31%)
LY <1703..1734 CDD:214531 10/30 (33%)
FXa_inhibition 1806..1842 CDD:317114 21/37 (57%)
NHL <1858..1941 CDD:302697 22/82 (27%)
NHL repeat 1879..1916 CDD:271320 9/36 (25%)
LY 1915..1955 CDD:214531 14/39 (36%)
Ldl_recept_b 1976..2016 CDD:278487 17/39 (44%)
LY 2001..2041 CDD:214531 14/39 (36%)
FXa_inhibition 2115..2150 CDD:317114 11/36 (31%)
Ldl_recept_b 2298..2339 CDD:278487 16/40 (40%)
LY 2323..2365 CDD:214531 13/41 (32%)
FXa_inhibition 2436..2470 CDD:317114 12/35 (34%)
LDLa 2482..2511 CDD:238060 9/43 (21%)
LDLa 2520..2554 CDD:238060
LDLa 2559..2593 CDD:238060
LDLa <2613..2642 CDD:294076
LDLa 2650..2684 CDD:238060
LDLa 2688..2719 CDD:238060
LDLa 2728..2761 CDD:197566
LDLa 2772..2804 CDD:197566
LDLa 2813..2846 CDD:238060
LDLa 2859..2893 CDD:238060
cEGF 2916..2939 CDD:315355
EGF_CA 2936..2969 CDD:214542
LY 3003..3047 CDD:214531
LY 3050..3086 CDD:214531
LY 3135..3174 CDD:214531
FXa_inhibition 3245..3281 CDD:317114
LDLa 3285..3316 CDD:197566
LDLa 3325..3359 CDD:238060
LDLa 3364..3399 CDD:238060
LDLa 3404..3439 CDD:238060
LDLa 3444..3478 CDD:238060
LDLa 3483..3517 CDD:238060
LDLa 3521..3555 CDD:238060
LDLa 3563..3597 CDD:238060
LDLa 3601..3636 CDD:238060
LDLa 3643..3675 CDD:238060
LDLa 3730..3765 CDD:238060
Ldl_recept_b 4008..4048 CDD:278487
LY 4032..4073 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.710

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