DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and LRP1B

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_061027.2	Gene:	LRP1B / 53353	HGNCID:	6693	Length:	4599	Species:	Homo sapiens

Alignment Length:	1814	Identity:	595/1814 - (32%)
Similarity:	927/1814 - (51%)	Gaps:	227/1814 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 PGETYSN--------CQNSN--------ESDENC--NPEEDAV-------PNLQRDCEKTGIHVM 232
            |||...:        |:|.:        :.|::|  ..:||:|       |:.|..|:..
Human   837 PGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNN----- 896

  Fly   233 CPRTFRCISKYWLCDGDDDCGDYSDETH--CGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDF 295
                 |||.|.|||||.:|||...||::  |.||| |..|||.|.||.||||.|:||.|:||.|.
Human   897 -----RCIPKRWLCDGANDCGSNEDESNQTCTART-CQVDQFSCGNGRCIPRAWLCDREDDCGDQ 955

  Fly   296 SDE-THCNRTTCTD-EHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGL 358
            :|| ..|...||.. ..|.|..|.|||..:.||.:.||.|.|||:.|   ::||.:.:|:|
Human   956 TDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC---VHSCFDNQFRC---- 1013

  Fly   359 GGAGGPSGQCILNRFRCDGDNDCGDWSDEE--NCPQK----PSLCTSNEYKC-ADGTCIPKRWKC 416
                 .||:||...:.|||||||||:|||.  ||.::    |:.|..||::| .||.|:|..|:|
Human  1014 -----SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRC 1073

  Fly   417 DKEQDCDGGEDENDC-GSLG-SEHPLTCGSDEFTC-NNGRCILKTWLCDGYPDCAAGEDEVECHL 478
            |.|:||:.|.||..| |::. .:|     ..:|:| :.||||.|.|:|||..||....||.:|
Human  1074 DGEKDCEDGSDEKGCNGTIRLCDH-----KTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDC-- 1131

  Fly   479 QCDLGQFLC-PTKQNLTN-LKICVHQKHICDGHNECPAGEDEADCPKERKCS-EPSPCEQLCIET 540
                ..||| |.|....| ..:|:..:.:|:|..:||.|.||.....|  || ....|...|...
Human  1132 ----DSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDE--CSLNNGGCSNHCSVV 1190

  Fly   541 TAGSNECACRLGYVMDKNKVNCTDIDEC-QYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSC 604
            ......|:|..|..::|:...|..:|.| .:|.   |||.|.....:.||||..|:.|..|..||
Human  1191 PGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLK---CSQVCEQHKHTVKCSCYEGWKLDVDGESC 1252

  Fly   605 KALGGAMTLLVAN-RWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVI---KM 665
            .::......::.: |.:|||:.|....||.:|.||.|.||||||..:.|::|:||..|.|   |:
Human  1253 TSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKL 1317

  Fly   666 VYMNG-TRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRA 729
            ....| :.:..|::.||.:|.|:.||||...::|.||...::||:...|:|||.:.:..::.|||
Human  1318 SESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRA 1382

  Fly   730 IVVHPGEALAFWSDWGPN-PKIERAYMDGTQRKVIIS--KGVTWPNGLAIDFPNSKIYWADAKQH 791
            |.:.|...:.||:||..| |:||.|.|.|..||.|..  |...|||||.:|....:|.|.||:..
Human  1383 IALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSD 1447

  Fly   792 AIECSNLDGSDRNKILSTH--LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHF 854
            ||..:..||::..:|:..|  |.||||::|:...:|||||.|.|:|.|:|.||:....:.:....
Human  1448 AIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQ 1512

  Fly   855 PMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPN-KTSRRCGCPIGLSLKEDGKTCKSTADK 918
            |.|:..|||:|||:..:.|..:..  :|.|||:||.| ..|..|.||..:.|..|.|||.. ..|
Human  1513 PFDLQIYHPSRQPQAPNPCAANDG--KGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYE-MKK 1574

  Fly   919 LVLVARRKDIRLRHLRDNQADPNDVDMIVPLDN---------LKHAVALDWCSDTDFIYWTDVER 974
            .:|.|||.:||            .||:..|..|         :.....:|:.:..:.:||||::.
Human  1575 FLLYARRSEIR------------GVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKT 1627

