DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and sorl1

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_005157607.1 Gene:sorl1 / 497306 ZFINID:ZDB-GENE-050208-22 Length:2213 Species:Danio rerio


Alignment Length:840 Identity:218/840 - (25%)
Similarity:303/840 - (36%) Gaps:279/840 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   171 PSNKQK---PFRVNLAVLVQDDPSQPGETYSNCQNSNESDEN-C-NPEEDAVPNLQR-------- 222
            |.|::.   |..|..:||    ||  ||....|.:..:...| | ..|...:||..|        
Zfish  1035 PGNQRHCVCPDGVPTSVL----PS--GERQCQCPSGYQLHNNTCVKTEHTCLPNQHRCANGKCIS 1093

  Fly   223 ---------DCEKTGIHVMCPRT-------FRCISK------YWLCDGDDDCGDYSDETHCGART 265
                     ||........||.|       |||::.      .:.||.:|||||.|||.||.:. 
Zfish  1094 SIWKCDSDNDCGDMSDEQECPTTSCDPSVQFRCVASGSCIPLAFKCDHEDDCGDNSDEEHCESH- 1157

  Fly   266 NCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHC--NRTTCTDEHFTCNDGYCISLAFRCDGE 328
            .|...:|.|..|.||...|.|||:|||:|:|||.:|  ...||....|.|:.|:||...:.|||:
Zfish  1158 KCGPGEFTCARGACIRDAWRCDGDNDCRDWSDEANCTVGHHTCESSSFQCHTGHCIPQRWVCDGD 1222

  Fly   329 HDCNDNSDE-------LKCAAV----------------INSCPEG--------------EFKCR- 355
            .||.|.|||       .||...                :..||.|              ||.|| 
Zfish  1223 DDCQDGSDEDPTQCGRQKCNGFLCSNGTCLPASAHCNGVEDCPGGADEQNCGPLCAHYMEFVCRN 1287

  Fly   356 ------------GGLGGAGG---------------------------PSGQCILNRFRCDGDNDC 381
                        |....|.|                           .:|.|:...::|||.:||
Zfish  1288 RAQCLFQSLVCDGTRHCADGSDEDPIYAGCSTSVEFEKTCDGYNFQCTNGMCVTLEWKCDGMDDC 1352

  Fly   382 GDWSDEENC--PQKPSLCTSN-EYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEH----- 438
            ||:|||.||  |.:...|||. .::|.:|.|:|..||||.|.||....||:.|....:.|     
Zfish  1353 GDYSDEANCASPTEEPGCTSYFRFECKNGRCVPAWWKCDGENDCGDWSDESQCSGGEALHTPAPG 1417

  Fly   439 PLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHL---------------QCDLGQFLCP 488
            |.||..:.|.|.:|.||:.||:||||.||....||..|..               :|...|||| 
Zfish  1418 PATCAPNRFRCGSGACIVDTWVCDGYADCPDSSDEAGCPTVKGSVTSVTTLPPSGRCTKDQFLC- 1481

  Fly   489 TKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKE--------RKCSEPSPCEQLCIETTAGSN 545
                 .....|:.....||||:.|..|.|||:||..        .:|::...| .|..|...|..
Zfish  1482 -----VKPPACISDWKRCDGHSHCLDGSDEANCPTHGPLLCANGTRCADGEAC-LLNSERCDGFI 1540

  Fly   546 ECACRLGYVMDKNKVNCTD---IDECQYLTSPVCSQKCHNTMGSFK-----------CSCETGYI 596
            :|:.|      .::.||||   :.:.|.|      |...|..|:.|           .||.....
Zfish  1541 DCSDR------SDEHNCTDEQQVYKVQNL------QWTANFSGAVKLTWTRPKNMPTSSCSFVIY 1593

  Fly   597 LRP---------DLRSCKALGGAMTLLVANRWDIRRVT--LS----NNRYSAI--VKGLHNAIAL 644
            .||         |..|.|.......|:....::::..|  ||    .|.|..:  .:||.:.   
Zfish  1594 FRPVGVQQWTSIDTNSNKGSAVLTVLMPDTTYNVKVQTQCLSKQHRTNEYLTLRTPEGLPDP--- 1655

  Fly   645 DFHHRKGLMFWSDVSTDVIKMVYMNGT-------------RVRDVIKWGLESPGGIAVDWIHDLL 696
                .:.|....|.:.|        ||             .:|:.|   :|.....:.:|     
Zfish  1656 ----PQSLQLSCDKADD--------GTVLCSWSPPDKTHGHIREYI---VEYSEKDSAEW----- 1700

  Fly   697 FWTDSGTRRVEVSNFQ-----------------GN---LRTVIASYDLDKPRAIVVHPGE---AL 738
            |...|.:...||.|.|                 ||   ::::|....|..|:..:....|   :|
Zfish  1701 FSLSSTSTNAEVKNLQPSSLYRFRVAAVTSRGVGNWTEIKSIIPQKALSPPKVTITSITEDSMSL 1765

  Fly   739 AFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNL 798
            :..:|:....|:   |:      |:||    |     :...:.|..|.......::.|||
Zfish  1766 SISNDYKVKVKL---YI------VVIS----W-----VFDEHVKESWNYTVPETLKVSNL 1807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/33 (52%)
LDLa 306..340 CDD:238060 15/40 (38%)
LDLa 347..390 CDD:238060 22/96 (23%)
LDLa 397..431 CDD:238060 16/34 (47%)
LDLa 442..476 CDD:238060 16/33 (48%)
LDLa 480..521 CDD:238060 15/40 (38%)
FXa_inhibition 576..604 CDD:464251 9/47 (19%)
LY 634..671 CDD:214531 5/38 (13%)
LY 680..714 CDD:214531 8/50 (16%)
LY 718..760 CDD:214531 8/44 (18%)
Ldl_recept_b 740..777 CDD:459654 7/36 (19%)
LY 761..803 CDD:214531 9/38 (24%)
LY 806..838 CDD:214531
FXa_inhibition 882..912 CDD:464251
LY 946..985 CDD:214531
NHL <967..1142 CDD:302697
LY 988..1030 CDD:214531
NHL repeat 998..1037 CDD:271333
NHL repeat 1038..1080 CDD:271333
NHL repeat 1084..1119 CDD:271333
FXa_inhibition 1185..1220 CDD:464251
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
LY 1292..1334 CDD:214531
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
sorl1XP_005157607.1 VPS10 130..754 CDD:214740
LY 781..822 CDD:214531
LY 825..864 CDD:214531
LY 868..912 CDD:214531
LY 916..954 CDD:214531
LDLa 1079..1113 CDD:238060 5/33 (15%)
LDLa 1118..1154 CDD:238060 13/35 (37%)
LDLa 1159..1193 CDD:238060 17/33 (52%)
LDLa 1242..1273 CDD:238060 3/30 (10%)
LDLa 1282..1310 CDD:197566 7/27 (26%)
LDLa 1327..1361 CDD:238060 12/33 (36%)
LDLa 1376..1405 CDD:238060 13/28 (46%)
LDLa 1421..1455 CDD:238060 16/33 (48%)
LDLa 1474..1509 CDD:238060 15/40 (38%)
LDLa 1522..1551 CDD:238060 7/35 (20%)
FN3 1589..2079 CDD:442628 47/260 (18%)
FN3 1653..1743 CDD:238020 17/112 (15%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.