  Fly   975 STINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYW--TDPSTNRIEVATTNGKMRTLLIWEK 1037
            .||.:|.:||:..:.|:..::.|..|||:||::..|||  ::....:|.||..:|.::|.:| ..
Human  1628 QTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HG 1691

  Fly  1038 LYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPN-----GLAIDYEKSKI 1097
            :.||:.:..:|:.|.::|:|..   .|..|||||      ::.|:::.|     ||:|||.::|:
Human  1692 IDKPQCLAAHPVRGKLYWTDGN---TINMANMDG------SNSKILFQNQKEPVGLSIDYVENKL 1747

  Fly  1098 YFVDGGTKTLENMNFDGSGRQVI---LNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTN 1159
            |::..|..|:...|.||...:||   ...|.....|.:.:.:::|.|.:...:.:.:|..|::..
Human  1748 YWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPT 1812

  Fly  1160 VIIANSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCL-LNPTSYTCACTVGVQLKEDRHTCSEG 1223
            ::...::.::.::|:.:..::..|:|...|||||.||| .:.|:.||.||||..|:::|.:| :|
Human  1813 ILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSC-QG 1876

  Fly  1224 PTQYILFAHRIDIRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDG 1288
            ...:::::....||.|.|:....:|.::|:...|.||.:|...:...|||:|...|.|..:..|.
Human  1877 IESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQ 1941

  Fly  1289 LHVQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYE 1353
            ...:.|:.:.|...:|:.||.|...|||.|.|.:.||||.|:||.|:||..:.|:.||.:|:..|
Human  1942 TWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPE 2006

  Fly  1354 AGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDY-T 1417
            .||||||:||....|.::.|||:|:..:|:..:.||||:|:|.:..::||.|||...|:..|. |
Human  2007 KGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLET 2071

  Fly  1418 GNQRKLIMSSLH-HPYALALSDDNIYWTDWKSKALHMTERRNISAKRDIITNIDG----LMDIKI 1477
            |..|::::|..: ..:::|:....|||:| ::.|.....|.:.:...:.||...|    |.::||
Human  2072 GGNREMVLSGSNVDMFSVAVFGAYIYWSD-RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKI 2135

  Fly  1478 IYQNQNQSTMKNACGNNNGNCSHLCL-RNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRS 1541
            ..:.:.:.|  |.|..:||.|..||| |..|..:|.|..|. |.::..|..::  |.|||.:.|:
Human  2136 FNRVREKGT--NVCARDNGGCKQLCLYRGNSRRTCACAHGY-LAEDGVTCLRH--EGYLLYSGRT 2195

  Fly  1542 GIGMISLNSGDFMDVVLPINGVHG--------AVVLDYHYRK---NLLFFADV---NLDVIRRVN 1592
            .:..|.|:  |..::..||.....        |:..||:.|:   |.:|::|.   |:.:|:.
Human  2196 ILKSIHLS--DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKD-- 2256

  Fly  1593 LLNLTESKVIVGTDVLTPNGIAVDWIADNLYW-----SDTDRKLIEVSRLDGSCRKRIV---EDN 1649
              |..:.:||| .:|.:..|:|.....|.|||     |...|..::.:|.....|:.::   ||:
Human  2257 --NWEDRQVIV-ENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDD 2318

  Fly  1650 LGDPRSLIVHPKKAYLFWSDWSSP-AKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWAD 1713
              .|..|.:...:..:||::|:.. ..|.||.|.|.|..|::::.|..|.|||||:...:|.::|
Human  2319 --HPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSD 2381

  Fly  1714 ALEDNIGQVDFNGKRRQTIVPYAPHPF-GLTLFENSIFWTDWYNKSVYRSQ-------KLARSGY 1770
            .....|.:.:::|.:|..||...|..| .|.:::|.|||:||..:::.||.       |:.||..
Human  2382 GSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDI 2446

  Fly  1771 GNPFEVRDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTHLCL---NRNVDYVCAC-PDVMDPKD 1831
              |.:....::.|.|..:..||       .||..||||..|||   |..|:  |:| .|.:..:|
Human  2447 --PHQPMGIIAVANDTNSCELS-------PCALLNGGCHDLCLLTPNGRVN--CSCRGDRILLED 2500

  Fly  1832 VACSIK-PKVLVHANLE--NDQLLEYSDESTDDSTPPELLGESNDHGDDGHTK-KSDQE 1886
            ..|..| .....::..|  |.:.::|  :.|.|..|              |.| |||::
Human  2501 NRCVTKNSSCNAYSEFECGNGECIDY--QLTCDGIP--------------HCKDKSDEK 2543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	20/34 (59%)
		LDLa	306..340	CDD:238060	15/34 (44%)
		LDLa	347..390	CDD:238060	19/44 (43%)
		LDLa	397..431	CDD:238060	17/34 (50%)
		LDLa	442..476	CDD:238060	15/34 (44%)
		LDLa	480..521	CDD:238060	14/42 (33%)
		FXa_inhibition	576..604	CDD:291342	11/27 (41%)
		LY	634..671	CDD:214531	18/40 (45%)
		NHL	<656..793	CDD:302697	54/143 (38%)
		LY	680..714	CDD:214531	13/33 (39%)
		NHL repeat	681..722	CDD:271320	16/40 (40%)
		NHL repeat	726..760	CDD:271320	16/34 (47%)
		LY	761..803	CDD:214531	17/43 (40%)
		NHL repeat	769..793	CDD:271320	10/23 (43%)
		FXa_inhibition	882..912	CDD:291342	14/30 (47%)
		LY	946..985	CDD:214531	11/47 (23%)
		NHL	<967..1142	CDD:302697	56/184 (30%)
		LY	988..1030	CDD:214531	14/43 (33%)
		NHL repeat	998..1037	CDD:271320	14/40 (35%)
		NHL repeat	1038..1080	CDD:271320	12/41 (29%)
		NHL repeat	1084..1119	CDD:271320	13/39 (33%)
		FXa_inhibition	1185..1220	CDD:291342	18/35 (51%)
		NHL	1260..>1445	CDD:302697	70/186 (38%)
		NHL repeat	1260..1296	CDD:271320	10/35 (29%)
		NHL repeat	1302..1337	CDD:271320	17/34 (50%)
		NHL repeat	1345..1383	CDD:271320	17/37 (46%)
		FXa_inhibition	<1499..1525	CDD:291342	9/26 (35%)
		LY	1600..1640	CDD:214531	13/44 (30%)
		LY	1643..1686	CDD:214531	12/46 (26%)
		LY	1688..1729	CDD:214531	12/40 (30%)
		FXa_inhibition	1801..>1825	CDD:291342	13/27 (48%)
LRP1B	NP_061027.2	FXa_inhibition	165..193	CDD:291342
		NHL	282..459	CDD:302697
		NHL repeat	285..321	CDD:271320
		LDL-receptor class B 1	295..337
		LY	319..361	CDD:214531
		NHL repeat	328..367	CDD:271320
		LDL-receptor class B 2	338..381
		NHL repeat	371..406	CDD:271320
		LDL-receptor class B 3	382..425
		NHL repeat	415..445	CDD:271320
		FXa_inhibition	483..516	CDD:291342
		LY	548..590	CDD:214531
		LDL-receptor class B 4	568..610
		LY	591..630	CDD:214531
		LDL-receptor class B 5	611..656
		LY	637..686	CDD:214531
		LDL-receptor class B 6	657..706
		LY	687..729	CDD:214531
		LDL-receptor class B 7	707..750
		FXa_inhibition	798..833	CDD:291342
		LDLa	886..919	CDD:238060	17/42 (40%)
		LDLa	926..958	CDD:197566	19/32 (59%)
		LDLa	1006..1038	CDD:238060	18/40 (45%)
		LDLa	1053..1088	CDD:238060	17/34 (50%)
		LDLa	1097..1131	CDD:238060	16/38 (42%)
		LDLa	1136..1169	CDD:238060	10/32 (31%)
		FXa_inhibition	1176..1212	CDD:291342	8/35 (23%)
		LY	1280..1318	CDD:214531	19/37 (51%)
		LDL-receptor class B 8	1300..1346		16/45 (36%)
		LY	1327..1367	CDD:214531	14/39 (36%)
		LDL-receptor class B 9	1347..1389		14/41 (34%)
		LY	1371..1414	CDD:214531	16/42 (38%)
		LDL-receptor class B 10	1390..1436		21/45 (47%)
		LY	<1426..1458	CDD:214531	14/31 (45%)
		LDL-receptor class B 11	1437..1480		16/42 (38%)
		LDL-receptor class B 12	1481..1522		16/40 (40%)
		LDL-receptor class B 13	1618..1660		16/41 (39%)
		Ldl_recept_b	1618..1657	CDD:278487	14/38 (37%)
		LY	1641..1683	CDD:214531	13/41 (32%)
		LDL-receptor class B 14	1661..1704		12/43 (28%)
		LY	1685..1724	CDD:214531	14/48 (29%)
		LDL-receptor class B 15	1705..1744		16/47 (34%)
		LY	<1735..1766	CDD:214531	12/30 (40%)
		LDL-receptor class B 16	1745..1787		11/41 (27%)
		FXa_inhibition	1838..1874	CDD:291342	18/35 (51%)
		NHL	1913..2138	CDD:302697	79/225 (35%)
		NHL repeat	1913..1952	CDD:271320	10/38 (26%)
		LDL-receptor class B 17	1922..1964		12/41 (29%)
		LY	1947..1987	CDD:214531	18/39 (46%)
		NHL repeat	1957..1994	CDD:271320	19/36 (53%)
		LDL-receptor class B 28	1965..2007		19/41 (46%)
		NHL repeat	1998..2036	CDD:271320	17/37 (46%)
		LDL-receptor class B 19	2008..2051		20/42 (48%)
		Ldl_recept_b	2008..2048	CDD:278487	19/39 (49%)
		LY	2033..2075	CDD:214531	16/41 (39%)
		NHL repeat	2042..2080	CDD:271320	15/37 (41%)
		LDL-receptor class B 20	2052..2095		12/42 (29%)
		NHL repeat	2089..2128	CDD:271320	10/39 (26%)
		FXa_inhibition	2147..2182	CDD:291342	13/35 (37%)
		LDL-receptor class B 21	2239..2280		12/45 (27%)
		LDL-receptor class B 22	2281..2329		12/49 (24%)
		LDL-receptor class B 23	2330..2374		17/43 (40%)
		Ldl_recept_b	2330..2371	CDD:278487	15/40 (38%)
		LY	2355..2397	CDD:214531	12/41 (29%)
LDL-receptor class B 24	2375..2416		10/40 (25%)
LDL-receptor class B 25	2417..2459		12/43 (28%)
LDLa	2514..2543	CDD:238060	11/44 (25%)
LDLa	2552..2586	CDD:238060
LDLa	2591..2625	CDD:238060
LDLa	2682..2716	CDD:238060
LDLa	2720..2753	CDD:238060
LDLa	2760..2793	CDD:197566
LDLa	2844..2877	CDD:197566
LDLa	2891..2925	CDD:238060
cEGF	2948..2971	CDD:289433
EGF_CA	2968..2998	CDD:214542
LY	3035..3079	CDD:214531
LDL-receptor class B 26	3055..3098
LY	3080..3118	CDD:214531
LDL-receptor class B 27	3099..3141
LY	3123..3164	CDD:214531
LDL-receptor class B 28	3142..3185
LY	3167..3206	CDD:214531
LDL-receptor class B 29	3186..3224
LDL-receptor class B 30	3225..3268
FXa_inhibition	3277..3313	CDD:291342
LDLa	3317..3348	CDD:197566
LDLa	3357..3391	CDD:238060
LDLa	3396..3431	CDD:238060
LDLa	3436..3471	CDD:238060
LDLa	3476..3510	CDD:238060
LDLa	3515..3549	CDD:238060
LDLa	3553..3587	CDD:238060
LDLa	3594..3628	CDD:238060
LDLa	3632..3667	CDD:238060
LDLa	3674..3706	CDD:238060
LDLa	3721..3751	CDD:238060
LDLa	3762..3796	CDD:238060
EGF_CA	3844..3878	CDD:214542
LDL-receptor class B 31	3933..3980
LDL-receptor class B 32	3981..4038
LDL-receptor class B 33	4039..4082
Ldl_recept_b	4039..4079	CDD:278487
LY	4063..4102	CDD:214531
LDL-receptor class B 34	4083..4127
Endocytosis signal. /evidence=ECO:0000255	4492..4495
Endocytosis signal. /evidence=ECO:0000255	4559..4562
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710